Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG (original) (raw)

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation

Jacek Jemielity

Bioorganic & Medicinal Chemistry Letters, 2013

View PDFchevron_right

Synthesis of Anti-Reverse Cap Analogs (ARCAs) and their Applications in mRNA Translation and Stability

Jacek Jemielity

2007

View PDFchevron_right

SYNTHESIS AND PROPERTIES OF mRNA CAP ANALOGS CONTAINING PHOSPHOROTHIOATE MOIETY IN 5′,5′-TRIPHOSPHATE CHAIN

Jacek Jemielity, Ryszard Stolarski

Nucleosides, Nucleotides and Nucleic Acids, 2005

View PDFchevron_right

Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency

Ryszard Stolarski

RNA, 2004

View PDFchevron_right

Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P, P-Tri-, P, P-Tetra-, and P, P-Pentaphosphates

Ryszard Stolarski

Nucleos Nucleot Nucleic Acids, 2003

View PDFchevron_right

Synthesis of Novel mRNA 5′ Cap-Analogues: Dinucleoside P 1 , P 3 -Tri-, P 1 , P 4 -Tetra-, and P 1 , P 5 -Pentaphosphates

Jacek Jemielity

Nucleosides, Nucleotides and Nucleic Acids, 2003

View PDFchevron_right

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

Jacek Jemielity

RNA, 2007

View PDFchevron_right

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps

Marcin Warmiński

Topics in current chemistry (Journal), 2017

View PDFchevron_right

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

Jacek Jemielity

Bioorganic & Medicinal Chemistry, 2012

View PDFchevron_right

Inhibition of eukaryotic translation by analogs of messenger RNA 5'-cap: chemical and biological consequences of 5'-phosphate modifications of 7-methylguanosine 5'-monophosphate

Irena Ekiel

Biochemistry, 1987

View PDFchevron_right

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

Jacek Jemielity

RNA, 2011

View PDFchevron_right

Novel "anti-reverse" cap analogs with superior translational properties

Jacek Jemielity

2003

View PDFchevron_right

Methyl esterification of m7G5′p reversibly blocks its activity as an analog of eukaryotic mRNA 5′-caps

Irena Ekiel

Journal of Molecular Biology, 1981

View PDFchevron_right

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N7)-methyl transferase

Francois Morvan

RNA, 2012

View PDFchevron_right

Synthesis of the first double-functionalized dinucleotide mRNA cap analogue for its specific labeling

Karolina Piecyk

Tetrahedron Letters, 2017

View PDFchevron_right

Translational discrimination of ‘capped’ and ‘non-capped’ mRNAS: inhibition by a series of chemical analogs of m7GpppX

Dan Canaani

FEBS Letters, 1976

View PDFchevron_right

High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions

Barbara Selisko

Nucleic Acids Research, 2007

View PDFchevron_right

High-yield production of short GpppA- and 7Me GpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-20O positions

Barbara Selisko

Nucleic Acids Research

View PDFchevron_right

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

Jacek Jemielity

New Journal of Chemistry, 2010

View PDFchevron_right

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

Karolina Piecyk

Cell cycle (Georgetown, Tex.), 2018

View PDFchevron_right

Synthetic mRNAs with superior translation and stability properties

Jacek Jemielity

2013

View PDFchevron_right

Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

Jacek Jemielity, Ryszard Stolarski

Bioorganic & Medicinal Chemistry, 2006

View PDFchevron_right

Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

Jacek Jemielity

Organic & Biomolecular Chemistry, 2014

View PDFchevron_right

5′-Terminal chemical capping of spliced leader RNAs

Karolina Piecyk

Tetrahedron Letters, 2012

View PDFchevron_right

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

Marcin Warmiński

Nucleic acids research, 2017

View PDFchevron_right

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

Jacek Jemielity

RNA, 2008

View PDFchevron_right

Quantitative Assessment of mRNA Cap Analogues as Inhibitors of in Vitro Translation †

Lidia Chlebicka, Ryszard Stolarski

Biochemistry, 1999

View PDFchevron_right

N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering

Karolina Piecyk

RNA

View PDFchevron_right

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Marcin Ziemniak

Nucleic acids research, 2014

View PDFchevron_right

Insertion of an N7-methylguanine mRNA Cap between Two Coplanar Aromatic Residues of a Cap-binding Protein Is Fast and Selective for a Positively Charged Cap

Ah-lim Tsai

Journal of Biological Chemistry, 2003

View PDFchevron_right

Triple-strand-forming methylphosphonate oligodeoxynucleotides targeted to mRNA efficiently block protein synthesis

Mark A Reynolds

Proceedings of the National Academy of Sciences of the United States of America, 1994

View PDFchevron_right

Inhibition of eukaryotic translation by nucleoside 5'-monophosphate analogs of mRNA 5'-cap: changes in N7 substituent affect analog activity

Irena Ekiel

Biochemistry, 1989

View PDFchevron_right

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

Marcin Ziemniak, Jacek Jemielity

Bioorganic & Medicinal Chemistry Letters, 2009

View PDFchevron_right