Effects of vitamins C and D in type 2 diabetes mellitus (original) (raw)

Vitamin D and diabetes: the odd couple

Trends in Endocrinology & Metabolism, 2013

The beneficial effects of vitamin D supplementation for a number of health-related issues, including the prevention of diabetes, are a topic of intense discussion. Data from epidemiological studies suggest a correlation between vitamin D deficiency and higher prevalence of both type 1-and type 2-diabetes. In animal models, vitamin D deficiency predisposes to diabetes, whereas vitamin D supplementation prevents disease. Still, welldesigned clinical intervention studies are lacking. Here, we discuss evidence available on a role for vitamin D in diabetes and propose that vitamin D deficiency should be avoided especially in all at-risk people. This should be possible by implementing global guidelines and by focusing on daily dietary supplementation with small doses of vitamin D.

Vitamin D deficiency and its relationship with Type II Diabetes Mellitus (Atena Editora)

Vitamin D deficiency and its relationship with Type II Diabetes Mellitus (Atena Editora), 2023

Hypovitaminosis D exceeds 50% of the Brazilian population, causing major implications for public health in the country. Low vitamin D levels are associated with worse glycemic control. Therefore, the aim of this study is to review the literature on the effect of vitamin D on glycemic control. It has been observed that a low concentration of vitamin D is associated with a decrease in both production and sensitivity to insulin. In patients with type II diabetes, there is a high prevalence of hypovitaminosis D. In this sense, studies with diabetics who underwent vitamin D supplementation still show contradictory data on the effectiveness of supplementation in glycemic control. Thus, it is of paramount importance to carry out research in the area for a reliable result that can cause a direct response in the population.

Vitamin D and Diabetes Mellitus: A Review

Vitamin D deficiency and Diabetes are both disorders of high prevalence in the world. Currently, evidences suggest a possible correlation of low levels of vitamin D with the diagnosis of Diabetes Mellitus. Hypovitaminosis D could be associated with insulin resistance and Diabetes Mellitus, which would in part explain mechanisms involved in the pathogenesis of Diabetes. The aim of this work is to discuss the association between Vitamin D and Diabetes, questioning if vitamin D can prevent the settlement of diabetes or slow down its clinical evolution, and improve the pancreatic function, thus providing a better glycaemic control.

Vitamin D and diabetes mellitus: an update 2013

Arquivos Brasileiros de Endocrinologia & Metabologia, 2014

Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH) 2 D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases. Arq Bras Endocrinol Metab. 2014;58(1):1-8 A deficiência de vitamina D e o diabetes melito são enfermidades comuns na população e são altamente prevalentes em todas as raças, idades, regiões geográficas e situação socioeconômica. Estudos epidemiológicos mostram uma associação entre hipovitaminose D com o aumento do risco de doenças crônicas, tais como câncer, doença cardiovascular, diabetes melito do tipo 2 e doenças autoimunes como a esclerose múltipla e o diabetes mellitus do tipo 1. A identificação de receptores da 1,25(OH) 2 D e da expressão da 1 α-hidroxilase nas células betapancreáticas, em células do sistema imunológico e em uma variedade de células do organismo além do tecido ósseo, suporta o papel da vitamina D na patogênese do diabetes tipo 2 e do tipo 1. Esta revisão apresenta e discute o conceito de deficiência de vitamina D, sua prevalência e seu papel na patogênese e no risco de desenvolvimento do diabetes melito e doenças cardiovasculares. Arq Bras Endocrinol Metab. 2014;58(1):1-8 Descritores Vitamina D; diabetes melito; patogênese

Vitamin D and Diabetes: Let the Sunshine In

The Diabetes Educator, 2008

Diabetes is a leading cause of cardiovascular disease. Persons with diabetes are at greater risk for early cardiac mortality, and for repeat events if they survive their first cardiac event. Recently, low serum concentrations of vitamin D have been associated with increased risk for cardiac events. Evidence indicates that persons with diabetes have lower serum concentrations of vitamin D. In addition, persons at risk for diabetes or metabolic syndrome have inadequate serum concentrations of vitamin D. This review will assess the evidence relative to the impact of vitamin D in the development of diabetes, metabolic syndrome, and diabetes complications. Studies that address vitamin D and its impact on metabolic outcomes as well as possible mechanisms of action are provided. Finally, the assessment and suggested treatment for vitamin D deficiency is addressed. Effective detection and treatment of inadequate vitamin D concentrations in persons with diabetes or those at risk for diabetes may be an easy and cost-effective therapy which could improve their long-term health outcomes as well as their quality of life.

