Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels (original) (raw)
Cocaine binds to a common site on open and inactivated Nav1. 5 sodium channels
Mohamed Chahine
View PDFchevron_right
Molecular and kinetic determinants of local anaesthetic action on sodium channels
Gerald Zamponi
Toxicology Letters, 1998
View PDFchevron_right
Block of Inactivation-deficient Na+ Channels by Local Anesthetics in Stably Transfected Mammalian Cells: Evidence for Drug Binding Along the Activation Pathway
Edward Moczydlowski
The Journal of General Physiology, 2004
View PDFchevron_right
Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation
Akihiko Sunami
Neuroscience Letters, 2003
View PDFchevron_right
Local Anesthetic Anchoring to Cardiac Sodium Channels : Implications Into Tissue-Selective Drug Targeting
David Dime
Circulation Research, 1999
View PDFchevron_right
Comparative Inhibition of Voltage-Gated Cation Channels by Local Anesthetics
Daniel Chernoff
Annals of the New York Academy of Sciences, 1991
View PDFchevron_right
Block of Inactivation-deficient Na+ Channels by Local Anesthetics in Stably Transfected Mammalian Cells
Edward Moczydlowski
The Journal of General Physiology, 2004
View PDFchevron_right
Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding
Pato Velez
Molecular Pharmacology, 2009
View PDFchevron_right
Interaction of local anesthetics with a peptide encompassing the IV/S4–S5 linker of the Na+ channel
Clovis Nakaie
Biophysical Chemistry, 2006
View PDFchevron_right
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics
Frank Starmer
Biophysical Journal, 1984
View PDFchevron_right
An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity
Jeffrey Aronson
British Journal of Pharmacology, 2004
View PDFchevron_right
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics
Akihiko Sunami
Molecular pharmacology, 2001
View PDFchevron_right
Bupivacaine Blocks N-Type Inactivating Kv Channels in the Open State: No Allosteric Effect on Inactivation Kinetics
Fredrik Elinder
Biophysical Journal, 2008
View PDFchevron_right
Pharmacological modulation of human cardiac Na+ channels
robert barchi
European Journal of Pharmacology: Molecular Pharmacology, 1994
View PDFchevron_right
Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics
Sandipan Chowdhury
The Journal of general …, 2010
View PDFchevron_right
Stereoselective Interactions between Local Anesthetics and Ion Channels
Angela Prieto
Chirality, 2012
View PDFchevron_right
What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs
Frank Starmer
Cardiovascular …, 2003
View PDFchevron_right
α 1Acid glycoprotein reverses cocaine-induced sodium channel blockade in cardiac myocytes
Yu-ling Ma
Toxicology, 2006
View PDFchevron_right
Selective Interaction of Local Anesthetics with a Peptide Derived from the Voltage-Gated Na+ Channel
Alberto Spisni, Clovis Nakaie
View PDFchevron_right
Faculty of 1000 evaluation for Sodium channels and the synaptic mechanisms of inhaled anaesthetics
Bruce MacIver
F1000 - Post-publication peer review of the biomedical literature, 2009
View PDFchevron_right
The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels
Vladislav Nesterenko, Frank Starmer
Molecular pharmacology, 1996
View PDFchevron_right
Ketamine blockade of voltage-gated sodium channels: evidence for a shared receptor site with local anesthetics
John Kulli
Anesthesiology, 2001
View PDFchevron_right
Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Nav1.7 and Nav1.5
Jin Sung Choi
Biomolecules & Therapeutics
View PDFchevron_right
Interaction of local anesthetics with the K+channel pore domain
Edward Moczydlowski
Channels, 2013
View PDFchevron_right
Potent and use-dependent block of cardiac sodium channels by U-50,488H, a benzeneacetamide kappa opioid receptor agonist
Michael K Pugsley
Experimental and clinical cardiology, 2001
View PDFchevron_right
Local anesthetic properties of opioids and phencyclidines: Interaction with the voltage-dependent, batrachotoxin binding site in sodium channels
Kenner Rice
Neuropeptides, 1985
View PDFchevron_right
Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
Werner Treptow
Biophysical Journal, 2015
View PDFchevron_right
Differential modulation of Na v 1.7 and Na v 1.8 peripheral nerve sodium channels by the local anesthetic lidocaine
Kausalia Vijayaragavan
British Journal of Pharmacology, 2004
View PDFchevron_right
Sodium channel selectivity filter regulates antiarrhythmic drug binding
Akihiko Sunami
Proceedings of the National Academy of Sciences, 1997
View PDFchevron_right
Voltage-gated sodium channels and their roles in drug action
Amit Kumar
Current Anaesthesia and Critical Care, 2005
View PDFchevron_right
A molecular link between activation and inactivation of sodium channels
Michael O'Leary
The Journal of General Physiology, 1995
View PDFchevron_right