ABO blood group alleles and the risk of pancreatic cancer in a Japanese population (original) (raw)
Related papers
Cancer Research, 2010
A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk. C a n c e r I ns t i t u t e , N e w Yo r k , N e w Y o r k;
ABO blood type and the risk of cancer – Findings from the Shanghai Cohort Study
PLOS ONE
ABO blood type is an inherited characteristic. The associations between ABO blood type and risk of all cancer and specific cancers were examined in a prospective cohort study of 18,244 Chinese men enrolled in 1986. During the 25 years of follow-up, 3,973 men developed cancer including 964 lung cancers, 624 colorectal cancers, 560 gastric cancers, 353 liver cancers, and 172 urinary bladder cancers. Hazard ratios (HR) for all cancer and specific cancers by ABO blood type were calculated using Cox proportional hazards models. Compared with blood type A, blood type B was associated with statistically significant reduced risk of all cancers (HR, 0.91, 95% CI:0.84, 0.99). Both blood types B and AB were associated with significantly lower risk of gastrointestinal cancer and colorectal cancer, respectively. Blood type B was also associated with significantly lower risk of stomach cancer and bladder cancer, while blood type AB was associated with significantly increased risk of liver cancer. By histological type, blood types B and AB were associated with lower risk of epidermoid carcinoma and adenocarcinoma, but were not associated with risk of sarcoma, lymphoma, leukemia or other cell types of cancer. The findings of this study support a role of genetic traits related to ABO blood type in the development of cancers in the gastrointestinal and urinary tracts.
ABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis
American Journal of Epidemiology, 2013
Studies over 5 decades have examined ABO blood groups and risk of pancreatic cancer in Western, Asian, and other populations, though no systematic review has been published. We studied data from 908 pancreatic cancer cases and 1,067 population controls collected during December 2006-January 2011 in urban Shanghai, China, and reviewed the literature for all studies of this association. Random-effects meta-analysis provided summary odds ratio estimates according to blood group and by populations endemic versus nonendemic for cytotoxinassociated gene A (CagA)-positive Helicobacter pylori. In our Shanghai study, versus group O, only ABO group A was associated with risk (odds ratio (OR) = 1.60, 95% confidence interval (CI): 1.27, 2.03). In 24 pooled studies, group A showed increased risk in both CagA-nonendemic and-endemic populations (OR pooled = 1.40, 95% CI: 1.32, 1.49). In nonendemic populations, groups B and AB were also associated with higher risk (
Association between the ABO blood group and risk of common cancers
Journal of Evidence-Based Medicine, 2014
ABO blood group, except its direct clinical implications for transfusion and organ transplantation, is generally accepted as an effect factor for coronary heart disease, but the associations between ABO blood group and congenital heart disease (CHD) are not coherent by previous reports. In this study, we evaluated the the potential relationship between ABO blood group and CHD risk. In 39,042 consecutive inpatients (19,795 CHD VS 19,247 controls), we used multivariable logistic regression to evaluate the roles of ABO blood group, gender, and RH for CHD. The associations between ABO blood group and CHD subgroups, were further evaluated using stratification analysis, adjusted by gender. A blood group demonstrated decreased risk for isolated CHD (OR 0.82; 95% CI, 0.78-0.87) in individuals with A blood group in the overall cohort analysis, and the finding was consistently replicated in independent subgroup analysis. ABO blood group may have a role for CHD, and this novel finding provides ABO blood group as a possible marker for CHD, but more studies need to be done. The human histo-blood group ABO system is crucial for clinical transfusion and transplantation medicine. ABO blood group consists of four types: A, B, AB, and O, determined by three alleles at ABO genetic locus 1. A and B alleles encode A and B transferases, respectively, which transfer an N-acetylgalactosamine (GalNAc) or a galactose (Gal) to H substances. O allele encodes a truncated protein deprived of glycosyltransferase activity, which is triggered by a single nucleotide deletion (Δ 261) in exon 6 2. Glycosylation is one of the most common post-translational modifications mediated by enzymes, and it plays important roles in cellular communication during cell