Relationship between lipid profiles and kidney function in patients with type 1 diabetes (original) (raw)
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Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes
Diabetologia, 2009
Aims/hypothesis We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes. Methods A total of 2,304 adult patients with type 1 diabetes and available lipid profiles participating in the Finnish Diabetic Nephropathy Study (FinnDiane) were evaluated. Data on progression of renal disease were verified from medical files and patients were followed for 5.4±2.0 (mean ± SD) years. Results High triacylglycerol, apolipoprotein (Apo) B, ApoA-II and HDL 3 -cholesterol concentrations predicted incident microalbuminuria. Progression to macroalbuminuria was predicted by high triacylglycerol and ApoB. When AER was entered into the model, triacylglycerol was no longer an independent predictor, but when patients with normal AER and microalbuminuria at baseline were pooled, triacylglycerol, HbA 1c , male sex and AER were all independent predictors of renal disease. High total cholesterol, LDLcholesterol, non-HDL-cholesterol and triacylglycerol as well as low HDL-cholesterol, HDL 2 -cholesterol, ApoA-I and ApoA-II concentrations were predictive of progression to end-stage renal disease. However, when estimated GFR was entered into the model, only total cholesterol remained an independent predictor of progression. Conclusions/interpretation Lipid abnormalities, particularly high triacylglycerol concentrations, increase the risk of progression of renal disease.
Characteristics of the Lipid Profile in Patients with Diabetes Mellitus and Chronic Kidney Disease
Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2017
Background and aimsDiabetes mellitus (DM) is one of the leading causes of end-stage chronic kidney disease (CKD). Patients with DM and CKD have a 10 or even 20 times higher cardiovascular risk (CVR) than the general population. Lipid metabolism disorders are more frequent in these patients, dyslipidemia being aggravated by the presence of hyperglycemia and insulin resistance. The main purpose of our study was to identify possible correlations between lipid profile parameters and altered renal function in patients with DM. We have also analyzed the correlations between lipid parameters, CKD, quality of glycemic control and CVR.Material and method:The study was performed on 2732 patients with DM which received medical treatment and care at the Center for Diabetes Timisoara, for a 6-month period from March to October 2016, 1508 women (55.2%) and 1224 men (44.8%), mean age 63.7 ± 9.1 (33-78) years and mean diabetes duration 12.4 ± 6.8 (6-33) years. The study group included 312 patients ...
2020
Aims: To assess the relationship between estimated glomerular filtration rate (eGFR) and plasma lipid levels in non-dialysis diabetic kidney disease (ND-DKD) subjects. Materials and methods : In this cross-sectional study, outpatients from June to September 2020 who had been diagnosed with ND-DKD at Wahidin Sudirohusodo Hospital and Universitas Hasanuddin Hospital were enrolled. Creatinine was examined to determine eGFR based on the chronic kidney disease epidemiology collaboration (CKD-EPI) formulation, lipid profile, and metabolic characteristics. For statistical analysis, Pearson correlation test and Chi-Square test were performed, significant if the p < 0.05. Results : Of the 103 study participants analyzed with a mean age of 54,7 ± 9,1 years, it was found that the mean showed dyslipidemia, with plasma lipid levels in mg/dl were 254.1; 45.9; 156.2; 191.8 for total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), trigly...
Association between Lipid Profiles and Renal Functions among Adults with Type 2 Diabetes
International journal of diabetes and metabolism, 2019
Introduction: Type 2 diabetes mellitus (T2DM) affects renal functions and lipid profiles of patients. Objectives: In this study, 100 patients (65 females, 35 males) with T2DM were evaluated to determine whether renal function characteristics and lipid profiles are associated with T2DM. Methods: Blood samples were collected from all patients with T2DM, and the levels of hemoglobin A 1c (HbA 1c), blood urea, serum creatinine, cholesterol, triglyceride (TGR), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very lowdensity lipoprotein (VLDL) were analyzed. Results: A direct correlation of blood sugar and HbA 1c was observed with blood urea, serum creatinine, serum cholesterol, serum TGR, HDL, LDL, and VLDL. The results revealed elevated TGR levels in patients administered medications for hyperglycemia. Furthermore, serum TGR levels were significantly correlated with blood sugar levels (p = 0.035). Blood urea levels were significantly correlated with glycated hemoglobin (p = 0.008). Blood urea, serum creatinine, and serum cholesterol levels were highly significantly correlated with HbA 1c (p = 0.008, 0.017, and 0.005, respectively), while HDL, LDL, and VLDL were not significantly correlated with HbA 1c. Conclusion: This study highlights the importance of serum TGR and serum creatinine measurement for guiding the treatment of T2DM.
