Trends in Pancreatic Cancer Related Mortality: A Retrospective Analysis using CDC WONDER Database (original) (raw)
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Background: There is a paucity of data comparing the rates and time trends of pancreatic cancer in the southern and the total United States (US), as the risk factors for this cancer are disproportionately distributed in these two regions. The aim of this study was to compare the burden of this fatal cancer in these large geographic regions. Methods: Age-adjusted incidence and mortality rates for patients (≥40 years) diagnosed with pancreatic cancer between 2000 and 2008 were calculated using the SEER 17 (southern and total US) data. Joinpoint regression was utilized to test the relationships between time and pancreatic cancer estimates. Relative, cause-specific, and conditional survival rates were also calculated for those diagnosed between 2000 and 2007. Results: For both the study regions, an increase in incidence and mortality rates was observed in the older age groups (≥60 years), males, and blacks. The overall mortality rate in the southern states was slightly higher (26%) compared to the total US states (25%), with similar incidence rates observed in the two regions (27%). The annual percent increase (APC) in incidence rates was significant for all races and females in the southern states, but for all races and both the sexes in the total US. White females and black males in the southern states had higher three and five-year relative survival rates compared to their counterparts in the total US states. Conclusion: Region-specific similarities and differences in incidence, mortality, and survival for pancreatic cancer were observed in the two regions. Particularly for the southern states, white females were at a significantly higher risk for developing this aggressive cancer compared to their male counterparts, and the incidence rate dramatically decreased for Asian/Pacific Islanders compared to other race/ethnic groups. These findings could have implications regarding preventive care services and treatment options for particular subgroups in the south.
The Lancet Gastroenterology & Hepatology
The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 GBD 2017 Pancreatic Cancer Collaborators* Summary Background Worldwide, both the incidence and death rates of pancreatic cancer are increasing. Evaluation of pancreatic cancer burden and its global, regional, and national patterns is crucial to policy making and better resource allocation for controlling pancreatic cancer risk factors, developing early detection methods, and providing faster and more effective treatments.
Global burden of pancreas cancer: regional disparities in incidence, mortality and survival
Journal of Health Inequalities
Introduction: Despite its low incidence, pancreas cancer is one of the most lethal cancers. This study aims to provide a global overview of pancreas cancer as to incidence, mortality and survival, in selected countries of the world. Methods: Incidence was extracted from CI5plus and NORDCAN. Pancreas cancer deaths and populations were extracted from the WHO mortality database. Age-standardised incidence/mortality rates per 100,000 person-year were computed. Recent mean rates for incidence and mortality and annual percent changes (APC) over the last ten years were computed. Age-standardised relative survival was retrieved from the SEER database, Eurocare-5, NORDCAN and SURVCAN. Results: Recently, incidence ranged from 2.0 in Uganda to 12.9 in Slovakia in men and from 1.3 in India to 7.3 in Slovakia in women. Mortality rates ranged from 1.3 in Thailand to 10.7 in Estonia in men and from 1.0 in Thailand to 6.7 in Finland in women. Over the last ten years, incidence increased in 21/26 countries in men (APC:-6.09% in Uganda to 4.51% in India) and in 23 countries in women (APC:-5.50% in Costa Rica to 6.51% in India). Increasing mortality trends were observed in 16/30 countries for men (APC:-2.62% in Northern Ireland to 4.73% in Thailand) and in 22 countries for women (APC:-1.27% in Mexico to 4.80% in Thailand). Five-year survival ranged from 3.0% (Northern Ireland) to 17.2% (Hong Kong). Survival trends increased since the 1970's from less than 5% to nearly 10% in recent years for USA and Northern Europe. Survival by stage indicated better survival for localised cancer with survival reaching 36% in 2010 compared to regional (11%) and distant cancer (3%). Conclusions: Disparities in pancreas cancer incidence and mortality were observed worldwide. Globally, pancreas cancer survival remained low but increases in one-year relative survival and survival of localised cancer are promising.
Journal of Surgical Oncology, 2016
Background and Objectives: Pancreatic Cancer (PC) is a lethal malignancy that accounts for about 4% of cancer-related deaths worldwide. The aim of this study is to describe the influence of geography (based on WHO regions), socioeconomic development (based on Human Development Index [HDI]) and demographic shift on the temporal trends in global incidence and mortality of PC. Methods: Data (2012-2030) relating to the incidence, mortality of PC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012. Linear regression was used to evaluate trends in total incidence and mortality. Results: We noted a definite association between PC and higher socioeconomic status. Advanced age (age !65) contributed to the rising burden in all socioeconomic regions of the world except in the Low Human Development (LHD) countries where the disease predominantly affected population <65 years of age. Conclusions: The global burden of PC is expected to rise significantly over the next few decades regardless of geographic location, socioeconomic development, age and gender. Advance knowledge of this data can help formulate strategies to specifically target countries and populations that promote public health policy to tackle this lethal disease on the global stage.
Risk Factors for Pancreatic Cancer Mortality: Extended Follow-up of the Original Whitehall Study
Cancer Epidemiology Biomarkers & Prevention, 2009
Given the well-established links between diabetes and elevated rates of pancreatic cancer, there are reasons to anticipate that other markers of metabolic abnormality (raised body mass index, plasma cholesterol, and blood pressure) and their correlates (physical activity and socio-economic status) may also confer increased risk of pancreatic cancer. However, to date, the results of a series of population-based cohort studies are inconclusive. We examined these associations in the original Whitehall cohort study of 17,898 men. A maximum of thirty-eight years of follow-up gave rise to 163 deaths due to carcinoma of the pancreas. While Poisson regression analyses confirmed established risk factor disease associations for increasing age, smoking and type II diabetes, there was essentially no evidence that body mass index (rate ratio; 95% confidence interval per one SD increase: 1.01; 0.86, 1.18), plasma cholesterol (per one SD increase: 0.91; 0.78, 1.07), diastolic blood pressure (per one SD increase: 0.93; 0.78, 1.09), systolic blood pressure (per one SD increase: 0.98; 0.83, 1.15), physical activity (sedentary vs. high: 1.37; 0.89, 2.12), or socio-economic status (clerical[low] vs. professional/executive: 0.95; 0.59, 1.51) offered any predictive value for pancreatic cancer mortality. These results were unchanged following control for a range of covariates.