differentiation and development. Except the direct clinical implications for transfusion and organ transplantation compatibility, it is being increasingly recognized that ABO blood group allele is associated with risk of venous thromboembolic events, myocardial infarction, cerebrovascular ischemic events and coronary heart disease 3 , individuals with non-O blood groups being at a elevated risk compared to O blood group. Congenital heart disease (CHD) defines a series of structural and functional defects of heart and great vessels arising during embryogenesis. CHD is the most common type of congenital disorder in newborns and accounts for one third of congenital anomalies 4. International Classification of Disease codes 5 , ICD-10 lists the currently identified congenital heart defect subgroups, which designates specific anatomic or hemodynamic lesions. CHD is often partitioned into isolated CHD and syndromic CHD. Isolated CHD occurs as an isolated defect (single or complex defect confined to the cardiovascular system), while syndromic CHD is characterized by heart defect combined with multiple malformations of other organ systems (e.g. neurodevelopmental, genitourinary, or immune system). Down syndrome is the most common developmental syndrome with prominent CHD phenotypes by chromosomal anomaly 6 , and about 40-50% of Down syndrome patients have a heart defect, such as complete atrioventricular canal defect (CAVC). Recent studies have elucidated that isolated CHD and syndromic CHD are triggered by different genetic and epigenetic mechanisms, respectively 6. Thus, these two groups should not be compressed into one for analysis. In 1969, Brendemoen first reported an excess of A blood group among Norway ventricular septal defect patients 7 , however, available reports failed to provide a coherent picture of the association between ABO blood group and CHD risk 8,9. In order to clarify these issues, we utilized a large cohort consisting of 39,042 subjects to investigate the potential relationships between ABO blood group and CHD risk.
ABO Blood Groups and Risk of Cancer: a Systematic Review and Meta-analysis
Asian Pacific Journal of Cancer Prevention, 2014
Background: For decades, studies have been performed to evaluate the association between ABO blood groups and risk of cancer. However, whether ABO blood groups are associated with overall cancer risk remains unclear. We therefore conducted a meta-analysis of observational studies to assess this association. Materials and Methods: A search of Pubmed, Embase, ScienceDirect, Wiley, and Web of Knowledge databases (to May 2013) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews. We included case-control studies and cohort studies with more than 100 cancer cases. Results: The search yielded 89 eligible studies that reported 100,554 cases at 30 cancer sites. For overall cancer risk, the pooled OR was 1.12 (95%CI: 1.09-1.16) for A vs. non-A groups, and 0.84 (95%CI: 0.80-0.88) for O vs. non-O groups. For individual cancer sites, blood group A was found to confer increased risk of gastric cancer (OR=1.
2013
Background Although previous studies have demonstrated an association between ABO blood group and the risk of gastric cancer (GC), only one study has identified these associations using the ABO genotype; however, that study did not evaluate sex differences in this association. The aim of the present study was to investigate whether there are sex-specific differences in the ABO genotypeassociated risk of GC. In addition, we explored the association of the ABO genotype and the clinicopathologic characteristics of GC in a Korean population. Methods We conducted a large-scale case-control study of 3245 GC patients (2204 males, 1041 females) and 1700 controls (821 males, 879 females). The ABO genotype was determined by multicolor real-time polymerase chain reaction (PCR) using displacing probes. Results As compared with genotype OO, genotypes AA and AO in females, but not in males, were associated with a significantly increased risk of GC (odds ratio [OR] 1.56 and 95 % confidence interval [CI] 1.08-2.26 for AA; OR 1.57 and 95 % CI 1.21-2.03 for AO). In a subgroup analysis, blood group A had a significantly increased risk of diffuse-type GC (OR 2.00, 95 % CI 1.43-2.78), but not of intestinal-type (OR 1.31, 95 % CI 0.96-1.79) or mixedtype GC (OR 1.43, 95 % CI 0.92-2.24). Conclusion The ABO genotypes AA and AO were significantly associated with GC only in females and only for diffuse-type GC. These data suggest that the association between ABO blood group and GC risk may differ according to sex and histological type.