Diabetes & Obesity International Journal, 2017
Dyslipidemia is a common occurrence in type 2 diabetes mellitus (T2DM) patients and plays the major role in accelerated risk of cardiovascular disease (CVD) and possible causes chronic kidney disease (CKD), the progression of which leads to end-stage renal disease. A total of 266 T2DM patients were categorized into 2 groups according to their TG/HDL-C ratio of 2.5 and <2.5. The comparison of the clinical characteristics in these 2 groups demonstrated that Glucose, HbA1c, total Cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) levels, TG/HDL-C ratio were significantly higher, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) were significantly lower in the group with TG/HDL-C ratio 2.5 (p<0.05). Multiple logistic regressions demonstrated elevated TG/HDL-C ratio associated with CKD and increased HbA1c. The ORs and 95 % CIs were 4.94 (2.45, 9.96), 2.29 (1.13, 4.65) after adjusting for their covariates. Elevated TG/HDL-C ratio was associated with CKD and HbA1c and may increase the rate of disease progression and predict decline in kidney function and structural damage in these T2DM patients.
Collegium antropologicum, 2013
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We investigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 mL/min per 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r = -0.21, -0.18, and -0.17, respectively, for all p < 0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL...
A study of lipid profile in non-diabetic chronic kidney disease
International Journal of Advances in Medicine, 2016
Chronic Kidney Disease (CKD) is a worldwide health problem. Prevalence of CKD in the United States is increasing and affects about 19 million Americans. 1 The United States has seen a 30% increase in patients suffering from CKD in the last decade. 2 Over the last decade, it was established that CKD is associated with a very high mortality rate and accelerated Cardio-Vascular (CV) disease. 3 Recent studies suggest that the risk for death is increased in individuals with less severe impairment of kidney function that does not require dialysis when compared to those who have preserved kidney function. In patients who finally advance to ESRD ABSTRACT Background: The present study focused on finding an approximate prevalence of dyslipidemia in the target reference population and the association with staging and management strategy used. An effort was also made to know the alteration in different lipoprotein fractions in chronic kidney disease. The objective of the study was to study the lipid profile in non-diabetic patients with chronic kidney disease. Methods: The study was conducted in Ispat general hospital, Rourkela and data was collected from January 2014 to September 2015. Patients who were diagnosed with Chronic Kidney Disease admitted into the medical ward and dialysis unit of Ispat General Hospital, Rourkela, Odisha, who had willingly given their informed written consent for this study were the source of data. For diagnosis of CKD, history and clinical features with supportive biochemical and radiological evidence were taken as criteria. Patients with already known diabetes mellitus were excluded. Results: The prevalence of dyslipidemia in CKD was found to be about 65.%. And the prevalence was increasing with the increase in severity of the disease. There was a significant rise in the serum triglyceride concentration in the study population. This abnormality was followed by a fall in HDL cholesterol and rise in the total Serum cholesterol in patients suffering from CKD. On comparing patients with CKD on hemodialysis with that on conservative management there is a significant prevalence of dyslipidemia in the Hemodialysis group. There is a significantly higher level of triglycerides and Serum cholesterol and a significantly lower level of HDL cholesterol in the hemodialysis group. Conclusions: The high prevalence of lipid abnormalities in CKD may accelerate the progression of CVD and increase the mortality of patients. Hence it is worthwhile to test and detect patients at high risk early on and manage accordingly.
