Childhood primary hepatocellular carcinoma and hepatitis B virus infection (original) (raw)
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Hepatitis B related childhood hepatocellular carcinoma. Childhood hepatic malignancies
Cancer, 1987
The case of hepatocellular carcinoma (HCC) with foci of hepatoblastoma in a 7-year-old boy, the son of a hepatitis B surface antigen (HBsAg) carrier mother, is described. Twelve other malignant liver tumors in children were also reviewed for HBsAg and hepatitis B core antigen (HBcAg). Both were negative in all (nine) hepatoblastomas. One of three HCC demonstrated positivity for HBsAg. These cases illustrate the importance of hepatitis B virus infection in early childhood and stress the need for careful screening in pregnant women, irrespective of ethnic backgrounds.
Primary hepatocellular carcinoma and hepatitis B infection during childhood
Hepatology, 1987
Twenty pediatric patients with primary hepatocellular carcinoma in Taiwan were tested for HBsAg, and all were found to be positive. The youngest case was 8 months of age, five cases occurred between 9 and 10 years of age, and 14 cases occurred between 11 and 16 years of age. The serum a-fetoprotein was elevated in all 20 primary hepatocellular carcinoma patients, and the average survival of these cases after diagnosis was 4.7 months. Seventy per cent of the mothers of the pediatric primary hepatocellular carcinoma cases and 62.9% of their MATERIALS AND METHODS From January, 1974 to June, 1985, 20 patients with PHC were admitted to the Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan. Twelve were males and eight were females, and their ages ranged from 8 months to 16 years.
Hepatocellular Carcinoma in an Infant due to Hepatitis B Virus Vertical Transmission
2008
Hepatocellular carcinoma (HCC) is one of the common tumors in the world. The incidence of HCC generally increases with age in all population but there is a tendency of decreasing incidence in the elderly and it is very rare in children. This is a case report of HCC in a 9-month-old boy, who was admitted to the hospital with palpable abdominal mass in the right upper quadrant. Imaging modality by ultrasonography could not adequately demonstrate definite findings demonstrating that the tumor was derived from liver, and the diagnosis was neuroblastoma. Intra-operatively, the tumor mass appeared to be derived from the surface of the posterior edge of the liver, so it was a pedunculated tumor. The histopathological examination revealed a pedunculatedhepatocellular carcinoma grade 3. The Victorian blue staining and immunohistochemical staining were done afterward, which showed HBsAg positive result as found in non-tumor lesion as well as inneoplastic lesion of liver tissue.
Journal of Medical Virology, 1987
Integrated hepatitis B virus (HBV) DNA sequences were found in neoplastic liver tissue of a hepatitis B surface antigen (HBsAg)-negative child who had previously suffered from HBsAg-positive chronic active hepatitis and was anti-HBs and antihepatitis B core (HBc) positive at the time of tumor development. Reintegration pattern was consistent with the presence of a single integration site of the HBV genome into cellular DNA, and clonal proliferation of such infected cells. A normal liver, tested in the same experiment with the same amount of total DNA, was negative for viral DNA sequences.
Journal of …, 2004
Background/Aims: Familial clustering of hepatitis B virus (HBV) infection is related to perinatal transmission, and is the main cause of familial-type hepatocellular carcinoma (HCC). The route of HBV transmission differs between the children and siblings of patients with HCC. This study examined the differences in HBV carrier rates and HCC-related mortality between two generations in HCC families. Methods: From 1992 to 1997, relatives of individuals with HCC were screened prospectively with ultrasonography, alpha-fetoprotein, liver biochemistry tests and viral markers. Total HCC-related deaths during a 9-year period were compared between the generations of index patients and their children. Results: The study included a total of 13 676 relatives in two generations. More HCC-related deaths occurred in the index patient generation than in the child generation. Furthermore, children of female index patients had higher rates of liver cancer related mortality than children of male index patients. The same was true when the analysis was limited to male HBV carriers. The prevalence of HBsAg in the offspring of HBsAg positive mothers was 66% in the child generation and 72% in the index patient generation. These high prevalences indicated high maternal HBV replication status. Conclusions: Perinatal transmission and maternal viral load are important risk factors in hepatocarcinogenesis.
