Anti-hyperglycaemic potential of Psidium guajava raw fruit peel (original) (raw)
Related papers
Journal of Basic Medical Veterinary, 2024
Background:The chronic disease known as diabetes mellitus is brought on by either the pancreas's inability to make enough insulin or the body's inability to use it. Purpose:This plant finds applications for treating diarrhea, dysentery, gastroenteritis, hypertension, diabetes, caries and pain relief. Purpose:The current study aimed to determine how Psidium guajavafruit extract affected the blood glucose, body weights, and insulin levels of streptozotocin (STZ)-induced diabetic rats over 21 days. Methods:The extract's effectiveness was compared to that of glibenclamide, a common hypoglycemic medication. 30 male Wistar albino rats were divided into 5 groups with 6 animals in each group. V: Normal control (Group-I), diabetic control (Group-II), diabetic rats treated with glibenclamide 0.6mg/kg bw (Group-III), diabetic rats treated with Psidium guajavafruit extract 200 mg/kg bw (Group-IV) and Psidium guajavafruit extract 400 mg/kg bw (Group-V). All group of rats were subjected to evaluation of body weight, blood glucose and serum insulin levels on day 0, 7, 14 and 21 of the experiment. Results:There was significant (P<0.05) decrease in body weight and serum insulin and significant (P<0.05) increase in blood glucose level in Group-II compared to Group-I rats. In the Present study, daily oral administration of Psidium guajavafruit extract at dose rate of 200 and 400 mg/kg bw and glibenclamide at 0.6mg/kg bw in diabetic rats for 21 days showed a progressive improvement in body weight, blood glucose and serum insulin concentration. Conclusion:It can therefore be concluded the results of this study indicate that Psidium guajavafruit extract possesses anti-diabetic properties in Wistar albino rats
Background: Psidium guajava L (Guava) belongs to the Myrtaceae family and has been claimed to possess several pharmacological properties including antidiabetic. Objective: This study was designed to evaluate the anti-hyperglycemic activity of P guajava L leaves aqueous extract on neonatal streptozotocin-induced type 2 diabetic model rats. Methods: Streptozotocin was induced (90 mg/kg) intraperitoneally to 48 h old Long Evans rat pups. After three months, 18 male type-2 diabetic model rats were confirmed by OGTT (FG > 7 mmol/L). Therefore, experimental rats were divided into three groups 2) Diabetic water control (10 ml/kg), 3) Gliclazide treated (20 mg/kg), and 4) Extract treated group (1.25g/kg)] Six normal female rats comprised group 1 [Non-diabetic water control (10 ml/kg)]. All rats were treated orally with their respective treatment for 28 consecutive days. Blood samples were collected on 0 days (by tail cut method) and the end day (by cardiac puncture) of the experiment. The anti-hyperglycemic activity was evaluated by measuring fasting glucose, serum insulin, lipid profile, hepatic glycogen content, and intestinal glucose absorption by standard methods. Results: The serum glucose level of extract treated group was decreased by 16% as well as significantly (p<0.05) increased the serum insulin level (M±SD, 0 day vs 28thday; 0.319 ± 0.110 vs 0.600 ± 0.348, mg/L). Moreover, the extract-treated group also significantly (p<0.05) enhanced liver glycogen content and inhibited glucose absorption from the upper intestine. Besides, a significant (p < 0.05) reduction of LDLcholesterol level was found in the extract-treated group (M±SD, 55 ± 33 vs 14 ± 9, mg/dl) compared with baseline values where other groups did not show any statistically remarkable changes. Conclusion: Current study concludes that P guajava leaves aqueous extract enhances insulin secretion from pancreatic beta-cells and promotes glycogen synthesis in the liver. The extract also inhibits glucose absorption from the upper intestine and improves dyslipidemia to some extent. Therefore, possesses the potential for drug development against T2DM.