Lipid profile in Type 2 diabetes mellitus and in diabetic nephropathy
IP Innovative Publication Pvt. Ltd., 2017
Introduction: Diabetes mellitus (DM) is characterized by abnormalities of carbohydrate, protein and fat metabolism due to absolute or relative deficiency of insulin secretion, accompanied by varying degrees of resistance to insulin. Diabetes mellitus is currently the most common etiology for chronic kidney disease (CKD). Abnormalities of lipoprotein metabolism is associated with Diabetic nephropathy(DN), which can be influenced by derangement of renal function and the degree of metabolic control in diabetes mellitus. Our objective is to compare the levels of lipid profile, urine microalbumin and glycated haemoglobin (HbA1c) between type 2 Diabetes mellitus (T2DM) without any complications, T2DM with nephropathy and normal controls who were age and sex matched. Materials and Method: Study group consisted of 75 individuals of whom 25 were T2DM without any complications, 25 were T2DM with nephropathy and 25 were healthy controls. Total cholesterol (TC), Triglycerides(TG), LDL Cholesterol(LDL-c), HDL Chlolesterol (HDL-c), HbA1c and urine microalbumin were measured in these subjects. Results: The values of TC, TG, LDL-c, HbA1c and urine microalbumin levels were significantly higher in T2DM without any complications and T2DM with nephropathy when compared to controls. HDL-c level was significantly lower in T2DM without any complications and T2DM with nephropathy when compared to controls. Conclusions: T2DM and DN are associated with dyslipidemia which is more pronounced in diabetic nephropathy. Therefore, early detection of dyslipidemia in Type 2 diabetics and accordingly therapeutic intervention could control the resulting cardiovascular or renal complications.
International Journal of Advances in Medicine
Background: Chronic kidney disease (CKD) is a major health deteriorating factor worldwide as well as in India. It encompasses various pathophysiological processes involving abnormal kidney function and thereby declination in glomerular filtration rate (GFR). CKD is known risk factor for dyslipidemia. Due to lack of studies of association between different lipid parameters and its association with severity of CKD in non-diabetic patients in Indian population, we designed a study aimed to describe the serum lipid profile in non-diabetic CKD patients.Methods: This hospital based observational analytical was carried out in 60 subjects with CKD and non-diabetic. They were investigated for blood sugar parameters, lipid profile and renal function tests. Lipid profile was associated with different stages of CKD. Data was expressed as percentage and mean±SD.Results: Mean BMI was found to be 21.6±2.7kg/m2. Most common symptom encountered was H/o edema in 98% subjects. Out of total sixty subje...
https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.12\_Dec2020/Abstract\_IJRR0017.html, 2020
Objective: The main objective of the study was comparatively evaluation of serum lipid abnormalities in type 2 diabetes mellitus patients with or without diabetic nephropathy. Methods & materials: This is an observational study to explore the lipid abnormalities in diabetic patients with or without diabetic nephropathy. After taking patients consent demographic details like weight, height, age, weight were documented in a predesigned proforma and serological test was performed to identify , glycemic parameters like fasting blood glucose (FBG) , post prandial blood glucose (PPBG), glycated haemoglobin and serum lipid parameters like total cholesterol(TC), serum triglycerides (TG), Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Results: It was observed that both with and without nephropathy group had almost similar age group which was 52.7±9.79 and 53.4±9.35 years respectively. Between two groups there was no statistically significant difference (p value=0.823) as per age is concern. There were significant statistical differences in glycemic parameters and serial lipid parameters in-between the two groups. With nephropathy group, 70% of T2DM patients and without nephropathy group 44% of T2DM patients had dyslipidemia. Atherogenic dyslipidemia was observed 7% in diabetes with nephropathy group and 11% in without nephropathy group. In nephropathy group there were a higher percentage of subjects with dyslipidemia (p value=0.02). Conclusion: In the management of diabetes an important therapeutic target identified as dyslipidemia. Abnormal lipoprotein metabolism accelerates diabetic nephropathy which causes cardiovascular disease as well as the progression of diabetic nephropathy.