original ) (raw )A combined ″omics″ approach identifies NMI as a novel cytokine-induced regulator of IRE1α and JNK in pancreatic beta cells
Flora Brozzi
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IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells
Daniel Schorderet
Journal of Biological Chemistry, 2000
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The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro
Décio Eizirik
Diabetologia, 2015
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Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
M. Kruhoffer
Diabetes, 2003
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ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
Décio Eizirik
Upsala Journal of Medical Sciences, 2016
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The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines
Christophe Bonny
Cytokine, 2003
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Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
Décio Eizirik
Frontiers in Endocrinology, 2020
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Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells
Décio Eizirik
Journal of Biological Chemistry, 2016
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Dual role of interferon-γ signalling pathway in sensitivity of pancreatic beta cells to immune destruction
Décio Eizirik
Diabetologia, 2001
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Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays
Alessandra Cardozo
Diabetes, 2001
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IL1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa2 cells
gaurav verma
Apoptosis, 2010
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Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes
Anne Jörns
Diabetes, 2005
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Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells
Alain Chariot
FEBS Letters, 2012
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IL-1β, IFN-γ and TNF-α increase vulnerability of pancreatic beta cells to autoimmune destruction
Beate Haertel
Journal of Autoimmunity, 2003
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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
Nils Billestrup
Diabetologia, 2005
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The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells
Christophe Bonny
Diabetes, 2000
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Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
Décio Eizirik
Arquivos Brasileiros de Endocrinologia & Metabologia, 2008
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Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells
Décio Eizirik
Diabetes, 2005
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Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH2-Terminal Kinase Signaling
M. Casteele
Diabetes, 2003
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Identification of Key β Cell Gene Signaling Pathways Involved in Type 1 Diabetes
Nikolai Petrovsky
Annals of the New York Academy of Sciences, 2004
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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression
Nils Billestrup
Journal of Diabetes Research, 2016
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Dominant Negative MyD88 Proteins Inhibit Interleukin-1β/Interferon-γ-mediated Induction of Nuclear Factor κB-dependent Nitrite Production and Apoptosis in β Cells
Sandra Cottet
Journal of Biological Chemistry, 2000
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Beta-Cell Apoptosis and Defense Mechanisms: Lessons from Type 1 Diabetes
Décio Eizirik
Diabetes, 2001
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Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis
Meng Li
Cell Death and Differentiation, 2009
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Long-Term IKK2/NF-κB Signaling in Pancreatic β-Cells Induces Immune-Mediated Diabetes
Heba Salem
Diabetes, 2013
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Dominant Negative MyD88 Proteins Inhibit Interleukin-1beta /Interferon-gamma -mediated Induction of Nuclear Factor kappa B-dependent Nitrite Production and Apoptosis in beta Cells
Emanuela Felley-Bosco
Journal of Biological Chemistry, 2000
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Proteomics Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells: New Insights into the Pathways Involved
Liliane Schoofs
Molecular & Cellular Proteomics, 2007
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Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells
Alain Chariot
Febs Letters, 2012
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A biphasic role of nuclear transcription factor (NF)-κB in the islet β-cell apoptosis induced by interleukin (IL)-1β
Antonio Graziano
Journal of Cellular Physiology, 2005
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A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells
Alessandra Cardozo
Journal of Biological Chemistry, 2001
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