Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo (original) (raw)
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases
Belinda Jackson
Molecular and Cellular Biology, 1992
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The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation
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The EMBO Journal, 2001
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Mutations Activating theYeasteIF-2o Kinase GCN2: Isolation ofAlleles Altering theDomainRelated to Histidyl-tRNA Synthetases
Alan Hinnebusch
1992
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The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
Shuhao Zhu
Molecular and cellular biology, 1995
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Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2
Hongfang Qiu
Genes & Development, 2002
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Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain
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Molecular Cell, 2000
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Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2
Alexander Sobolev
Journal of Biological Chemistry, 1996
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Genetic evidence for functional specificity of the yeast GCN2 kinase
Nektarios Tavernarakis
MGG Molecular & General Genetics, 1996
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Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor …
A. Hopper
… and cellular biology, 2000
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Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p
Florian Freimoser
Journal of Biological Chemistry, 2009
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Yves Mechulam
Nucleic Acids Research, 2013
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Alan Hinnebusch
Nucleic Acids Research, 2005
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The molecular aetiology of tRNA synthetase depletion: induction of aGCN4amino acid starvation response despite homeostatic maintenance of charged tRNA levels
Brandon Childers
2019
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Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF
Galina Zhouravleva
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Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression
Belinda Jackson
Molecular and Cellular Biology, 1990
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Increased tRNA level in yeast cells with mutant translation termination factors eRF1 and eRF3
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Molecular Biology, 2006
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Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals
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Journal of Biological Chemistry, 2014
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tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast
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Global translational impacts of the loss of the tRNA modification t6A in yeast
Alvaro Glavic
Microbial Cell, 2016
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GCD14p, a Repressor of GCN4 Translation, Cooperates with Gcd10p and Lhp1p in the Maturation of Initiator Methionyl-tRNA in Saccharomyces cerevisiae
Mercedes Tamame
Molecular and Cellular Biology, 1999
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A Network of Hydrophobic Residues Impeding Helix C Rotation Maintains Latency of Kinase Gcn2, Which Phosphorylates the Subunit of Translation Initiation Factor 2
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Molecular and Cellular Biology, 2009
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The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications
LAURA VALENTINA BADILLO JARAMILLO
RNA, 2012
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[Increased tRNA concentration in yeast containing mutant termination translation factors eRF1 and eRF3]
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Molekuliarnaia biologiia
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The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2
Uttam Rajbhandary
Molecular and Cellular Biology, 1996
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Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling
Vicente Olivas Ramirez
PLoS Genetics, 2013
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Fission yeast TORC1 prevents eIF2 phosphorylation in response to nitrogen and amino acids via Gcn2 kinase
Sergio Moreno
Journal of Cell Science, 2012
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tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast
Gabriela Moura
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Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast
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2020
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The highly acidic C-terminal region of the yeast initiation factor subunit 2 α (eIF-2 α) contains casein kinase phosphorylation sites and is essential for maintaining normal regulation of GCN4
Joop van den Heuvel
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
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Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast
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Gene overexpression reveals alternative mechanisms that induce GCN4 mRNA translation
Nektarios Tavernarakis
Gene, 1996
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Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization
George Diallinas
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Lack of tRNA Modification Isopentenyl-A37 Alters mRNA Decoding and Causes Metabolic Deficiencies in Fission Yeast
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Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2
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Molecular and cellular biology, 1997
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Activation of Gcn2 in response to different stresses
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PLOS ONE, 2017
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