The Relationship between Phospholipases A 2 and C in Signal Transduction (original) (raw)
Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor. Epinephrine does not induce phospholipase C activation or platelet shape change
W. Siess
The Journal of biological chemistry, 1984
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Secretory phospholipase A2 is not required for arachidonic acid liberation during platelet activation
Bernardo Vargaftig
European Journal of Biochemistry, 1993
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Phosphorylation of the 47 KDa protein in gamma-thrombin-stimulated human platelets does not activate phospholipase A2: Evidence against lipocortin
Eduardo Lapetina
Biochemical and Biophysical Research Communications, 1986
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Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation
W. Siess
The Journal of biological chemistry, 1983
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Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets
Jack Vanderhoek
Journal of Biological Chemistry, 1980
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1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets
Eduardo Lapetina
Biochemical and Biophysical Research Communications, 1984
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Human platelet phospholipase A2 activity is responsive in vitro to pH and Ca2+ variations which parallel those occurring after platelet activation in vivo
Lee Limbird
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1988
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Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2
Bernardo Vargaftig
Biochimica et biophysica acta, 1994
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No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation
Eduardo Lapetina
Biochemical and Biophysical Research Communications, 1988
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Hypersensitivity of phospholipase C in platelets of spontaneously hypertensive rats
Adnane Remmal
Hypertension, 1987
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Studies on topological distribution of arachidonic acid replacement in platelet phospholipids and on enzymes involved in the phospholipid effect accompanying platelet activation
Gerard Mauco
Agents and Actions, 1981
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Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization
Md Motasim Billah
Journal of Biological Chemistry, 1980
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Diacylglycerol lipase pathway is a minor source of released arachidonic acid in thrombin-stimulated human platelets
Bruce Holub
Biochemical and Biophysical Research Communications, 1986
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Studies on enzymes related to diacylglycerol production in activated plateletsI. phosphatidylinositol-specific phospholipasec: Further characterization using a simple method for determination of activity
Gerard Mauco
Biochimica Et Biophysica Acta Lipids and Lipid Metabolism, 1984
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Effect of ethanol on platelet phospholipase A2
Christopher Stubbs
Lipids, 1992
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Organization and role of platelet membrane phospholipids as studied with phospholipases A2 from various venoms and phospholipases C from bacterial origin
Gerard Mauco
Toxicon, 1982
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Human group II 14 kDa phospholipase A2 activates human platelets
Kenneth Clemetson
Biochemical Journal, 1997
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Evidence that cytosolic phospholipase A2 is down-regulated by protein kinase C in intact human platelets stimulated with fluoroaluminate
Vincenza Nardicchi
FEBS Letters, 1999
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Different susceptibilities of platelet phospholipids to various phospholipases and modifications induced by thrombin. Possible evidence of rearrangement of lipid domains
W. Tsai
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1987
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Signaling Responses to Alkyllysophosphatidic Acid: The Activation of Phospholipases A 2and C and Protein Tyrosine Phosphorylation in Human Platelets
Stanislav Svetlov
Arch Biochem Biophys, 1996
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Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-beta and GTP-binding protein Gq
Barbara Sahagan
The Biochemical journal, 1993
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Inhibition of NA+/H+ exchange blocks epinephrine and ADP-induced stimulation of human platelet phospholipase C by a blockade of arachidonic acid release at a prior step
Lee Limbird
Journal of Biological Chemistry
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Asymmetry of arachidonic acid metabolism in the phospholipids of the human platelet membrane as studied with purified phospholipases
Bertrand Perret
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1982
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Arachidonic acid metabolism in platelets and endothelial cells
Babette Weksler
Progress in Lipid Research, 1981
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Role of arachidonic acid metabolism in human platelet activation and irreversible aggregation
Gundu Rao
American Journal of Hematology, 1985
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Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets A determination using purified phospholipases and a rapid method for membrane isolation
Bertrand Perret
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1979
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A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen
W. Siess
The Journal of biological chemistry, 1983
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Aggregation and/or oxygenated products of arachidonic acid are not required for collagen-induced deacylation of phosphatidylcholine in human platelets
L. A . PicheĢ
The Biochemical journal, 1989
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A radioenzymatic assay to identify three groups of phospholipase A2 in platelets
Leda Talib
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2012
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Rapid and transient thrombin stimulation of phosphatidylinositol 4,5-bisphosphate synthesis but not of phosphatidylinositol 3,4-bisphosphate independent of phospholipase C activation in platelets
Gerard Mauco
FEBS Letters, 1993
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Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor
Gavin E Jarvis
FEBS Letters, 2004
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Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets
Eduardo Lapetina
Biochimica et biophysica acta, 1983
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Inhibition of phosphatidic acid production and lysophospholipid formation in collagen-stimulated human platelets by staurosporine, a protein kinase inhibitor
Bruce Holub
Cellular Signalling, 1991
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Phospholipid-platelet activating factor interactions probed by monolayers, pyrene fluorescence and phospholipase A2
Paavo Kinnunen
Chemistry and Physics of Lipids, 1990
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Investigation of the Relocation of Cytosolic Phospholipase A2 and Annexin V in Activated Platelets
Patrick Trotter
Thrombosis Research, 2000
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