Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry (original) (raw)

Polyketide synthesis in vitro on a modular polyketide synthase

Jesús Mateo Cortés

Chemistry & Biology, 1995

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Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

Peter Leadlay

Chemistry & Biology, 2001

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Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

Jesús Mateo Cortés

Chemistry & Biology, 1998

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

Frank Schulz

Organic & Biomolecular Chemistry, 2011

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes

Hugo Menzella

Nature Biotechnology, 2005

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Structure of a modular polyketide synthase

David Sherman

Nature, 2014

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Purification and Characterization of Bimodular and Trimodular Derivatives of the Erythromycin Polyketide Synthase †

Rembert Pieper

Biochemistry, 1997

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Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli

Jay D Keasling

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Evidence for Two Catalytically Independent Clusters of Active Sites in a Functional Modular Polyketide Synthase †

Rembert Pieper

Biochemistry, 1996

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

Jesús Mateo Cortés

Molecular Microbiology, 2002

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Engineering polyketide synthases and nonribosomal peptide synthetases

Gavin P Williams

Current Opinion in Structural Biology, 2013

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An artificial pathway for polyketide biosynthesis

Lindsay Nichols

Nature Catalysis, 2020

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New Start and Finish for Complex Polyketide Biosynthesis

Patrick Caffrey

Chemistry & Biology, 2004

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The Assembly Line Enzymology of Polyketide Biosynthesis

Paul Race

Methods in molecular biology (Clifton, N.J.), 2016

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The Structure of Docking Domains in Modular Polyketide Synthases

Peter Leadlay

Chemistry & Biology, 2003

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A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

Eduardo Rodriguez

Biochemistry, 2003

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Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

Peter Leadlay

Chemistry & Biology, 2000

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ASMPKS: an analysis system for modular polyketide synthases

Kiejung Park

BMC Bioinformatics, 2007

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Active-site residue, domain and module swaps in modular polyketide synthases

Peter Leadlay

Journal of Industrial Microbiology and Biotechnology, 2003

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The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

Frank Schulz

Molecules, 2011

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Structural rearrangements of a polyketide synthase module during its catalytic cycle

David Sherman

Nature, 2014

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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

Larry Miercke

Proceedings of the National Academy of Sciences, 2001

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Insights into Modular Polyketide Synthase Loops Aided by Repetitive Sequences

Samantha Spears

2020

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Dissecting complex polyketide biosynthesis

Patrick Caffrey

Computational and structural biotechnology journal, 2012

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Crystal Structure of a Bacterial Type III Polyketide Synthase and Enzymatic Control of Reactive Polyketide Intermediates

Joseph Noel

Journal of Biological Chemistry, 2004

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Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in Phoslactomycin Biosynthesis

Nadaraj Palaniappan

Journal of the American Chemical Society, 2007

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Faculty of 1000 evaluation for Structure of a modular polyketide synthase

Sean Lund

F1000 - Post-publication peer review of the biomedical literature, 2014

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Autonomous folding of interdomain regions of a modular polyketide synthase

Filip Meersman

FEBS Journal, 2007

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Modular organization of genes required for complex polyketide biosynthesis

Michael Staver

Science, 1991

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Technical Advances to Accelerate Modular Type I Polyketide Synthase Engineering towards a Retro-biosynthetic Platform

Yao Wan

Biotechnology and Bioprocess Engineering, 2019

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