Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway (original) (raw)

First-In-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR In Patients With Advanced Cancer

Jorge Gallo, Lixin Han

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PI3K/Akt signalling pathway and cancer

JAVIER CASTRO

Cancer Treatment Reviews, 2004

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The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

Carlos Castañeda

Cancer and Metastasis Reviews, 2010

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The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications

Alexandre Arcaro

Current Genomics, 2007

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Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216

Jinjiang Zhu

Clinical Cancer Research, 2014

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Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

Sandra Gabelli

Biophysical Reviews, 2014

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Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

C. Fumarola

Biochemical Pharmacology, 2014

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain

Anke Klippel

Molecular and cellular biology, 1997

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PIK3CA Cooperates with Other Phosphatidylinositol 3'-Kinase Pathway Mutations to Effect Oncogenic Transformation

David Stokoe

Cancer Research, 2008

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The PKB/AKT Pathway in Cancer

Amancio Carnero

Current Pharmaceutical Design, 2010

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Targeting PI3K in Cancer: Any Good News?

Miriam Martini

Frontiers in Oncology, 2013

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Status of PI3K inhibition and biomarker development in cancer therapeutics

Josep Tabernero

Annals of …, 2010

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Analysis of PI3K pathway components in human cancers

Bashar Saad

Oncology Letters, 2016

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Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases

Alan Henley

Cancer Research, 2007

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Cancer Therapy : Preclinical Antitumor Efficacy of PKI-587 , a Highly Potent Dual PI 3 K / mTOR Kinase Inhibitor

Inder Chaudhary

2011

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Inhibiting PI3K as a therapeutic strategy against cancer

Luis Paz-ares, Amancio Carnero

Clinical and Translational Oncology, 2009

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Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor

Semiramis Ayral-Kaloustian

Clinical Cancer …, 2011

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Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases

Ahmed Abdel-Magid

ACS medicinal chemistry letters, 2017

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Targeting phosphoinositide 3-kinase—Moving towards therapy

Bernd Giese, Vladimir Cmiljanovic

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2008

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3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

Lao Saal

Cancer Research, 2009

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The selective PI3K inhibitor XL147 (SAR245408) inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models

Wendy Abulafia, Paul Keast, Sanh Lam, Charles Marlowe

Molecular cancer therapeutics, 2015

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Oncogenic PI3K deregulates transcription and translation

Peter Vogt

Nature Reviews Cancer, 2005

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Characterization of the Activity of the PI3K/mTOR Inhibitor XL765 (SAR245409) in Tumor Models with Diverse Genetic Alterations Affecting the PI3K Pathway

Xiangnan Du

Molecular Cancer Therapeutics, 2014

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Targeting PI3K/Akt/mTOR Signaling in Cancer

Alessandra Mosca

Frontiers in oncology, 2014

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DEVELOPMENT OF DRUGS TARGETING THE PI3K SIGNALLING PATHWAY IN LEUKAEMIAS AND LYMPHOMAS

Alexandre Arcaro

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PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches

Linda Steelman

Cell Cycle, 2009

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Phosphatidylinositol 3-Kinase Isoforms as Novel Drug Targets

Alexandre Arcaro

Current Drug Targets, 2011

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