IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects (original) (raw)

Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains

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Neurotoxicity of an MPTP Analogue, 2/CH 3 -MPTP, on Monoaminergic Systems in the Mouse Brain

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In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity

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Striatal MPP+Levels do not Necessarily Correlate with Striatal Dopamine Levels after MPTP Treatment in Mice

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Influence of monoamine oxidase inhibitors and a dopamine uptake blocker on the distribution of 11 C-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 11 C-MPTP, in the head of the Rhesus monkey

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Effect of MPTP on Serotonergic Neuronal Systems and Mitochondrial Complex I Activity in the Living Brain: A PET Study on Conscious Rhesus Monkeys

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Neurotoxicity of MPTP and MPP+ in vitro: characterization using specific cell lines

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Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice

Anat Tsur

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Toxic effects of potential environmental neurotoxins related to MPP+ on cultured rat dopaminergic neurons

Simon Efange

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Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP

Rona Ramsay

Life Sciences, 1986

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Electrophysiological and neurochemical correlates of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in the mouse

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Absence of MPTP-Induced Neuronal Death in Mice Lacking the Dopamine Transporter

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Experimental Neurology, 1999

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Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss

Gelareh Alam

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Comparison of the effects of intracerebrally administered MPP+ (1-methyl-4-phenylpyridinium) in three species: microdialysis of dopamine and metabolites in mouse, rat and monkey striatum

Guillermo Alexander

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Continuous MPTP intoxication in the Göttingen minipig results in chronic parkinsonian deficits

Arne Møller

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Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset

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Brain Research, 1991

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Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity

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MPTP-Induced Pallidal Lesions in Rhesus Monkeys

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Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model

Ole Isacson

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Nigral and Striatal Comparative Study of the Neurotoxic Action of 1-Methyl-4-Phenylpyridinium Ion: Involvement of Dopamine Uptake System

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MPP+ toxicity in rat striatal slices: Relationship between non-selective effects and free radical production

Santiago Ambrosio

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MPP(+)-Lesioned Mice: an Experimental Model of Motor, Emotional, Memory/Learning, and Striatal Neurochemical Dysfunctions

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MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study

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The Parkinsonian Neurotoxin 1-Methyl-4-Phenylpyridinium (MPP + ) Mediates Release of l -3,4-Dihydroxyphenylalanine ( l -DOPA) and Inhibition of l -DOPA Decarboxylase in the Rat Striatum: A Microdialysis Study

Glenn Dryhurst

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Prolonged Alterations in Canine Striatal Dopamine Metabolism Following Subtoxic Doses of l-Methyl-4-Phenyl- 1,2,3,6-Tetrahydropyridine (MPTP) and 4'-Amino-MPTP Are Linked to the Persistence of Pyridinium Metabolites

Sanford Markey

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Pramipexole protects against MPTP toxicity in non-human primates

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MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: reference to striatonigral degeneration

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MPTP-Induced Parkinsonism in Minipigs

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