Polyketide synthesis in vitro on a modular polyketide synthase (original) (raw)
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
Peter Leadlay
Chemistry & Biology, 2001
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Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
Jay D Keasling
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Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension
Jesús Mateo Cortés
Chemistry & Biology, 1998
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Diversity of Polyketide Synthases Found in the Aspergillus and Streptomyces Genomes
Yi-ming Chiang
Molecular Pharmaceutics, 2008
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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
Hugo Menzella
Nature Biotechnology, 2005
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Purification and Characterization of Bimodular and Trimodular Derivatives of the Erythromycin Polyketide Synthase †
Rembert Pieper
Biochemistry, 1997
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Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
Jesús Aparicio
Science, 1994
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The Assembly Line Enzymology of Polyketide Biosynthesis
Paul Race
Methods in molecular biology (Clifton, N.J.), 2016
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Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic a-lipomycin
Jay D Keasling
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Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
Olga Sekurova
Chemistry & Biology, 2000
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Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase
Jesús Aparicio
Journal of Biological Chemistry, 1994
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New Start and Finish for Complex Polyketide Biosynthesis
Patrick Caffrey
Chemistry & Biology, 2004
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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
Kai Wu
Gene, 2000
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Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry
Peter Leadlay
FEBS Journal, 2005
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An artificial pathway for polyketide biosynthesis
Lindsay Nichols
Nature Catalysis, 2020
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Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
Peter Leadlay
Chemistry & Biology, 2000
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Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline
Juha Hakala
Chemistry & Biology, 1997
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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase
Jesús Mateo Cortés
Molecular Microbiology, 2002
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Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster
Anyarat Thanapipatsiri
ChemBioChem, 2016
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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase
Frank Schulz
Organic & Biomolecular Chemistry, 2011
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Modular organization of genes required for complex polyketide biosynthesis
Michael Staver
Science, 1991
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A Polyketide Synthase in Glycopeptide Biosynthesis
Riham Shawky
Journal of Biological Chemistry, 2001
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Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues
Chris Farnet
Biochemistry, 2014
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Initiation of Polyene Macrolide Biosynthesis: Interplay between Polyketide Synthase Domains and Modules as Revealed via Domain Swapping, Mutagenesis, and Heterologous Complementation
Sondre Heia
Applied and Environmental Microbiology, 2011
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Crystal Structure of a Bacterial Type III Polyketide Synthase and Enzymatic Control of Reactive Polyketide Intermediates
Joseph Noel
Journal of Biological Chemistry, 2004
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The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
Frank Schulz
Molecules, 2011
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Synthetic Polyketide Enzymology: Platform for Biosynthesis of Antimicrobial Polyketides
Jantana Wongsantichon
ACS Catalysis, 2015
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Mechanistic insights into the biosynthesis of polyketide antibiotics
Azmiri Sultana
2006
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Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase
Frank Schulz
ACS Chemical Biology, 2013
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Recombinatorial biosynthesis of polyketides
Antonio Starcevic
Journal of Industrial Microbiology & Biotechnology, 2011
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Type III Polyketide Synthase β-Ketoacyl-ACP Starter Unit and Ethylmalonyl-CoA Extender Unit Selectivity Discovered by Streptomyces coelicolor Genome Mining
Joseph Noel
Journal of the American Chemical Society, 2006
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Iterative Assembly of Two Separate Polyketide Chains by the Same Single-Module Bacterial Polyketide Synthase in the Biosynthesis of HSAF
Haoxin Wang
Angewandte Chemie, 2014
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Type II Thioesterase ScoT, Associated with Streptomyces coelicolor A3(2) Modular Polyketide Synthase Cpk, Hydrolyzes Acyl Residues and Has a Preference for Propionate
Krzysztof J Pawlik
Applied and Environmental Microbiology, 2009
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Disruption of an Aromatase/Cyclase from the Oxytetracycline Gene Cluster of Streptomyces rimosus Results in Production of Novel Polyketides with Shorter Chain Lengths
Arinthip Thamchaipenet
Journal of Biological Chemistry, 1999
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Engineering polyketide synthases and nonribosomal peptide synthetases
Gavin P Williams
Current Opinion in Structural Biology, 2013
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