Pentacycloundecane-diol-Based HIV-1 Protease Inhibitors: Biological Screening, 2 D NMR, and Molecular Simulation Studies (original) (raw)
Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study
Bahareh Honarparvar
Journal of Biomedical Science, 2015
View PDFchevron_right
Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P1'-P2' Amide Bond Isostere
Thomas Meek
Journal of Medicinal Chemistry, 1994
View PDFchevron_right
HIV protease inhibitor HOE/BAY 793, structure-activity relationships in a series of C2-symmetric diols
Jochen Knolle
Bioorganic & Medicinal Chemistry, 1995
View PDFchevron_right
Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, x-ray crystallography, and infected T-cell assays
Michael Minnich
Biochemistry, 1992
View PDFchevron_right
Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors
Juraj Sedláček, Hana Petroková, Jiří Brynda
European Journal of Biochemistry, 2004
View PDFchevron_right
New hydroxyethylamine HIV protease inhibitors that suppress viral replication
Vara Prasad
Journal of Medicinal Chemistry, 1992
View PDFchevron_right
New Active HIV-1 Protease Inhibitors Derived from 3-Hexanol: Conformation Study of the Free Inhibitors in Crystalline State and in Complex with the Enzyme
Jindřich Hašek
Chemical Biology & Drug Design, 2012
View PDFchevron_right
Structure Based Design of Inhibitors of Aspartic Protease of HIV-1
Alessandro Tossi
Letters in Drug Design & Discovery, 2005
View PDFchevron_right
Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease …
Yasien Sayed
Bioorganic …, 2011
View PDFchevron_right
Design and synthesis of inhibitors for the HIV-1 protease
Nicholas Camp
1994
View PDFchevron_right
Two-step binding mechanism for HIV protease inhibitors
Thomas Spector
Biochemistry, 1992
View PDFchevron_right
Nonpeptidic Potent HIV-1 Protease Inhibitors: (4-Hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes That Span P1-P2' Subsites in a Unique Mode of Binding
Stephen Rapundalo
Journal of Medicinal Chemistry, 1995
View PDFchevron_right
Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors
Yasien Sayed
Bioorganic Chemistry, 2012
View PDFchevron_right
Small-Sized Human Immunodeficiency Virus Type1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S 2 ′ Pocket
Hamdy Abdel-Rahman
Journal of Medicinal Chemistry, 2009
View PDFchevron_right
HIV-1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure
Roberto Tomatis
The Journal of Peptide Research, 2009
View PDFchevron_right
Cyclic HIV protease inhibitors capable of displacing the active site structural water molecule
Bruce Aungst
Drug Discovery Today, 1997
View PDFchevron_right
Discovery and optimization of nonpeptide HIV-1 protease inhibitors
John Domagala
Bioorganic & Medicinal Chemistry, 1996
View PDFchevron_right
Inhibitors of HIV-1 Protease Containing the Novel and Potent (R)-(Hydroxyethyl)sulfonamide Isostere
Martin Bryant
Journal of Medicinal Chemistry, 1995
View PDFchevron_right
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group
Jennifer Gesell
ACS Medicinal Chemistry Letters, 2016
View PDFchevron_right
Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease
Maya Makatini, Bahareh Honarparvar, Yasien Sayed
Bioorganic & Medicinal Chemistry Letters, 2011
View PDFchevron_right
Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors
Stefano Norbedo
The Journal of Organic Chemistry, 1997
View PDFchevron_right
Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease
Mihály Tóth
Journal of Medicinal Chemistry, 1990
View PDFchevron_right
Configurations of Diastereomeric Hydroxyethylene Isosteres Strongly Affect Biological Activities of a Series of Specific Inhibitors of Human-Immunodeficiency-Virus Proteinase
Juraj Sedláček
European Journal of Biochemistry, 1997
View PDFchevron_right