Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization (original) (raw)

Human platelet phospholipase A2 activity is responsive in vitro to pH and Ca2+ variations which parallel those occurring after platelet activation in vivo

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Human group II 14 kDa phospholipase A2 activates human platelets

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Degradation of phosphatidylinositol-4,5-bisphosphate is insensitive to Ca2+ mobilization in stimulated platelets

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Organization and role of platelet membrane phospholipids as studied with phospholipases A2 from various venoms and phospholipases C from bacterial origin

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1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets

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The Relationship between Phospholipases A 2 and C in Signal Transduction

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Secretory phospholipase A2 is not required for arachidonic acid liberation during platelet activation

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Different susceptibilities of platelet phospholipids to various phospholipases and modifications induced by thrombin. Possible evidence of rearrangement of lipid domains

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Estimation of the phospholipid distribution in the human platelet plasma membrane based on the effect of phospholipase A2 from Naja nigricollis

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No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation

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Human platelet activation by bacterial phospholipase C: Mechanism of inhibition by flurazepam

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Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2

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Investigation of the Relocation of Cytosolic Phospholipase A2 and Annexin V in Activated Platelets

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Phosphorylation of the 47 KDa protein in gamma-thrombin-stimulated human platelets does not activate phospholipase A2: Evidence against lipocortin

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Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

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Carrageenan-induced activation of human platelets is dependent on the phospholipase C Pathway

Jacques Randon

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Studies on enzymes related to diacylglycerol production in activated plateletsI. phosphatidylinositol-specific phospholipasec: Further characterization using a simple method for determination of activity

Gerard Mauco

Biochimica Et Biophysica Acta Lipids and Lipid Metabolism, 1984

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Identification of the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated Human Platelets and HeLa Cells

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Evidence that cytosolic phospholipase A2 is down-regulated by protein kinase C in intact human platelets stimulated with fluoroaluminate

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Effect of ethanol on platelet phospholipase A2

Christopher Stubbs

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Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma

Carla Cicala

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Regulation of Plasma Membrane Ca2+-ATPase by Small GTPases and Phosphoinositides in Human Platelets

Juan Rosado

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Targeting of Porcine Pancreatic Phospholipase A2 to Human Platelets. Introduction of an RGD Sequence and Acyl-Group by Chemical Modification

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A Critical Role for Phospholipase C 2 in IIb 3-mediated Platelet Spreading

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Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C

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Phospholipid-platelet activating factor interactions probed by monolayers, pyrene fluorescence and phospholipase A2

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The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity

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A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

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Correlation between changes in Na+/H+-exchange and cytoplasmic Ca concentration during platelet activation

deependra soni

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A role for protein phosphorylation in modulating Ca2+ elevation in rabbit platelets treated with thapsigargin

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