Mutations Activating theYeasteIF-2o Kinase GCN2: Isolation ofAlleles Altering theDomainRelated to Histidyl-tRNA Synthetases (original) (raw)
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases
Belinda Jackson
Molecular and Cellular Biology, 1992
View PDFchevron_right
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
Shuhao Zhu
Molecular and cellular biology, 1995
View PDFchevron_right
The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation
Alan Hinnebusch
The EMBO Journal, 2001
View PDFchevron_right
Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor …
A. Hopper
… and cellular biology, 2000
View PDFchevron_right
Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast
Alan Hinnebusch
Nucleic Acids Research, 2005
View PDFchevron_right
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2
Hongfang Qiu
Molecular and cellular biology, 1997
View PDFchevron_right
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control
Belinda Jackson
Molecular and Cellular Biology, 1991
View PDFchevron_right
Genetic evidence for functional specificity of the yeast GCN2 kinase
Nektarios Tavernarakis
MGG Molecular & General Genetics, 1996
View PDFchevron_right
Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2
Alexander Sobolev
Journal of Biological Chemistry, 1996
View PDFchevron_right
Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo
Mark Ashe
PLOS Genetics, 2015
View PDFchevron_right
Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2
Hongfang Qiu
Genes & Development, 2002
View PDFchevron_right
Gene overexpression reveals alternative mechanisms that induce GCN4 mRNA translation
Nektarios Tavernarakis
Gene, 1996
View PDFchevron_right
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae
Robert Matts
Molecular and Cellular Biology, 1993
View PDFchevron_right
Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
Joseph Nika
2000
View PDFchevron_right
Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain
Alan Hinnebusch
Molecular Cell, 2000
View PDFchevron_right
Snf1 Promotes Phosphorylation of the Subunit of Eukaryotic Translation Initiation Factor 2 by Activating Gcn2 and Inhibiting Phosphatases Glc7 and Sit4
Hongfang Qiu, Vera Cherkasova
Molecular and Cellular Biology, 2010
View PDFchevron_right
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2α phosphorylation and translation of a small upstream open reading …
Maria Hatzoglou
Journal of Biological …, 2002
View PDFchevron_right
Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3
S. Inge-vechtomov
Molecular Biology, 2006
View PDFchevron_right
The molecular aetiology of tRNA synthetase depletion: induction of aGCN4amino acid starvation response despite homeostatic maintenance of charged tRNA levels
Brandon Childers
2019
View PDFchevron_right
Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF
Galina Zhouravleva
View PDFchevron_right
Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast
Dominic Ortiz
Nucleic Acids Research, 2005
View PDFchevron_right
Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression
Belinda Jackson
Molecular and Cellular Biology, 1990
View PDFchevron_right
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3
Mercedes Tamame
Genes & Development, 1995
View PDFchevron_right
5'TRU: Identification and Analysis of Translationally Regulative 5'Untranslated Regions in Amino Acid Starved Yeast Cells
Burkhard Morgenstern
Molecular & Cellular Proteomics, 2011
View PDFchevron_right
Eukaryotic Translation Initiation Factor 4E-Dependent Translation Is Not Essential for Survival of Starved Yeast Cells
Mordechai Choder
Journal of Bacteriology, 2001
View PDFchevron_right
Global translational impacts of the loss of the tRNA modification t6A in yeast
Alvaro Glavic
Microbial Cell, 2016
View PDFchevron_right
Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae
Mercedes Tamame
Genetics, 2011
View PDFchevron_right
[Increased tRNA concentration in yeast containing mutant termination translation factors eRF1 and eRF3]
Galina Zhouravleva
Molekuliarnaia biologiia
View PDFchevron_right
Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals
Isha Singh
Journal of Biological Chemistry, 2014
View PDFchevron_right
Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae
Mercedes Tamame
Genetics, 2011
View PDFchevron_right
Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p
Florian Freimoser
Journal of Biological Chemistry, 2009
View PDFchevron_right
Repression of GCN4 mRNA Translation by Nitrogen Starvation in Saccharomyces cerevisiae
Gerhard Braus
Journal of Biological Chemistry, 2001
View PDFchevron_right
Charcot–Marie–Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response
samantha mendonsa
Nucleic Acids Research, 2021
View PDFchevron_right
The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2
Uttam Rajbhandary
Molecular and Cellular Biology, 1996
View PDFchevron_right
Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation
Graham Pavitt
Molecular and Cellular Biology, 2001
View PDFchevron_right