Re: ABO Blood Group and the Risk of Pancreatic Cancer
JNCI Journal of the National Cancer Institute, 2010
Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States ( 1 ). Obesity, tobacco use, and family history are well-established risk factors for the development of pancreatic cancer ( 2 , 3 ). Previous studies have also suggested a link between ABO blood group and risk of pancreatic cancer ( 4 , 5 ). More recently, the association of ABO blood type with pancreatic cancer risk was illuminated by a prospective study by Wolpin et al. in the Journal , which demonstrated that people in non -O blood groups were at increased risk of developing pancreatic cancer (adjusted hazard ratio = 1.44; 95% confidence interval [CI] = 1.14 to 1.82). This epidemiological observation was further supported by a recent genome-wide association study ( 7 ) that identified the association of a particular ABO locus on chromosome 9q34 with susceptibility to pancreatic cancer. Risk factors may also have prognostic significance, as exemplified by a prospective study ( 3 ) that showed that obesity was both a risk factor and a prognostic factor for pancreatic cancer. To date, the impact of ABO blood type on clinical outcome in patients with pancreatic cancer has not been examined. We performed a retrospective analysis to determine the prognostic significance of ABO by guest on July 10, 2016 http://jnci.oxfordjournals.org/ Downloaded from by guest on July 10, 2016 http://jnci.oxfordjournals.org/ Downloaded from jnci.oxfordjournals.org JNCI | Correspondence 137 associated with susceptibility to pancreatic cancer . Nat Genet. 2009 ; 41 ( 9 ): 986 -990 .
ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region
Asian Pacific journal of cancer prevention : APJCP, 2012
We aimed to investigate the relationship between blood groups and pancreatic cancer in a Turkish population in Western Blacksea region. This is a retrospective study. Zonguldak Karaelmas University outpatient oncology clinic records were screened for the period between 2004 and 2011. The median age of patients were 56 (± 16) and 132 of 633 study population had pancreatic cancer. Pancreatic cancer patients had significantly higher rates of blood group A compared to controls (OR 1.8, 95%CI, p 0.005). Rates of blood group AB was significantly lower than the control group (OR 0.37, 95% CI, p 0.04). The median survival (IR) time in subjects having the blood groups A, B, AB and O were 7.0 (1-28), 7.0 (2-38), 10 (2-36) and 9.0 (2-48) months respectively; the blood group 0 had significantly higher overall survival (OS) compared to the non-0 groups (p 0.04). Pancreatic cancer patients had more common blood group A in our population. Moreover, blood group AB appeared to be a protective factor...
Oncology Reports, 2013
There is strong epidemiologic evidence indicating that common genetic variability could be implicated in pancreatic cancer risk and, to date, various loci have been proposed. In particular, there is increasing evidence of the involvement of ABO gene variability and pancreatic cancer risk. In a large multicentric study of 1,028 pancreatic ductal adenocarcinoma cases and 2,257 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium, we investigated the suggested association with increased risk for carriers of single nucleotide polymorphisms (SNPs) determining the A or B allele in comparison with the O allele, which encodes for a non-functional enzyme. Since glycosyltransferase activity, encoded by ABO, is higher for the A1 variant compared with the A2 variant, we investigated the hypothesis that A1 carriers were at an increased risk of pancreatic cancer. In our analysis, carriers of the A1 were indeed at greater risk of developing the disease. In addition, we investigated the possible influence that genetic variability at the ABO locus may have in pancreatic cancer survival, but we observed no effect in our population.
2020
Introduction: The association between ABO blood group and cancer has been identified in many epidemiological researches. The aim of the current research was to investigate the association between ABO blood group and the risk of several types of cancer in a Greek adult population. Materials and Methods: A total of 459 individuals who suffered from various types of cancer and 918 non-cancer individuals were enrolled. Blood group data obtained from registration on identity patient’s card. The associations between ABO blood group and cancer estimated using a multivariate logistic regression analysis model, whereas a multinomial model was carried out to estimate adjusted odds ratios for each type of cancer separately. Results: The risk of overall cancer in blood groups A and B individuals was significantly higher than that in O and AB groups, (P = 0.001, OR = 1.96, 95%CI = 1.33–2.87, and P ≤ 0.0001, OR = 2.04 95% CI=1.43–2.90, respectively). Compared to blood type O, blood type A was sig...