Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (original) (raw)
The Mad2 spindle checkpoint protein has two distinct natively folded states
Katja Wassmann
Nature Structural & Molecular Biology, 2004
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Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
Mario Faretta
The EMBO Journal, 2001
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The Mad2 spindle checkpoint protein has two distinct natively folded statesNSMB
Guohong Xia
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004
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Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
Katja Wassmann
Proceedings of the National Academy of Sciences, 2010
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Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer
Diana R Tomchick
PLOS Biology, 2008
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The Spindle Checkpoint Functions of Mad3 and Mad2 Depend on a Mad3 KEN Box-mediated Interaction with Cdc20-Anaphase-promoting Complex (APC/C
Anna Feoktistova
Journal of Biological Chemistry, 2008
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The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint
Marina Mapelli
Current Biology, 2005
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Checkpoint Signalling: Mad2 Conformers and Signal Propagation
Kevin Hardwick
Current Biology, 2005
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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex
Babhrubahan Roy
Nature Communications, 2023
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The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
Marina Mapelli
Cell, 2007
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MAD3 Encodes a Novel Component of the Spindle Checkpoint which Interacts with Bub3p, Cdc20p, and Mad2p
Dana Smith
Journal of Cell Biology, 2000
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Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores
Nicole Hustedt
EMBO reports, 2014
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Conformation-specific binding of p31 comet antagonizes the function of Mad2 in the spindle checkpoint
Guohong Xia
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Mitotic Checkpoint Proteins Mad1 and Mad2 – Structural and Functional Relationship with Implication in Genetic Diseases
Dan Mihailescu
Current Computer Aided-Drug Design, 2014
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BUBR1 and Closed MAD2 (C-MAD2) Interact Directly to Assemble a Functional Mitotic Checkpoint Complex
Laura Link
Journal of Biological Chemistry, 2011
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Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20
Daniele Fachinetti
Molecular Cell, 2013
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Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
Kevin Hardwick
Current Biology, 2000
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Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint
Kevin Hardwick
PLoS ONE, 2007
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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
Roberta Fraschini, Andrea Musacchio
The EMBO Journal, 2001
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Structure of the mitotic checkpoint complex
viviana dotolo
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Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes
Belinda Griffiths
Human Genetics, 2000
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Mad2-independent Spindle Assembly Checkpoint Activation and Controlled Metaphase-Anaphase Transition in Drosophila S2 Cells
Hassan Bousbaa
Molecular Biology of the Cell, 2007
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Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study)
Bashar Ibrahim
Biophysical Chemistry, 2008
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A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint
M. Moyle, Julien Espeut
The Journal of Cell Biology, 2014
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Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
Elsa Logarinho
Journal of Cell Biology, 2013
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Faculty of 1000 evaluation for Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
Jason Stumpff
F1000 - Post-publication peer review of the biomedical literature, 2000
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Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism
Farokh Dotiwala, Jacob Harrison
Current Biology, 2010
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Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex
ivana primorac
Science, 2009
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Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55
Elena Chiroli
The Journal of Cell Biology, 2013
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ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint
Jia Hao
Carcinogenesis, 2014
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Requirement for proteolysis in spindle assembly checkpoint silencing.
Luca Palazzo, R. Visconti
2010
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The spindle checkpoint: structural insights into dynamic signalling
Kevin Hardwick
Nature Reviews Molecular Cell Biology, 2002
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The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching
Walter Englander
The Journal of Cell Biology, 2008
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Faculty of 1000 evaluation for A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint
Kevin Hardwick
F1000 - Post-publication peer review of the biomedical literature, 2014
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The C-Terminal Half of Saccharomyces cerevisiae Mad1p Mediates Spindle Checkpoint Function, Chromosome Transmission Fidelity and CEN Association
Andrew Hong, Forrest Spencer
Genetics, 2005
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