Absence of an association between serum uric acid and mortality from cardiovascular disease: NIPPON DATA 80, 1980–1994 (original) (raw)
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Association between serum uric acid and some cardiovascular risk factors in a Chinese population
Postgraduate Medical Journal, 1994
The association between serum uric acid concentration and some cardiovascular risk factors was examined in a working Hong Kong Chinese population (mean age 38 years), consisting of 910 men and 603 women. There was no significant age-related rise in serum uric acid concentration. Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic
Acta Cardiologica, 2001
, ******* see acknowledgments for the composition of the group. Objective-The Gubbio Study is an Italian population study measuring risk factors for and incidence of major cardiovascular diseases.This analysis investigates the association of serum uric acid with the incidence of coronary and cardiovascular events. Methods-A population sample of 2469 men and women aged 35-74 years, free from major cardiovascular diseases and in whom serum uric acid was measured in 1983 along with other standard risk factors, were followed up for 6 years and the incidence of coronary heart disease (CHD) and all cardiovascular atherosclerotic (CVD) events, both fatal and non-fatal, was computed. Proportional hazards models were used for the prediction of these events. Results-In six years 61 CHD hard criteria, 109 CHD any criterion and 149 CVD events were recorded. Age-adjusted rates per 1000 of the 3 event categories were computed in sex-specific quintiles (Q) of serum uric acid with 428 ± 76 (Q 5) and 198 ± 42 (Q 1) µmol/l, respectively. Although higher rates were seen in Q 5 as compared to Q 1 for all three first event categories considered (relative risks 6.2, 3.6 and 3.7, respectively), a statistically significant trend was seen only for CVD all criteria (t = 3.63, p < 0.036). These trends were borderline significant for CHD any criterion (t = 2.92, p < 0.06) and not significant for CHD hard criteria (t = 2.23, p < 0.11). In multivariate models, adjusted for 8 other risk factors, serum uric acid showed a statistically significant contribution to predict CVD incidence [relative risk (RR) for 92 µmol/l difference of 1.24 with 95% confidence intervals (CI) 1.05-1.45], whereas the statistical contribution to predict CHD any criterion (RR = 1.19 with CI 0.98-1.45) and CHD hard criteria (RR = 1.20 with CI 0.93-1.55) was not significant. Diuretic treatment and blood urea, as further confounders, were positively and significantly related to event incidence (RR ranging from 1.21 to 2.00) but serum uric acid maintained its independent and statistically significant role in the prediction of CVD events (RR = 1.18 with CI 1.00-1.39). Presence of specific treatments to lower serum uric acid levels (in 1.13% of the population), tested as final confounders, was not statistically contributory. Conclusions-Increased serum uric acid levels are independently and significantly associated with risk of CVD events in the 6-year follow-up of the Gubbio Study. Longer follow-up is needed before the contributory role of serum uric acid can be properly assessed to explain CHD incidence.
The association between serum uric acid concentration and some cardiovascular risk factors was examined in a working Hong Kong Chinese population (mean age 38 years), consisting of910 men and 603 women. There was no significant age-related rise in serum uric acid concentration. Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic and diastolic blood pressure, urea, creatinine, protein, glucose (fasting and 2 hours after 75 g oral glucose load), 2 hour insulin, triglycerides, and apolipoprotein B in men. Similar, but fewer, associations were seen in women, with the addition of a positive association with age. In both sexes, serum uric acid was negatively associated with high-density lipoprotein cholesterol. These findings complement the well-known clinical association between gout and cardiovascular and metabolic diseases, such as hypertension, hyperlipidaemia and diabetes mellitus, and suggest that serum uric acid may be a marker for the presence of an adverse cardiovascular risk factor profile.
