Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules (original) (raw)

Bioorganic & Medicinal Chemistry Letters, 2013

Novel "anti-reverse" cap analogs with superior translational properties

2003

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

Cell cycle (Georgetown, Tex.), 2018

Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P, P-Tri-, P, P-Tetra-, and P, P-Pentaphosphates

Ryszard Stolarski

Nucleos Nucleot Nucleic Acids, 2003

Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency

Ryszard Stolarski

RNA, 2004

Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P 1 , P 3 -Tri-, P 1 , P 4 -Tetra-, and P 1 , P 5 -Pentaphosphates

Nucleosides, Nucleotides and Nucleic Acids, 2003

Synthesis of Anti-Reverse Cap Analogs (ARCAs) and their Applications in mRNA Translation and Stability

2007

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

Bioorganic & Medicinal Chemistry, 2012

SYNTHESIS AND PROPERTIES OF mRNA CAP ANALOGS CONTAINING PHOSPHOROTHIOATE MOIETY IN 5′,5′-TRIPHOSPHATE CHAIN

Jacek Jemielity, Ryszard Stolarski

Nucleosides, Nucleotides and Nucleic Acids, 2005

Synthesis of the first double-functionalized dinucleotide mRNA cap analogue for its specific labeling

Tetrahedron Letters, 2017

Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG

Ryszard Stolarski

RNA (New York, N.Y.), 2001

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

RNA, 2007

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

Marcin Warmiński

ACS Chemical Biology, 2021

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

Marcin Warmiński

Nucleic acids research, 2017

N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering

RNA

Quantitative Assessment of mRNA Cap Analogues as Inhibitors of in Vitro Translation †

Lidia Chlebicka, Ryszard Stolarski

Biochemistry, 1999

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

Marcin Ziemniak, Jacek Jemielity

2013

Inhibition of eukaryotic translation by analogs of messenger RNA 5'-cap: chemical and biological consequences of 5'-phosphate modifications of 7-methylguanosine 5'-monophosphate

Irena Ekiel

Biochemistry, 1987

Fluorescence and NMR studies of intramolecular stacking of mRNA cap-analogues

Lidia Chlebicka, Ryszard Stolarski

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1997

Decapping Scavenger Enzyme Activity toward N2-Substituted 5′ End mRNA Cap Analogues

ACS Omega, 2019

Insertion of an N7-methylguanine mRNA Cap between Two Coplanar Aromatic Residues of a Cap-binding Protein Is Fast and Selective for a Positively Charged Cap

Ah-lim Tsai

Journal of Biological Chemistry, 2003

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

New Journal of Chemistry, 2010

5′-Terminal chemical capping of spliced leader RNAs

Tetrahedron Letters, 2012

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

Marcin Ziemniak, Jacek Jemielity

Bioorganic & Medicinal Chemistry Letters, 2009

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

RNA, 2011

Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures

Yasuaki Kimura

2022

Inhibition of eukaryotic translation by nucleoside 5'-monophosphate analogs of mRNA 5'-cap: changes in N7 substituent affect analog activity

Irena Ekiel

Biochemistry, 1989

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors

RNA, 2014

Potential therapeutic applications of RNA cap analogs

Future medicinal chemistry

Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine

Peter Haeberli

Nucleic Acids Research, 2005

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

Jacek Jemielity, Remigiusz Worch

RNA, 2005

Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

Jacek Jemielity, Ryszard Stolarski

Bioorganic & Medicinal Chemistry, 2006