Plant Foods for Human Nutrition, 2010
Hyperglycemia causes increased protein glycation and the formation of early glycation products and advanced glycation end products (AGEs) which are major factors responsible for the complications associated with diabetes. The aim of the present study was to investigate the antioxidant as well as antiglycative potential of ethyl acetate fraction of guava leaves. Oral administration of the extract at different doses showed a significant decrease in blood glucose level. It also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase. Glycated hemoglobin as well as fructosamine which are indicators of glycation was also reduced significantly in treated groups when compared to diabetic control. In vitro studies also support the antioxidant as well as antiglycative potential of guava leaves.
Sains Malaysiana, 2013
Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P. guajava fruit peel aqueous extract on oxidative stress of pancreas in streptozotocin-induced (45 mg/kg) diabetic rats. Diabetic rats were administered with 400 mg/kg of aqueous extract of P. guajava fruit peel daily for 28 days duration. The results showed that diabetic rats supplemented with P. guajava extract did not cause significant difference in blood glucose level (p>0.05) as compared with diabetic rats alone. For oxidative stress evaluation, malondialdehyde (MDA) and protein carbonyl level were significantly lower and the activity of superoxide dismutase (SOD) and glutathione (GSH) level were significantly higher (p<0.05) in P. guajava supplemented rats compared with non-sup...
The Egyptian Journal of Hospital Medicine
The present aim is to evaluate the anti-diabetic effect of aqueous extract of guava (Psidium guajava) leaf using rat model of diabetes induced by streptozotocin. In addition, the effect of this extract on liver and kidney functions induced in rat model of diabetes were investigated. Material and Methods: Rats were divided randomly into: control group, rat model of diabetes induced by streptozotocin, rat model of diabetes treated with aqueous extract of guava leaf, rat model of diabetes treated with glibenclamide and rat model of diabetes treated with aqueous extract of guava leaf plus glibenclamide. Result: In the present rat model of diabetes a significant decrease in the serum insulin level and a significant increase in glucose level were detected. Streptozotocin induced a significant increase in the activities of AST, ALT, ALP and a significant increase in the levels of bilirubin, urea, creatinine and uric acid. In addition histopathological and immunological changes were detected in the pancreatic tissue. The present data revealed that aqueous extract of guava leaf improved the reduced insulin level and the high glucose level induced by streptozotocin. This was associated with an improvement in the changes in the liver and kidney functions. Loss of body weight gain induced by streptozotocin was alleviated by guava leaf extract, glibenclamide or both. Conclusion: According to the present findings it could be concluded that the aqueous extract of guava leaf has a potent anti-hyperglycemic effect on rat model of diabetes induced by streptozotocin with hepatic and renal protective effects.
Anti-hyperglycemic Activity of Psidium guajava Bark Extract
Journal of Natural Remedies, 2004
Objective: To evaluate the anti-hyperglycemic activity of water extract of Psidium guajava stem bark. Materials and methods: The water extract of stem bark of Psidium guajava was tested for its hypoglycemic activity in normal glucose loaded and alloxan-induced hyperglycemic Wistar rats. Blood glucose levels were evaluated at intervals of 30 and 90 minutes in normal glucose loaded animals, at intervals of 0, 1 and 3 h in acute study and at days 1, 3, 7 and 10 during sub acute treatment after extract administration at an oral dose of 250 mg/kg. Results: During both acute and sub-acute tests, the water extract showed statistically significant and considerable anti-hyperglycemic activity and enhanced glucose tolerance in normal glucose loaded rats. Conclusion: Psidium guajava stem bark possessed statistically significant anti-hyperglycemic potential in alloxan induced diabetic rats and enhanced glucose tolerance in glucose loaded normal rats.
Effect of Ethanolic Leaf Extract of Psidium guajava Linn. (Guava) in Alloxan-Induced Diabetic Rats.
