Reversal of human cellular senescence: roles of the p53 and p16 pathways (original) (raw)
Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
Rene Bernards
Journal of Biological Chemistry, 2003
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Jesús Fominaya
Clinical and …, 2003
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Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
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Inactivation of p53 Function in Cultured Human Mammary Epithelial Cells Turns the Telomere-Length Dependent Senescence Barrier from Agonescence into Crisis
James Garbe
Cell Cycle, 2007
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Characterization of the p53 Response to Oncogene-Induced Senescence
Amancio Carnero
PLoS ONE, 2008
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Paradoxical suppression of cellular senescence by p53
Andrei Gudkov
Proceedings of the National Academy of Sciences, 2010
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Molecular Aspects of the Relationship between Cancer and Aging: Tumor Suppressor Activity During Cellular Senescence
Igor Garkavtsev
Experimental Gerontology, 1998
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Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
Gerardo Ferbeyre
Molecular and Cellular Biology, 2002
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Cellular senescence in the development and treatment of cancer
Gabriele Saretzki
Current pharmaceutical design, 2010
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An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence
Parmjit Jat
BMC Genomics, 2011
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Sequential Extension of Proliferative Lifespan In Human Fibroblasts Induced by Over-Expression of CDK4 or 6 and Loss of P53 Function.
Mark Morris
Oncogene, 2002
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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
Guy Poirier
The EMBO Journal, 1997
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Hallmarks of senescence in carcinogenesis and cancer therapy
Igor Roninson
Oncogene, 2004
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Senescence induction; a possible cancer therapy
Matilde Lleonart
Molecular Cancer, 2009
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Comparing the Role of the p53 Gene and Telomerase Enzyme in ‘Accelerated Aging Due to Cancer’: A Literature Review
Raheela Khalid
Cureus, 2020
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Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization
Lisa L Prigmore, PharmD
Journal of Biological Chemistry, 2004
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DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model
N. Puebla-Osorio
Journal of Experimental Medicine, 2007
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Senescence as a Target for Cancer Therapy
Matilde Lleonart
The Open Pathology Journal, 2008
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Novel ARF/p53-independent senescence pathways in cancer repression
Yuan Gao
Journal of Molecular Medicine, 2011
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P53 Isoforms Δ133P53 and P53Β Are Endogenous Regulators of Replicative Cellular Senescence
Giang Nguyen
Nature Cell Biology, 2009
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The Dual Role of Senescence in Tumorigenesis
Lilian Chuaire
International Journal of …, 2010
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Cellular senescence: hot or what?
Fabrizio Di Fagagna
Current Opinion in Genetics & Development, 2009
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage
Vassilis Zoumpourlis
2000
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Transcriptional regulation of cellular senescence
James Geraghty
Oncogene, 2011
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Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts
David Alcorta
Proceedings of The National Academy of Sciences, 1996
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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
Lynda Chin
Cell, 1999
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Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
Ying Luo
International Journal of Molecular Sciences, 2012
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Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells
Rosa Defilippis
Journal of Virology, 2004
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Rapid induction of senescence in human cervical carcinoma cells
Daniel Dimaio
Proceedings of the National Academy of Sciences, 2000
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Cellular senescence as a tumor-suppressor mechanism
Judith Campisi
Trends in Cell Biology, 2001
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Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy
Ana Preto
Oncogene, 2004
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Senescence; an endogenous anticancer mechanism
JOSE ALEJANDRO
2012
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A Senescence Program Controlled by P53 and P16INK4a Contributes to the Outcome of Cancer Therapy
Jordan Fridman
Cell, 2002
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Soothing the Watchman: Telomerase Reduces the p53-dependent Cellular Stress Response
Paul Yaswen
Cell Cycle, 2007
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What is and what is not cell senescence
Grażyna Mosieniak
Postepy biochemii, 2018
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