Reversal of human cellular senescence: roles of the p53 and p16 pathways (original) (raw)

Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53

Rene Bernards

Journal of Biological Chemistry, 2003

View PDFchevron_right

Exploring cellular senescence as a tumor suppressor mechanism

Jesús Fominaya

Clinical and …, 2003

View PDFchevron_right

Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines

Paul Yaswen

Oncogene, 2003

View PDFchevron_right

Inactivation of p53 Function in Cultured Human Mammary Epithelial Cells Turns the Telomere-Length Dependent Senescence Barrier from Agonescence into Crisis

James Garbe

Cell Cycle, 2007

View PDFchevron_right

Characterization of the p53 Response to Oncogene-Induced Senescence

Amancio Carnero

PLoS ONE, 2008

View PDFchevron_right

Paradoxical suppression of cellular senescence by p53

Andrei Gudkov

Proceedings of the National Academy of Sciences, 2010

View PDFchevron_right

Molecular Aspects of the Relationship between Cancer and Aging: Tumor Suppressor Activity During Cellular Senescence

Igor Garkavtsev

Experimental Gerontology, 1998

View PDFchevron_right

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Gerardo Ferbeyre

Molecular and Cellular Biology, 2002

View PDFchevron_right

Cellular senescence in the development and treatment of cancer

Gabriele Saretzki

Current pharmaceutical design, 2010

View PDFchevron_right

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

Parmjit Jat

BMC Genomics, 2011

View PDFchevron_right

Sequential Extension of Proliferative Lifespan In Human Fibroblasts Induced by Over-Expression of CDK4 or 6 and Loss of P53 Function.

Mark Morris

Oncogene, 2002

View PDFchevron_right

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

Guy Poirier

The EMBO Journal, 1997

View PDFchevron_right

Hallmarks of senescence in carcinogenesis and cancer therapy

Igor Roninson

Oncogene, 2004

View PDFchevron_right

Senescence induction; a possible cancer therapy

Matilde Lleonart

Molecular Cancer, 2009

View PDFchevron_right

Comparing the Role of the p53 Gene and Telomerase Enzyme in ‘Accelerated Aging Due to Cancer’: A Literature Review

Raheela Khalid

Cureus, 2020

View PDFchevron_right

Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization

Lisa L Prigmore, PharmD

Journal of Biological Chemistry, 2004

View PDFchevron_right

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model

N. Puebla-Osorio

Journal of Experimental Medicine, 2007

View PDFchevron_right

Senescence as a Target for Cancer Therapy

Matilde Lleonart

The Open Pathology Journal, 2008

View PDFchevron_right

Novel ARF/p53-independent senescence pathways in cancer repression

Yuan Gao

Journal of Molecular Medicine, 2011

View PDFchevron_right

P53 Isoforms Δ133P53 and P53Β Are Endogenous Regulators of Replicative Cellular Senescence

Giang Nguyen

Nature Cell Biology, 2009

View PDFchevron_right

The Dual Role of Senescence in Tumorigenesis

Lilian Chuaire

International Journal of …, 2010

View PDFchevron_right

Cellular senescence: hot or what?

Fabrizio Di Fagagna

Current Opinion in Genetics & Development, 2009

View PDFchevron_right

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

Vassilis Zoumpourlis

2000

View PDFchevron_right

Transcriptional regulation of cellular senescence

James Geraghty

Oncogene, 2011

View PDFchevron_right

Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts

David Alcorta

Proceedings of The National Academy of Sciences, 1996

View PDFchevron_right

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Lynda Chin

Cell, 1999

View PDFchevron_right

Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction

Ying Luo

International Journal of Molecular Sciences, 2012

View PDFchevron_right

Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

Rosa Defilippis

Journal of Virology, 2004

View PDFchevron_right

Rapid induction of senescence in human cervical carcinoma cells

Daniel Dimaio

Proceedings of the National Academy of Sciences, 2000

View PDFchevron_right

Cellular senescence as a tumor-suppressor mechanism

Judith Campisi

Trends in Cell Biology, 2001

View PDFchevron_right

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy

Ana Preto

Oncogene, 2004

View PDFchevron_right

Senescence; an endogenous anticancer mechanism

JOSE ALEJANDRO

2012

View PDFchevron_right

A Senescence Program Controlled by P53 and P16INK4a Contributes to the Outcome of Cancer Therapy

Jordan Fridman

Cell, 2002

View PDFchevron_right

Soothing the Watchman: Telomerase Reduces the p53-dependent Cellular Stress Response

Paul Yaswen

Cell Cycle, 2007

View PDFchevron_right

What is and what is not cell senescence

Grażyna Mosieniak

Postepy biochemii, 2018

View PDFchevron_right