British Journal of Pharmaceutical Research., 2017
Effect of water – soluble components of ethanolic leaf extract of Psidium guajava Linn. on blood glucose and cholesterol levels in alloxan-induced diabetic male albino wistar rats was evaluated. A total of 30 male albino wistar rats were randomized into 4 groups. Ten (10) animals each were randomly assigned to groups 1 and 2 and 5 each for groups 3 and 4. Group 1 animals were induced with 150 mg of alloxan/kg body weight of animal, after which they were administered 400 mg of extracts/kg body weight of animal. Group 2 animals serving as diabetic control were administered only 150 mg of alloxan/kg body weight of animal, no extract was given. Group 3 animals received only 400 mg of extract/kg body weight of animal while Group 4 animals served as normal control and were given distilled water in place of the extract. Extracts were administered twice daily and treatments lasted for 10 consecutive days. Blood samples were collected for analysis every two days from the tail tips of the rats. Results obtained showed that there were significant (p < 0.05) reductions in blood glucose and cholesterol levels in the diabetic treated rats (Group 1) when compared with the diabetic control rats (Group 2). However, administration of the extract did not show any hypoglycaemic effect on the normal rats (p ˃ 0.05) compared with the control. The results suggest that leaf extract of P. guajava Linn. is antihyperglycaemic and not hypoglycaemic. In view of the fact that it also showed significant antihypercholesterolaemia, P. guajava Linn. may be a potential antidiabetic agent.
Over the past decade, herbal medicine have been accepted universally and they have an impact on both world health and international trade. Diabetes mellitus is a metabolic disorder in the endocrine system. Plants provide a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes.Qualitative phytochemical analysis of aqueous extract of flower of psidium guajava was carried out with a view of developing leads for a new therapeutic products. The study was designed to investigate the hypoglycaemic effects of oral administration of aqueous extracts of psidium guajava flower in alloxan induced diabetic rats. After oral administration of the flower extract to diabetic rats, the blood glucose level significantly reduced, which is much faster and more than that of metformin. The aqueous extracts of flower of psidium guajava significantly reduced plasma glucose, creatinine, urea, AST, ALT, ACP, ALP, LPO, glucose-6- phosphatase and fructose1,6 bisphosphatase but increased level of serum insulin, protein, CAT, SOD, glycogen synthase and hexokinase. For all the above biochemical parameters observed and it was reverted toits normal level after flower extract treatment. The present investigation suggests that flowers of psidium guajava exhibit hypoglycaemic activity in alloxan induced diabetes in experimental rats.
pharmacologyonline.silae.it
The antihyperglycaemic activity of the ethanol extract of Psidium guajava (EEPG) leaves was studied by administering three doses of EEPG (i. e.100,200 and 400 mg/kg, p. o.) to alloxan (70 mg/kg, i. v.) induced diabetic mice. The serum glucose levels and body weights of mice were determined. The acute oral toxicity study showed no mortality upto 5000 mg/kg p. o. dose of EEPG. In acute study the antihyperglycaemic effect was observed at 2h (78.25 mg/dl), peak at 6 h (197.03 mg/dl) but antihyperglycaemic effect vanished at 24 h. The subacute study was also carried out which showed maximum reduction in serum glucose level (311.22 mg/dl) at the dose of 200 mg/kg on 28 th day. The oral glucose tolerance test (OGTT) was carried out after administration of EEPG in non-diabetic and diabetic mice previously loaded with (2.5 g/kg, p. o.) glucose. EEPG (200 mg/kg) showed increased glucose threshold in non-diabetic mice. EEPG (800 mg/kg) showed increased glucose threshold in diabetic mice. EEPG (200 mg/kg) prevented the loss of body weight. These results indicated antihyperglycaemic activity of EEPG (200 mg/kg) in alloxan induced diabetic mice. The antihyperglycaemic activity of EEPG was comparable with glyburide.
Delta Medical College Journal, 2017
Background: Diabetes Mellitus is a major health problem not only in urban but also in the rural areas of Bangladesh. Regarding its treatment, a suitable drug is yet to be available which can permanently cure this disease. Over 400 traditional plants have been reported for the treatment of diabetes, but only a small number have received scientific and medical evaluation to assess their efficacy. Objective: The study was performed to compare the anti diabetic effect of Psidium guajava Linn leaves with an oral anti diabetic drug (Glibenclamide), in experimentally induced diabetic rats.