Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway (original) (raw)
First-In-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR In Patients With Advanced Cancer
Jorge Gallo, Lixin Han
View PDFchevron_right
PI3K/Akt signalling pathway and cancer
JAVIER CASTRO
Cancer Treatment Reviews, 2004
View PDFchevron_right
The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
Carlos Castañeda
Cancer and Metastasis Reviews, 2010
View PDFchevron_right
The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
Alexandre Arcaro
Current Genomics, 2007
View PDFchevron_right
Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216
Jinjiang Zhu
Clinical Cancer Research, 2014
View PDFchevron_right
Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects
Sandra Gabelli
Biophysical Reviews, 2014
View PDFchevron_right
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
C. Fumarola
Biochemical Pharmacology, 2014
View PDFchevron_right
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
Anke Klippel
Molecular and cellular biology, 1997
View PDFchevron_right
PIK3CA Cooperates with Other Phosphatidylinositol 3'-Kinase Pathway Mutations to Effect Oncogenic Transformation
David Stokoe
Cancer Research, 2008
View PDFchevron_right
The PKB/AKT Pathway in Cancer
Amancio Carnero
Current Pharmaceutical Design, 2010
View PDFchevron_right
Targeting PI3K in Cancer: Any Good News?
Miriam Martini
Frontiers in Oncology, 2013
View PDFchevron_right
Status of PI3K inhibition and biomarker development in cancer therapeutics
Josep Tabernero
Annals of …, 2010
View PDFchevron_right
Analysis of PI3K pathway components in human cancers
Bashar Saad
Oncology Letters, 2016
View PDFchevron_right
Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Alan Henley
Cancer Research, 2007
View PDFchevron_right
Cancer Therapy : Preclinical Antitumor Efficacy of PKI-587 , a Highly Potent Dual PI 3 K / mTOR Kinase Inhibitor
Inder Chaudhary
2011
View PDFchevron_right
Inhibiting PI3K as a therapeutic strategy against cancer
Luis Paz-ares, Amancio Carnero
Clinical and Translational Oncology, 2009
View PDFchevron_right
Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor
Semiramis Ayral-Kaloustian
Clinical Cancer …, 2011
View PDFchevron_right
Potential of PI3Kβ Inhibitors in the Treatment of Cancer and Other Diseases
Ahmed Abdel-Magid
ACS medicinal chemistry letters, 2017
View PDFchevron_right
Targeting phosphoinositide 3-kinase—Moving towards therapy
Bernd Giese, Vladimir Cmiljanovic
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2008
View PDFchevron_right
3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Lao Saal
Cancer Research, 2009
View PDFchevron_right
The selective PI3K inhibitor XL147 (SAR245408) inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models
Wendy Abulafia, Paul Keast, Sanh Lam, Charles Marlowe
Molecular cancer therapeutics, 2015
View PDFchevron_right
Oncogenic PI3K deregulates transcription and translation
Peter Vogt
Nature Reviews Cancer, 2005
View PDFchevron_right
Characterization of the Activity of the PI3K/mTOR Inhibitor XL765 (SAR245409) in Tumor Models with Diverse Genetic Alterations Affecting the PI3K Pathway
Xiangnan Du
Molecular Cancer Therapeutics, 2014
View PDFchevron_right
Targeting PI3K/Akt/mTOR Signaling in Cancer
Alessandra Mosca
Frontiers in oncology, 2014
View PDFchevron_right
DEVELOPMENT OF DRUGS TARGETING THE PI3K SIGNALLING PATHWAY IN LEUKAEMIAS AND LYMPHOMAS
Alexandre Arcaro
View PDFchevron_right
PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches
Linda Steelman
Cell Cycle, 2009
View PDFchevron_right
Phosphatidylinositol 3-Kinase Isoforms as Novel Drug Targets
Alexandre Arcaro
Current Drug Targets, 2011
View PDFchevron_right