A combined ″omics″ approach identifies NMI as a novel cytokine-induced regulator of IRE1α and JNK in pancreatic beta cells (original) (raw)
A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells
Flora Brozzi
Journal of Biological Chemistry, 2014
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ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
Décio Eizirik
Upsala Journal of Medical Sciences, 2016
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Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
Décio Eizirik
Frontiers in Endocrinology, 2020
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Proteomics Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells: New Insights into the Pathways Involved
Liliane Schoofs
Molecular & Cellular Proteomics, 2007
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Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
Alessandra Cardozo
Diabetologia, 2012
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Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes
Décio Eizirik
bioRxiv (Cold Spring Harbor Laboratory), 2023
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Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells
Décio Eizirik
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Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes
Bryan O'Sullivan-Murphy
Diabetologia, 2013
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Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
Massimo Pietropaolo
Journal of Theoretical Biology, 2014
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Mild Endoplasmic Reticulum Stress Augments the Proinflammatory Effect of IL-1β in Pancreatic Rat β-Cells via the IRE1α/XBP1s Pathway
Décio Eizirik
Endocrinology, 2012
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Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
M. Kruhoffer
Diabetes, 2003
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Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells
Décio Eizirik
Journal of Biological Chemistry, 2016
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
Maria Alvelos
Nature Communications
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USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis
Décio Eizirik
Cell death & disease, 2012
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An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes
Carl Langefeld
Endocrinology, 2015
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IL1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa2 cells
gaurav verma
Apoptosis, 2010
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Identification of Key β Cell Gene Signaling Pathways Involved in Type 1 Diabetes
Nikolai Petrovsky
Annals of the New York Academy of Sciences, 2004
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Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis
Meng Li
Cell Death and Differentiation, 2009
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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs
Alessandra Cardozo
Diabetologia, 2007
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Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
Décio Eizirik
Arquivos Brasileiros de Endocrinologia & Metabologia, 2008
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Massive parallel gene expression profiling of RINm5F pancreatic islet ?-cells stimulated with interleukin-1?
Morten Svenson
APMIS, 2000
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IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells
Daniel Schorderet
Journal of Biological Chemistry, 2000
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Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells
Décio Eizirik
Diabetes, 2005
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Suppression of Type 1 diabetes by targeting nuclear import of proinflammatory transcription factors
Jacek Hawiger
Diabetes
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The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
Julie Nguyen
PLOS Biology, 2015
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Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
Alessandra Cardozo
Journal of Molecular Endocrinology, 2016
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High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells
Panagiotis Venieratos
Cellular Signalling, 2010
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Dual role of interferon-γ signalling pathway in sensitivity of pancreatic beta cells to immune destruction
Décio Eizirik
Diabetologia, 2001
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Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays
Alessandra Cardozo
Diabetes, 2001
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