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality
Rheumatology (Oxford, England), 2013
To assess the associations between serum uric acid (SUA) level and mortality. The study included 354 110 subjects without a history of gout and whose SUA levels were tested at Chang Gung Memorial Hospital in Taiwan. Cox regression models were used to estimate hazard ratios and 95% CIs for mortality in six predefined SUA strata (≤0.17, 0.18-0.29, 0.30-0.41, 0.42-0.53, 0.54-0.65 and ≥0.66 mmol/l), after adjusting for age, sex, SUA stratum, estimated glomerular filtration rate, fasting glucose, total cholesterol and history of hypertension, diabetes mellitus, coronary heart disease, stroke, heart failure or chronic kidney disease. There were 33 562 all-cause deaths during the study period. Crude all-cause mortality rates across the SUA strata were 52.5, 19.7, 17.4, 20.0, 28.0 and 41.1 deaths per 1000 person-years. Using the stratum 3 of SUA as a reference, the age- and sex-adjusted hazard ratios (95% CIs) across SUA strata were 2.79 (2.62, 2.96), 1.32 (1.28, 1.36), 1.00, 1.10 (1.07, 1....
Serum uric acid levels and its association with cardiovascular risk factors
Iranian Journal of …, 2009
Background: Although the issue of hyperuricemia as a risk factor for cardiovascular diseases (CVD) has been disputed, several studies have shown an association between hyperuricemia and several CVD risk factors. The aim of this study was to assess distribution of uric acid level in Yazd City, center of Iran, and its association with CVD risk factors. Methods: From autumn 2004 to summer 2005, 2000 urban population of Yazd City, aging 20-74 years via clustering random sampling were enrolled in this cross sectional study. Results: Serum uric acid level, systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist/hip ratio were significantly higher in men than in women (P< 0.001),moreover, total cholesterol, HDL cholesterol and body mass index (BMI) were significantly higher in women (P< 0.001). The prevalence of hyperuricemia and metabolic syndrome in men and women was (17.9%, 11.25% P= 0.001) and (11.87%, 19.32% P= 0.01), respectively. Hyperuricemia was more prevalent in metabolic syndrome and ischemic heart disease independent of age and sex. Conclusion: Significant correlations were found between serum uric acid and several components of the metabolic syndrome. Weight, waist circumstance, triglyceride level and DBP, were the major determinants of the variations in serum uric acid levels .This could be attributed to the insulin resistance status .
2008
6 and the VHM&PP Study Group BACKGROUND: The role of serum uric acid (SUA) as an independent risk factor for cardiovascular disease (CVD) remains controversial, and little is known about its prognostic importance for mortality from congestive heart failure (CHF) and stroke. Few large-scale epidemiologic studies with sufficient follow-up have addressed the association of SUA and CVD mortality in apparently healthy men across a wide age range.
Pitfalls in the evaluation of uric acid as a risk factor for vascular disease
Open Clinical Chemistry Journal, 2010
The association between serum uric acid (SUA) levels and the risk for vascular disease is controversial. Several studies in the general population suggested that elevated SUA levels are independently related to increased vascular morbidity and mortality. However, in other studies this relationship was not significant when other vascular risk factors were considered. Some evidence also suggests that uric acid might be implicated in the development of hypertension, renal disease and insulin resistance. We review the epidemiological data on the relationship between SUA levels and vascular disease and summarize the potential adverse vascular effects of uric acid. We also discuss the associations of SUA levels with established vascular risk factors and the potential benefits of lowering SUA concentration. It is unclear whether uric acid is a causal risk factor for vascular disease. Until more conclusive data are available, patients with elevated SUA levels should be evaluated for the presence of more established risk factors (including type 2 diabetes mellitus, metabolic syndrome and chronic kidney disease) and treatment should be targeted against these factors.
The serum uric acid and related cardiovascular risk factors in south Taiwan
The Southeast Asian journal of tropical medicine and public health, 2005
Hyperuricemia has been shown to be related to cardiovascular morbidity and mortality. Uric acid is a metabolic product synthesized from nucleic acids, amino acids and the Krebs cycle, reflecting a multiple metabolic associations in humans. The relation between uric acid and various cardiovascular metabolic parameters in Asians has rarely been reported on. In this study, we report the relationship between uric acid and various cardiovascular risk factors in 1,027 healthy Taiwanese adults living in Alien, an agricultural town in subtropical South Taiwan. Serum uric acid levels increased in proportion to age in women, but not in men. There were age and gender-specific correlations between uric acid and various cardiovascular metabolic parameters. Triglycerides and creatinine levels were two independent factors predicting serum uric acid levels in men, while only creatinine predicted uric acid levels in women of all age groups. Processes that influence the metabolism of uric acid and it...