Interaction of 5-fluoro-4-thio-2′-deoxyuridine 5′-phosphate with mammalian tumour thymidylate synthase: Role of the pyrimidine N(3)-H dissociation (original) (raw)

Biochemical Pharmacology, 1987

Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2′-deoxyuridine 5′-phosphate

Bioorganic & Medicinal Chemistry Letters, 2000

Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant ehrlich ascites carcinoma cells

Biochemical Pharmacology, 1983

Developments of the fluoropyrimidines as inhibitors of thymidylate synthetase: pharmacologic and clinical aspects

David Machover

Journal of surgical oncology, 1991

Molecular Aspects of the Mechanism of Action of 5-FLUORODEOXYURIDINE

Annals of the New York Academy of Sciences, 1975

Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N4-hydroxy-dCMP

Molecular BioSystems, 2016

The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism

Bioorganic & Medicinal Chemistry Letters, 2010

5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression

B. Otter

Cancer research, 1995

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate

Ernest Villafranca

Journal of Molecular Biology, 1990

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

Zbigniew Zieliński

2006

Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine

Istvan Szinai

Biochemical Pharmacology, 1990

Regulation of the activation of fluorodeoxyuridine by substrate competition and feedback inhibition in 647V cells

Miguel A . Vazquez Padua

Cancer research, 1989

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

E Santis

Biochemistry, 1974

Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of BUMP and 5-fluoro-dUMP

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1996

Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP

Archives of Biochemistry and Biophysics, 2019

Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity

P. Bey

British Journal of Cancer, 1998

Interaction of the 5′-phosphates of the anti-hiv agents, 3′-azido-3′-deoxythymidine and 3′-azido-2′,3′-dideoxyuridine, with thymidylate synthase

Joanna Ciesla

Biochemical and Biophysical Research Communications, 1988

Biochemical Properties of 5-SULFUR-SUBSTITUTED Pyrimidine Nucleosides and Nucleotides

Annals of the New York Academy of Sciences, 1975

Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues

Jay Gerlach

Nucleic Acids Research, 1999

Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives

Neva Besker

Colloids and Surfaces B: Biointerfaces, 2016

Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: models of substituted dUMP pyrimidine ring interacting with thymidylate synthase

Maria Bretner

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

Elisabeth Bloemena

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002