Mechanism of the neurotoxicity of MPTP (original) (raw)

Mechanism of the neurotoxicity of MPTP: An update

Febs Letters, 1990

Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same

Rona Ramsay

Biochemical Journal, 1991

View PDFchevron_right

The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase

Rona Ramsay

Archives of Biochemistry and Biophysics, 1987

View PDFchevron_right

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

Rona Ramsay

Biochemical and Biophysical Research Communications, 1986

View PDFchevron_right

Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Rona Ramsay

Toxicology, 1988

View PDFchevron_right

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine

Ritik Kumar

Life sciences, 1985

View PDFchevron_right

Toxication of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and analogs by monoamine oxidase

Mark S Baird

Biochemical Pharmacology, 1990

View PDFchevron_right

Biochemical Events in the Development of Parkinsonism Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine

Rona Ramsay

Journal of Neurochemistry, 1987

View PDFchevron_right

Inhibition of NADH oxidation by pyridine derivatives

Rona Ramsay

Biochemical and Biophysical Research Communications, 1987

View PDFchevron_right

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

Rona Ramsay

Biochemical and Biophysical Research Communications, 1986

View PDFchevron_right

Analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as monoamine oxidase substrates: a second ring is not necessary

Jane Willoughby

Neuroscience Letters, 1987

View PDFchevron_right

Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

James Adams

Biochemical Pharmacology, 1991

View PDFchevron_right

Neurotoxicity of an MPTP Analogue, 2/CH 3 -MPTP, on Monoaminergic Systems in the Mouse Brain

Mukesh Gupta

Annals of the New York Academy of Sciences, 1992

View PDFchevron_right

The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety: The parkinsonian toxin MPTP

Muhammad Akram

Journal of Neurochemistry, 2001

View PDFchevron_right

Electrophysiological and neurochemical correlates of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in the mouse

Ivan Mefford

Naunyn-Schmiedeberg's Archives of Pharmacology, 1985

View PDFchevron_right

The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety

Muhammad Akram Phd

Journal of Neurochemistry, 2001

View PDFchevron_right

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria

Rona Ramsay

The Journal of Biological Chemistry, 1986

View PDFchevron_right

Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice

Anat Tsur

Brain Research, 1986

View PDFchevron_right

Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Keith Tipton

Biochemical Journal, 1986

View PDFchevron_right

Influence of monoamine oxidase inhibitors and a dopamine uptake blocker on the distribution of 11 C-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 11 C-MPTP, in the head of the Rhesus monkey

Bengt Långström

Acta Neurologica Scandinavica, 1986

View PDFchevron_right

Dopaminergic Neurotoxicity In Vivo and Inhibition of Mitochondrial Respiration In Vitro by Possible Endogenous Pyridinium-Like Substances

Charles Hoppel

Journal of Neurochemistry, 1991

View PDFchevron_right

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice

Alan Hazell

Brain Research, 1992

View PDFchevron_right

Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture

Simon Efange

Experimental Neurology, 1990

View PDFchevron_right

Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP

Rona Ramsay

Life sciences, 1986

View PDFchevron_right

In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity

Leonid Kelner

Neurochemistry International, 1985

View PDFchevron_right

MPTP and MPTP analogs induced cell death in cultured rat hepatocytes involving the formation of pyridinium metabolites

yogendra singh

Toxicology and Applied Pharmacology, 1988

View PDFchevron_right

Edward Neafsey

Annals of The New York Academy of Sciences, 1992

View PDFchevron_right

Mechanism of the neurotoxicity of MPTP (original) (raw)

Related papers