Analgesic And Anti-Inflammatory Properties Of Aqueous Extract From Leaves Of Solanum torvum (Solanaceae) (original) (raw)
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Evidence-based complementary and alternative medicine : eCAM, 2011
The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of in...
Analgesic and anti-inflammatory properties of leaf extract
Journal of Ethnopharmacology, 2005
The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.
African Journal of Traditional, Complementary and Alternative Medicines, 2008
Solanum torvum is used in Cameroonian traditional medicine for the management of pain and inflammation. The present work assesses the pain-killing and anti-inflammatory properties of the aqueous extracts of Solanum torvum leaves. Acetic acid-and pressure-induced pains were reduced by this extract while carrageenan-induced inflammation was inhibited at various doses of the extract. The extract therefore has both analgesic and anti-inflammatory properties.
Antinociceptive Activity of Methanol Extract of Dioscorea Pentaphylla Linn. Leaves in Mice
Background: Dioscorea pentaphylla L. a common plant of Dioscorea family commonly called five leaves in Bangladesh. The plant contains the alkaloid, carbohydrate, tannin, gum protein, steroid, glycoside, flavonoids. It is used as an analgesic, anti-inflammatory, and Powder of plant extract given orally in abdominal pain after delivery. The aim of the study: The present study was designed to evaluate chemical constituents and to investigate the antinociceptive activity of methanol extracts of Dioscorea pentaphylla (MEDP). Methods: The antinociceptive activity of MEDP was investigated using heat-induced (hot-plate and tail-immersion test) and chemical-induced (acetic acid, Formalin-induced) nociception models in mice at 200 & 400mg/kg doses. Result: Oral administration of the methanolic extract of leaves of Dioscorea pentaphylla L. (200 & 400 kg/mg) dose-dependently reduced nociceptive response to acute pain in acetic acid induced writhing. For acetic acid-induced writhing test highest inhibition (55.40 %) was found in case of highest dose (400 mg/kg) for leaf extract. Whereas standard drug diclofenac sodium causes (46.93%) writhing inhibition. Formalin-induced nociception test showed the significant effect in (200 and 400 mg/kg) for both dosages. On the other hand, MEDP showed the significant effect in hot plate, tail immersion test, at high dose (400mg/kg). Conclusion: MEDP showed significant antinociceptive activity via a multifactorial mechanism of action, indicating that the extract may be useful in the development of a new analgesic drug.
Comparative Analgesic Activity of Selected Solanum Species
PLANT ARCHIVES, 2021
Synthetic analgesic drugs have prominent side effects like gastritis, gastric ulcer, kidney disorder and cardiac arrhythmias. The genus Solanum has been primarily used for various therapeutic effects, mainly analgesics, in the indigenous system of medicine. The current research aimed to investigate and compare the analgesic activities of methanolic extracts of leaves of Solanum indicum, Solanum surattense and Solanum torvum. Using acetic acid induced writhing method and hot plate method, the analgesic activity was evaluated. Significant anti-nociceptive effects were observed on both animal models after the application of different doses of the extracts of Solanum species. The results exhibited that MESI, MESS and MEST at a dose of 200 and 400 mg/kg produced analgesic effects equivalent to diclofenac (10 mg/kg). However the extracts at 400 mg/ kg exhibited more pronounced analgesic activity. The results of this study demonstrated that the analgesic effects of all the three species we...
Phytomedicine, 2014
Diospyros lotus L. is traditionally used in various diseases including pain and sleep disorders. The pain and inflammation are the common problems, which are treated with various synthetic analgesic drugs, and associated the side effects. The natural products have gained significant importance over synthetic drugs. The importance of phyto-medicine the current study has been designed with the aim to investigate the analgesic and anti-inflammatory effects of Diospyros lotus and bioassay guided isolation from its crude fractions. Seven known compounds; lupeol (1), 7-methyljuglone (2), ˇ-Sitosterol (3), stigmasterol (4) betulinic acid (5), diospyrin (6; DS) and 8-hydroxyisodiospyrin (7; HDS) which were hitherto unreported from D. lotus. The chloroform fraction (CFDL) and isolated compounds DS and HDS were evaluated for anti-nociceptive, sedative and anti-inflammatory effects. The acetic acid induced writing was significantly (p < 0.001) protected by CFDL (72.43%), DS (40.87%) and HDS (65.76%) at higher doses which exhibited peripheral and central analgesic effects in acetic acid and hot-plat pain paradigms. Regarding the antiinflammatory effect the CFDL (77.43%), DS (80.54%) and HDS (75.87%) protected the carrageenan paw edema after 3rd h. The central analgesic effect was significantly antagonized with naloxone (0.5 mg/kg), showing opiodergic mechanism of action. The CFDL, DS and HDS were also proved sedative in open field animal models. In acute toxicity study the chloroform fraction [CFDL (50, 100 and 150 mg/kg)], DS (5 and 10 mg/kg) and HDS (5 and 10 mg/kg) were found safe.
