Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells (original) (raw)

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction

Mark Boothby

2013

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The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

Thomas Kolbe

Immunity, 2008

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Convergence of the Mammalian Target of Rapamycin Complex 1-and Glycogen Synthase Kinase 3-�����Signaling Pathways Regulates the Innate Inflammatory Response

Huizhi Wang

2011

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Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

Bali Pulendran

Nature Immunology, 2008

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The mTOR pathway and integrating immune regulation

Stephen Cobbold

Immunology, 2013

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Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-β–Signaling Pathways Regulates the Innate Inflammatory Response

Ruqiang Liang

The Journal of Immunology, 2011

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Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression

Alyson Baker

Molecular Immunology, 2009

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mTORC2 combats cellular stress and potentiates immunity during viral infection

Tejabhiram Yadavalli

2020

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mTOR signaling mediates ILC3-driven immunopathology

Annick Peter

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Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

Diane Fingar

Journal of Biological Chemistry, 2010

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Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

Morris Birnbaum

Journal of Biological Chemistry, 2013

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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

vivek panwar

Signal Transduction and Targeted Therapy

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Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner

Valeria Poli

Cellular Signalling, 2016

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Rapamycin Blocks IL-2-Driven T Cell Cycle Progression While Preserving T Cell Survival

juana gonzalez

Blood Cells, Molecules, and Diseases, 2001

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Mammalian target of rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes

Denis Kinane

Molecular Immunology, 2010

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The emerging role of microRNA in regulating the mTOR signaling pathway in immune and inflammatory responses

davoud rostamzadeh

Immunology & Cell Biology, 2021

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Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Simone Schoenwaelder

Nature Communications, 2014

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Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

Edith Hessel

Scientific Reports, 2019

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mTORC1-S6K Activation by Endotoxin Contributes to Cytokine Up-Regulation and Early Lethality in Animals

Anna Wilhelmson

PLoS ONE, 2010

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Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease–antiprotease system by the mTOR inhibitor rapamycin

Bashier Osman

Biochemical Pharmacology, 2011

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Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV+ persons reverses the decrease in TLR-4-mediated TNF-α release through prolongation of MAPK pathway activation

Souvenir Tachado

Journal of immunology (Baltimore, Md. : 1950), 2011

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A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

PAUL ZAREK

The Journal of Immunology, 2007

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TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses

María-paz Marzolo

Cell reports, 2018

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mTOR Regulation of Lymphoid Cells in Immunity to Pathogens

Rachael Keating

Frontiers in Immunology, 2016

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The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists

Tammy Barnes

The EMBO journal, 2018

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Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

Frank Essmann

Cell Cycle, 2013

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mTOR Signaling pathway as a master regulator of memory CD8+ T‐cells, Th17, and NK cells development and their functional properties

davoud rostamzadeh

Journal of Cellular Physiology, 2019

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mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

reza abbasi

Frontiers in Immunology, 2022

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The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

Dr Abderrahman Hachani

Nature Immunology, 2013

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TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells

Mariya Yurchenko

Biomedicines

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Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF- B Activation in Macrophages

Anja Sterner-Kock

Molecular and Cellular Biology, 2010

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mTOR: A Cellular Regulator Interface in Health and Disease

Harald Platta

Cells, 2019

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RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

Kimberly Burns

Nature Immunology, 2004

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mTOR signaling and transcriptional regulation in T lymphocytes

Hongbo Zeng

Transcription, 2014

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