Association between ABO Blood Group and Various Types of Cancer: A Case–Control Study in Greek Adults (original) (raw)
Related papers
ABO Blood Groups and Risk of Cancer: a Systematic Review and Meta-analysis
Asian Pacific Journal of Cancer Prevention, 2014
Background: For decades, studies have been performed to evaluate the association between ABO blood groups and risk of cancer. However, whether ABO blood groups are associated with overall cancer risk remains unclear. We therefore conducted a meta-analysis of observational studies to assess this association. Materials and Methods: A search of Pubmed, Embase, ScienceDirect, Wiley, and Web of Knowledge databases (to May 2013) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews. We included case-control studies and cohort studies with more than 100 cancer cases. Results: The search yielded 89 eligible studies that reported 100,554 cases at 30 cancer sites. For overall cancer risk, the pooled OR was 1.12 (95%CI: 1.09-1.16) for A vs. non-A groups, and 0.84 (95%CI: 0.80-0.88) for O vs. non-O groups. For individual cancer sites, blood group A was found to confer increased risk of gastric cancer (OR=1.
Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey
Asian Pacific journal of cancer prevention : APJCP, 2013
The ABO blood groups and Rh factor may affect the risk of lung cancer. We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are nece...
Retrospective Analytical Study of Association Between Abo Blood Group and Malignancy
Journal of Evolution of Medical and Dental Sciences
BACKGROUND The findings of Arid et al in 1953 regarding association between carcinoma of stomach and B blood group and successively in 1954 regarding association between peptic ulcer and O blood group opened a new approach to find association of blood group with other commonly occurring diseases. Blood type antigen system maybe apparently involved in the pathophysiology of wide range of human malignancy by interaction between glycan structures on red blood cells surface and different agents. Therefore, the present study aims to find out to examine the association between ABO blood group and different forms of malignancy, so that a preventive measure can be applied to the risk blood group population. MATERIALS AND METHODS Thirty (30) diagnosed malignant cases as study group and thirty (30) non-malignant cases as control group were selected amongst the surgical patients and ABO blood group were collected and registered. The ABO blood group and Rh factor of both the groups were determined using the tile or slide testing method and the frequency of occurrence of ABO and Rh blood group among malignant and non-malignant population was assessed. The frequency distribution of ABO blood group and Rh factor among the entire malignant population was compared with that of general non-malignant population by Chi-square test. RESULTS The present study indicates that the blood group (B) appears to have higher risk of developing malignancy compared to people of other blood groups, but it is insignificant as per Chi-square test. CONCLUSION The present study suggests that ABO blood group was found to be of non-potential risk factor in the development of malignancy.
ABO blood type and the risk of cancer – Findings from the Shanghai Cohort Study
PLOS ONE
ABO blood type is an inherited characteristic. The associations between ABO blood type and risk of all cancer and specific cancers were examined in a prospective cohort study of 18,244 Chinese men enrolled in 1986. During the 25 years of follow-up, 3,973 men developed cancer including 964 lung cancers, 624 colorectal cancers, 560 gastric cancers, 353 liver cancers, and 172 urinary bladder cancers. Hazard ratios (HR) for all cancer and specific cancers by ABO blood type were calculated using Cox proportional hazards models. Compared with blood type A, blood type B was associated with statistically significant reduced risk of all cancers (HR, 0.91, 95% CI:0.84, 0.99). Both blood types B and AB were associated with significantly lower risk of gastrointestinal cancer and colorectal cancer, respectively. Blood type B was also associated with significantly lower risk of stomach cancer and bladder cancer, while blood type AB was associated with significantly increased risk of liver cancer. By histological type, blood types B and AB were associated with lower risk of epidermoid carcinoma and adenocarcinoma, but were not associated with risk of sarcoma, lymphoma, leukemia or other cell types of cancer. The findings of this study support a role of genetic traits related to ABO blood type in the development of cancers in the gastrointestinal and urinary tracts.
ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region
Asian Pacific journal of cancer prevention : APJCP, 2012
We aimed to investigate the relationship between blood groups and pancreatic cancer in a Turkish population in Western Blacksea region. This is a retrospective study. Zonguldak Karaelmas University outpatient oncology clinic records were screened for the period between 2004 and 2011. The median age of patients were 56 (± 16) and 132 of 633 study population had pancreatic cancer. Pancreatic cancer patients had significantly higher rates of blood group A compared to controls (OR 1.8, 95%CI, p 0.005). Rates of blood group AB was significantly lower than the control group (OR 0.37, 95% CI, p 0.04). The median survival (IR) time in subjects having the blood groups A, B, AB and O were 7.0 (1-28), 7.0 (2-38), 10 (2-36) and 9.0 (2-48) months respectively; the blood group 0 had significantly higher overall survival (OS) compared to the non-0 groups (p 0.04). Pancreatic cancer patients had more common blood group A in our population. Moreover, blood group AB appeared to be a protective factor...
Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study
BMC medicine, 2015
A few studies have shown an association between blood group alleles and vascular disease, including atherosclerosis, which is thought to be due to the higher level of von Willebrand factor in these individuals and the association of blood group locus variants with plasma lipid levels. No large population-based study has explored this association with overall and cause-specific mortality. We aimed to study the association between ABO blood groups and overall and cause-specific mortality in the Golestan Cohort Study. In this cohort, 50,045 people 40- to 70-years old were recruited between 2004 and 2008, and followed annually to capture all incident cancers and deaths due to any cause. We used Cox regression models adjusted for age, sex, smoking, socioeconomic status, ethnicity, place of residence, education and opium use. During a total of 346,708 person-years of follow-up (mean duration 6.9 years), 3,623 cohort participants died. Non-O blood groups were associated with significantly ...
Incidence of Breast Cancer in a Primary Hospital in Relation to ABO Blood Groups System
Journal of Medical and Bioengineering, 2014
The aim of this study was to investigate the association of ABO blood group system with breast cancer in a primary hospital in Penang. Moreover the study was conducted to assess the utility of ABO blood group as a preclinical marker. The study sample consisted of 70 and 140 cancer and controlled subjects respectively. Factors such as blood group, age, ethnic group were examined in 70 female subjects of breast cancer. Blood samples were taken from 140 healthy subjects to examin the distribution of ABO blood group types with different Malaysian races. Incidence in cancer patients is high with blood group A and AB compared with control group; however the association was not statistically significant. For blood group B and O were lower in cancer patients compared to control healthy group and the association was statistically significant. The results also indicated that blood type should be considered along with other risk factors to understand the patient's risk. Conclusion: Blood group A is highly associated with breast cancer (30.0%), in contrast to the other blood groups.
International Journal of Hematology-Oncology and Stem Cell Research
Background: Breast cancer and cervix cancer are the prevalent and deadly types of solid tumors around the world. According to the importance of cancer, it is necessary to understand predisposing factors that affect cancer risk. In this regard, previous studies suggest that blood types particularly ABO and Rh-Hr Blood-Group System could play roles in the risk and different features of cancers. In the present study, we aimed to evaluate the potential of ABO and Rh blood groups as risk factors for breast cancer and cervix cancer. Materials and Methods: A retrospective study included 109 and 14 patients diagnosed with breast cancer and cervix cancer, respectively with known ABO and Rh blood types, between 2018 and 2020 in Khuzestan province, Iran. For compression of ABO blood groups distribution between the cancer patients group and the healthy population, we used data from a large-scale study that report the distribution of ABO blood groups in 29,922 blood donors in Khuzestan province....
Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor
International Seminars in Surgical Oncology, 2009
Aim: To investigate the correlation between breast cancer in Greek women and ABO blood groups. Material-methods: In 166 female patients with breast cancer factors such as blood group, histological type, family history, presence or absence of nodal and/or distant metastases were examined. These patients had similar demographic, clinical, surgical, immunohistochemical, laboratory, and follow-up data and this group is representative of general population of women in Greece. Results: The ductal type of breast cancer was differentially distributed in blood groups Rh (+) (P ≤ 0.001). In patients with A (+) blood group the ductal type of breast cancer was present in 49.6% of cases, in relation to the other blood groups and in AB blood group the same type occurred rarely (3.6%). Rh (+) women with positive family history were more often found in A blood group. The relative risk of metastasis in Rh (-) patients was 4.2 times higher than that in Rh (+) patients. Among Rh (+) patients, the relative risk of metastasis was 1.29 times higher in A blood group than in other blood groups. Conclusion: Blood group A is often associated with ductal breast cancer (49.6%), in contrast to the other blood groups and particularly to blood group AB (3.6%). Blood group A and, particularly, A (-) has the worst prognosis of all.
Association between the ABO blood group and risk of common cancers
Journal of Evidence-Based Medicine, 2014
ABO blood group, except its direct clinical implications for transfusion and organ transplantation, is generally accepted as an effect factor for coronary heart disease, but the associations between ABO blood group and congenital heart disease (CHD) are not coherent by previous reports. In this study, we evaluated the the potential relationship between ABO blood group and CHD risk. In 39,042 consecutive inpatients (19,795 CHD VS 19,247 controls), we used multivariable logistic regression to evaluate the roles of ABO blood group, gender, and RH for CHD. The associations between ABO blood group and CHD subgroups, were further evaluated using stratification analysis, adjusted by gender. A blood group demonstrated decreased risk for isolated CHD (OR 0.82; 95% CI, 0.78-0.87) in individuals with A blood group in the overall cohort analysis, and the finding was consistently replicated in independent subgroup analysis. ABO blood group may have a role for CHD, and this novel finding provides ABO blood group as a possible marker for CHD, but more studies need to be done. The human histo-blood group ABO system is crucial for clinical transfusion and transplantation medicine. ABO blood group consists of four types: A, B, AB, and O, determined by three alleles at ABO genetic locus 1. A and B alleles encode A and B transferases, respectively, which transfer an N-acetylgalactosamine (GalNAc) or a galactose (Gal) to H substances. O allele encodes a truncated protein deprived of glycosyltransferase activity, which is triggered by a single nucleotide deletion (Δ 261) in exon 6 2. Glycosylation is one of the most common post-translational modifications mediated by enzymes, and it plays important roles in cellular communication during cell differentiation and development. Except the direct clinical implications for transfusion and organ transplantation compatibility, it is being increasingly recognized that ABO blood group allele is associated with risk of venous thromboembolic events, myocardial infarction, cerebrovascular ischemic events and coronary heart disease 3 , individuals with non-O blood groups being at a elevated risk compared to O blood group. Congenital heart disease (CHD) defines a series of structural and functional defects of heart and great vessels arising during embryogenesis. CHD is the most common type of congenital disorder in newborns and accounts for one third of congenital anomalies 4. International Classification of Disease codes 5 , ICD-10 lists the currently identified congenital heart defect subgroups, which designates specific anatomic or hemodynamic lesions. CHD is often partitioned into isolated CHD and syndromic CHD. Isolated CHD occurs as an isolated defect (single or complex defect confined to the cardiovascular system), while syndromic CHD is characterized by heart defect combined with multiple malformations of other organ systems (e.g. neurodevelopmental, genitourinary, or immune system). Down syndrome is the most common developmental syndrome with prominent CHD phenotypes by chromosomal anomaly 6 , and about 40-50% of Down syndrome patients have a heart defect, such as complete atrioventricular canal defect (CAVC). Recent studies have elucidated that isolated CHD and syndromic CHD are triggered by different genetic and epigenetic mechanisms, respectively 6. Thus, these two groups should not be compressed into one for analysis. In 1969, Brendemoen first reported an excess of A blood group among Norway ventricular septal defect patients 7 , however, available reports failed to provide a coherent picture of the association between ABO blood group and CHD risk 8,9. In order to clarify these issues, we utilized a large cohort consisting of 39,042 subjects to investigate the potential relationships between ABO blood group and CHD risk.