Phytochemical screening and evaluation of analgesic activity of Solanum surattense
The leaves of the medicinal plant Solanum surattense (Family-Solancceae) were extracted in 95% ethanol to evaluate centrally acting analgesic potential at two different doses, (250 and 500 mg/kg body weight). Three different test methodologies; hot plate test, acetic acid induced writhing test and formalin test were employed to assess the analgesic activity. A significant analgesic activity of the extract was observed in mice; 39.34% and 60.47% (P<0.05 and P<0.001) protection against thermal-induced pain, 33.98% and 49.59% (P<0.001), protection against acetic acid-induced writhing and 40.00% and 67.80% (P<0.05 and P<0.001) protection against formalin induced pain. The crude extract of the plant was found to have significant (p<0.05) analgesic activity at the dose of 250 and 500 mg/kg that suggests the presence of active principles in the extract responsible for analgesic activity.
2016
Submitted 18 Nov 2016; Accepted 27 Dec 2016; Published 5 Jan 2017 Physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. The present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. Acetic acid-induced abdominal contraction or writhing analgesic models in Swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200, 300 and 400 mg/kg body weight of the extract were administered intraperitoneally. Analgesic activities of the extract were compared with standard reference drug ibuprofen (100 mg/kg) and negative control. The plant extract showed a significant dose dependent analgesic effect, with 72.7% inhibition at 400 mg/kg compared to that of the 100 mg/kg standard drug ibuprofen which showed 21.2% inhibition (P< 0.05). The anti-inflammatory activity of the extract against carrageenan-induced paw edema was also dose-dependent with 62.71%...
Evaluation of anti-inflammatory and analgesic activity of root extract of Solanum trilobatum Linn
Iranian Journal of …, 2009
The aim of the present study was to evaluate the anti-inflammatory and analgesic activity of the aqueous methanolic extract of the root of Asparagus racemosus in Albino mice model. Oedema models were induced by injection of carrageenan and fresh egg albumin into right hind paw. Acetic acid and formalin were used to induce pain models. The aqueous methanolic extract showed significant reduction in both paw oedema models. In pain models, the extract also significantly inhibited the acetic acid-induced writhing and formalin-induced paw lickings. Our findings showed that aqueous methanolic extract of Asparagus racemosus's root reduced inflammation and pain in experimental models. The results proposed a potential use of Asparagus racemosus's roots in treating conditions associated with inflammation and pain. Rezumat Scopul studiului a fost de a evalua activitatea antiinflamatorie și analgezică a extractului hidroalcoolic din rădăcina de Aspraragus racemosus într-un model experimental murin. Edemul a fost indus prin injectarea de carragenan și albumină proaspătă din ou în laba dreaptă din spate. S-au folosit acid acetic și formalină pentru a induce modele de durere. Extractul hidroalcoolic a demonstrat o reducere semnificativă a ambelor modele de edem de labă. În modelele de durere, extractul inhibă, de asemenea, în mod semnificativ simptomatologia specifică fiecărui test. Constatările noastre au arătat că extractul hidroalcoolic din rădăcina de Aspraragus racemosus a redus inflamația și durerea în modelele experimentale testate. Rezultatele au sugerat o posibilă utilizare a rădăcinilor Aspraragus racemosus în tratarea afecțiunilor asociate cu inflamația și durerea.
Anti-inflammatory and Diuretic Activities of Ethanol Extract of Dioscorea bulbifera Leaf
Journal of Drug Delivery and Therapeutics, 2015
Objective: The present study was designed to determine the anti-inflammatory and diuretic activities of the plant Dioscorea bulbifera . In the anti-inflammatory study, thirty two animals were used and they were randomly distributed four animals per group. Method: Administered concentration of Dioscorea bulbifera were 500mg/kg, 250mg/kg, 125mg/kg, 62.5mg/kg and 31.25mg/kg, 15.5mg/kg were given to the test group labeled group A to F. A negative control receiving normal saline at 0.9mg/kg and a positive control receiving aspirin at 100mg/kg were as control groups for the study. Egg albumin was used as the inflammatory agent. Result: The negative control showed no inhibition. Further results showed that the concentration at 500mg/kg of the ethanol extract had the highest anti-inflammatory effect at 20.4 ± 0.14. In the diuretic study, the negative control containing the normal saline and the positive control containing furosemide were used. The albino rats were administered the extracts ...