Design and synthesis of inhibitors for the HIV-1 protease (original) (raw)
Synthesis of peptide analogues containing phosphonamidate methyl ester functionality: HIV-1 proteinase inhibitors possessing unique cell uptake properties
Nicholas Camp
Bioorganic & Medicinal Chemistry, 1995
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GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions
Klára Grantz Šašková, Jiří Brynda
Journal of Virology, 2014
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In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile
carina cannizzaro
Antimicrobial Agents and Chemotherapy, 2011
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Peptides derived from HIV-1 vif: a non-substrate based novel type of HIV-1 protease inhibitors 1 1 Edited by J. Karn
Chaim Gilon
J Mol Biol, 1999
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Peptides derived from HIV-1 vif: a non-substrate based novel type of HIV-1 protease inhibitors
Chaim Gilon
Journal of Molecular Biology, 1999
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An Orally Bioavailable HIV1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis
Sherin S. Abdel-Meguid
Biochemistry, 1994
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Design, Synthesis and Screening of Novel PCU-peptide/peptoid Derived HIV Protease Inhibitors
Maya Makatini
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Substrate-Based Cyclic Peptidomimetics of Phe-Ile-Val That Inhibit HIV-1 Protease Using a Novel Enzyme-Binding Mode
Jakob Begun
Journal of the American Chemical Society, 1996
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Structure–activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P1 site
Shuichi Miyamoto
Bioorganic & Medicinal Chemistry, 1999
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A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs
Donna Ferguson
Journal of Medicinal Chemistry, 1994
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Two-step binding mechanism for HIV protease inhibitors
Thomas Spector
Biochemistry, 1992
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Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis
Michael Minnich
Biochemistry, 1993
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Discovery and optimization of nonpeptide HIV-1 protease inhibitors
John Domagala
Bioorganic & Medicinal Chemistry, 1996
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Structure Based Design of Inhibitors of Aspartic Protease of HIV-1
Alessandro Tossi
Letters in Drug Design & Discovery, 2005
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Small-Molecule Inhibitors of HIV-1 Protease Dimerization Derived from Cross-Linked Interfacial Peptides
Michael Shultz
Angewandte Chemie International Edition, 2000
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Design and synthesis of sulfoximine based inhibitors for HIV1 protease
Abbas Raza
Bioorganic & Medicinal Chemistry Letters, 2008
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Pentacycloundecane-diol-Based HIV-1 Protease Inhibitors: Biological Screening, 2 D NMR, and Molecular Simulation Studies
Bahareh Honarparvar, Yasien Sayed
ChemMedChem, 2012
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Molecular Recognition of Macrocyclic Peptidomimetic Inhibitors by HIV1 Protease † , ‡
David Fairlie
Biochemistry, 1999
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Design of peptidomimetic inhibitors of aspartic protease of HIV-1 containing –PheΨPro– core and displaying favourable ADME-related properties
S. Miertus, Vladimir Frecer
Journal of Molecular Graphics and Modelling, 2008
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Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors
Gert Kruger
Bioorganic Chemistry, 2012
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Design, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance
Md Akbar Ali
Journal of Medicinal Chemistry, 2012
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Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease …
Yasien Sayed
Bioorganic …, 2011
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Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus
Celia Schiffer
Journal of Medicinal Chemistry, 2005
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A new class of HIV-1 protease inhibitor: The crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere
Charles Craik
Bioorganic & Medicinal Chemistry, 1996
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Design of new inhibitors of HIV-1 aspartic protease
Alessandro Tossi
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The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains
Emilio Emini
Bioorganic & Medicinal Chemistry Letters, 2003
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Potency Comparison of Peptidomimetic Inhibitors against HIV-1 and HIV-2 Proteinases: Design of Equipotent Lead Compounds
Milan Souček, Jan Konvalinka, Jan Weber
Archives of Biochemistry and Biophysics, 1997
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Inhibition of HIV-1 Protease by Oxim Derivatives
Yasuko Ishikawa
Biochemical and Biophysical Research Communications, 1997
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Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P1/P1‘ Compounds: Correlation between Lipophilicity and Cytotoxicity
Sk masud Alam
Journal of Medicinal Chemistry, 1996
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Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties
Wes Kazmierski
Bioorganic & Medicinal Chemistry Letters, 2004
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Design, synthesis, and activity of conformationally-constrained macrocyclic peptide-based inhibitors of HIV protease
Roger Smith
Bioorganic & Medicinal Chemistry Letters, 1994
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Phenanthridine derivatives as potential HIV‑1 protease inhibitors
Pavel Ershov
Biomedical Reports, 2020
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Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors
Roger Tung
Bioorganic & Medicinal Chemistry Letters, 1998
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