Transplant International, 1993
Abstract. We report two cases of early primary hepatocellular carcinoma (PHC) in children, after probable maternal transmission of hepatitis B, that were treated with orthotopic liver transplantation (OLT). Both children were 8.5 years old and had elevated levels of serum alpha-feto-protein. The diagnosis of PHC was made at 8 years and confirmed histologically. Serum hepatitis B surface antigen (HBs Ag) was detected in the mothers and suggested vertical transmission. An attempt at complete liver tumor resection failed, leading to OLT. In order to prevent recurrence of the hepatitis B virus (HBV) infection, hepatitis B immunoprophylaxis was used. Two years after OLT, one child presented with recurrent HBV infection. No tumor recurrence was observed at follow-up in either of the patients. From these two cases we conclude that (1) HBV infection may play an important causal role in PHC in children, with an even shorter incubation period than that in adults; (2) close follow-up is needed for children who are HBs Ag-positive carriers; and (3) liver transplantation should be proposed early after the diagnosis of PHC, when tumor resection is not feasible.
A Study on the Relationship of Hepatitis B Virus with Hepatocellular Carcinoma
IOSR Journal of Pharmacy and Biological Sciences, 2014
Hepatitis B virus (HBV) has infected approximately 2 billion peo ple worldwide of which more than 350 million are chronically infected life threatening liver disease. This is a study on the relationship of hepatitis B surface antigen (HBsAg) with hepatocellular carcinoma in patients visiting National hospital, Abuja, State house clinic, Abuja and Federal Medical Centre, Keffi, was carried out in 50 liver tissue samples using histochemical reaction of orcein shikata and Haematoxylin and eosin (H and B) staining techniques. Of the 50 samples collected 20 were from National hospital, Abuja, 10 from State house clinic and 20 were from Federal medical centre, Keffi. Sixteen (32%) were diagnosed hepatocellular carcinoma, 10 (20%) liver cirrhosis, 10 (20%) liver hyperplasia and 14 (28%) chronic hepatitis. Out of the 16 hepatocellular carcinoma, 12 (75%) were positive for HBsAg (25%) were negative. For 10liver cirrhosis 7 (30%) were negative. The rest were 8 (80%) positive for hyperplasia out of the 10 samples and all the 14 (100%) cases of chronic hepatitis were positive for HBsAg. Generally, of the 50 samples investigated, 41 (82%) were positive for HBsAg while 9 (18%) were negative. This shows a positive relationship on the pattern of HBsAg amongst the liver diseases under study, and of the two staining techniques employed, orcein shikata gave a better result with ease in recognition and quick screening.
Frontiers in Oncology, 2020
BackgroundHepatocellular carcinoma (HCC) is a rare hepatic malignancy in children. Hepatitis B virus (HBV) infection is a key predisposing factor in endemic regions but its impact on outcome has not been studied. We aim to evaluate the prognostic implication of HBV seropositivity and role of cancer surveillance in children with HCC from East Asian populations with national HBV vaccination.MethodsReview of population-based databases for patients (< 18 years old) diagnosed with HCC from 1993 to 2017 in two Southeast Asian regions with universal HBV vaccination (instituted since 1988 and 1987 in Hong Kong and Singapore, respectively).ResultsThirty-nine patients were identified (Hong Kong, 28; Singapore, 11). Thirty were male; median age at diagnosis was 10.8 years (range, 0.98–16.6). Abdominal pain was the commonest presentation while five patients were diagnosed through surveillance for underlying condition. Alpha-fetoprotein was raised in 36 patients (mean, 500,598 ng/ml). Ninetee...