original ) (raw )Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor
Raymond Schinazi
Cancer Chemotherapy and Pharmacology, 2006
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Role of uridine phosphorylase in the anabolism of 5-fluorouracil
Paul J Turek
Biochemical Pharmacology, 1985
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Increased formation of nucleotide derivatives of 5-fluorouridine in hepatoma cells treated with inhibitors of pyrimidine synthesis and D-galactosamine
Axel Holstege
FEBS Letters, 1978
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Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro
Kara Vine
Bioorganic & Medicinal …, 2010
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Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics and in vitro influence on 5-fluorouracil cytotoxicity
Osmar Norberto de Souza
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Antitumor effect of 2'-deoxy-5-fluorouridine conjugates against a murine thymoma and colon carcinoma xenografts
Geoffrey Pietersz
Cancer research, 1992
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5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression
B. Otter
Cancer research, 1995
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Enhancement of 5‐fluorouracil cytotoxicity by human thymidine‐phosphorylase expression in cancer cells: In vitro and In vivo study
André Pèlegrin
International Journal of Cancer, 1999
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Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil
Thomas Spector
Cancer research, 1995
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Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase
B. Otter
Cancer research, 1994
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Tumor-selective Metabolism of 5-Fluoro-2′-deoxycytidine Coadministered with Tetrahydrouridine Compared to 5-Fluorouracil in Mice Bearing Lewis Lung Carcinoma
David Boothman
Cancer Research, 1987
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Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
Amir Moghaddam
British journal of cancer, 1995
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Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil
Bach Ardalan
Cancer research, 1980
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Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response
Philip Schein
Biochemical Pharmacology, 1978
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Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo
Athanassios Iliadis
Molecular cancer therapeutics, 2001
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Interaction of 5-fluoro-4-thio-2′-deoxyuridine 5′-phosphate with mammalian tumour thymidylate synthase: Role of the pyrimidine N(3)-H dissociation
Joanna Ciesla
Biochemical and Biophysical Research Communications, 1987
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Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis
Guilherme Petersen
Investigational new drugs, 2014
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Synergistic effect of 5-fluorouracil and on cell growth and ribonucleic acid synthesis in a human mammary carcinoma
Bach Ardalan
Biochemical Pharmacology, 1981
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5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
Thomas Spector
Proceedings of the National Academy of Sciences, 1993
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Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase
Colin Paul Spears
Proceedings of the National Academy of Sciences, 1979
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Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity
Keizo Takenaga
Cancer Gene Therapy, 2000
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In vitro toxicity of N3-methyl-5′-deoxy-5-fluorouridine, a novel metabolite of doxifluridine: a bioanalytical investigation
Antonella Aresta
Journal of Pharmaceutical and Biomedical Analysis, 1998
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α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil
Thomas Spector
Biochemical Pharmacology, 2000
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Sulfonyl-Containing Nucleoside Phosphotriesters and Phosphoramidates as Novel Anticancer Prodrugs of 5-Fluoro-2‘-deoxyuridine 5‘-Monophosphate (FdUMP)
Yuan Wan Sun
Molecular Pharmaceutics, 2006
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Effect of 3‘-Azido-3’-deoxythymidine on 5-Fluorouracil Metabolism in Human Promyelocyte Leukaemia HL-60 Cells
Thomas Szekeres
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Exploitation of elevated pyrimidine deaminating enzymes for selective chemotherapy
David Boothman
Pharmacology & Therapeutics, 1989
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Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase
Abdalla Hassan
Cancer Gene Therapy, 2003
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Comparison of Bioactivities of 5-Fluoro, 5-Iodo, 5-Iodovinyl, and 5-Fluorovinyl Arabinosyl Uridines against SR-39 TK-Transfected Murine Prostate Cancer Cells
Chi-Shiun Chiang
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008
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A Novel In Vitro Assay to Assess Phosphorylation of 3′-[18F]fluoro-3′-Deoxythymidine
Mohammad Ozair Ansari
Molecular Imaging and Biology, 2011
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