Vitamin D Deficiency and Type 2 Diabetes Mellitus

2014

Vitamin D has skeletal as well as non-skeletal effects including those on the endocrine system. Diabetes Mellitus, a leading cause of morbidity and mortality, has recently been linked to vitamin D status. It has been suggested that vitamin D deficiency is one of the modifiable risk factors for diabetes. We therefore designed this study to look at the relationship between vitamin D levels and diabetes control in type 2 South Asian diabetics from Pakistan. The objective of the study was to determine if correcting vitamin D deficiency improves diabetes control in type 2 diabetics. This analytical cross-sectional study, with prospective follow-up, included 200 subjects with type 2 diabetes (age range 27-76 years), who were deficient in vitamin D. 100 of these were treated with vitamin D and were assigned to the study group, while the rest did not receive treatment with vitamin D and so were placed in the control group. The subjects had their history taken and underwent clinical examinat...

New insights on the role of vitamin D in type 2 diabetes mellitus: Review Article

Abstract: Background: Type 2 diabetes mellitus (T2DM) and vitamin D deficiency are both disorders of high prevalence in the world. Evidence supports an association between low vitamin D levels and risk for T2DM, and its complications. There remains insufficient evidence to suggest whether treatment of low vitamin D can prevent or improve T2DM. Aim: this review will focus on the current understanding of the role of vitamin D in the pathogenesis of T2DM, and questioning if vitamin D supplementation can improve the pancreatic function, thus providing a better glycemic control or slow down its complications. Conclusion and recommendation: deficient vitamin D levels increases the risk of developing T2DM. This finding highlights the need for conducting large-scale health screening to identify those at risk of DM using vitamin D blood level assessment. However, more studies are required to ascertain the effect of vitamin D supplementation in T2DM patients.

VITAMIN D: A POTENTIAL HELPER IN THE FIGHT AGAINST DIABETES MELLITUS

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2021

Vitamin D is the most powerful vitamin, which is the only vitamin that synthesized in our body. The most Vitamin D deficiency disease are Ricket, osteomalacia, osteoporosis, etc. Now a day research study has shown that vitamin D deficit concentration may play important role in the development of Diabetes Mellitus. Vitamin D work on insulin functions by stimulating the beta cell activity. It improves the insulin receptors and glucose transport in to the cell. The deficiency amount of vitamin D intake may lead to the type-II diabetes mellitus. Vitamin D deficiency also led to an increase the level of parathyroid hormone (PTH), which is associated with the insulin resistance. The diet with Vitamin D supplementation reducing insulin resistance and preventing type 2 diabetes mellitus. The purpose of this report is to review the effects of vitamin D on diabetes mellitus.

The Association Between Deficiency of Vitamin D and Diabetes Mellitus Type 2 (DMT2)

Cureus, 2022

Background The impact of vitamin D deficiency on the incidence of various diseases and its relationship with the progression of diabetes mellitus type 2 (DMT2) is still controversial. The present study evaluated the incidence of vitamin D deficiency in patients with DMT2. Methodology A cross-sectional study was conducted in a tertiary care hospital, Sindh, Pakistan from October 2020 to September 2021. A total of 525 patients of DMT2 were recruited. Another 525 patients acted as healthy controls. In patients with DMT2, blood samples were taken in the morning to measure vitamin D levels. All socio-demographic and clinical data were documented in a predefined pro forma. The association between the incidence of DMT2 and hypovitaminosis was explored. Results The mean age of the patients was 50 ± 5.5 years. There were 100 (54.1%) male and 85 (45.9%) female patients. The mean duration of diabetes of the patients was 6.8 ± 2.4 years. The mean serum 25-hydroxy vitamin D level was 22.3 ±10.4 ng/ml. In the case group, the majority of the patients had vitamin D deficiency i.e. 54.1%, while only 25.9% of controls had hypovitaminosis. Vitamin D deficiency was significantly correlated with the occurrence of DMT2 (p<0.0001). Conclusion The current study indicates that patients with diabetes mellitus type 2 (DMT2) more frequently suffer from vitamin D deficiency. Those patients with vitamin D deficiency and DMT2 can benefit from vitamin D replenishment. This may help improve glycemic control in these patients. This study served as a catalyst for future studies where the relationship between hypovitaminosis and insulin resistance can be thoroughly explored.

Vitamin D and diabetes mellitus: Causal or casual association?

Reviews in Endocrine and Metabolic Disorders, 2017

The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell function. Vitamin D status or elements involved in its activation or transport may also be involved in the development of type 1 diabetes mellitus through immunomodulatory role. Based on these observations a potential association between vitamin D and diabetes has been hypothesized. In this review we discuss up to date evidence linking vitamin D with the development of diabetes. Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. We also address the potential role of vitamin D deficiency in the development of macro-and microvascular complications in diabetes. Finally, we provide recommendation for Vitamin D therapy in diabetes in view of current evidence and highlight areas for potential future research in this area.