Analysis of PI3K pathway components in human cancers (original) (raw)
PI3K/Akt signalling pathway and cancer
JAVIER CASTRO
Cancer Treatment Reviews, 2004
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The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
Alexandre Arcaro
Current Genomics, 2007
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Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection
Joffre Baker
PloS one, 2012
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Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer
Julian Downward
2012
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Targeting PI3K in Cancer: Any Good News?
Miriam Martini
Frontiers in Oncology, 2013
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Mouse Models to Decipher the PI3K Signaling Network in Human Cancer
O. Renner
Current Molecular Medicine, 2009
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PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors
carlos rubio arteaga
Clinical cancer research : an official journal of the American Association for Cancer Research, 2017
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Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Pascal Furet
Future Medicinal Chemistry, 2009
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PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches
Linda Steelman
Cell Cycle, 2009
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Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma
Valter Agosti
PLoS ONE, 2013
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Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness
Aggeliki Tserga
Virchows Archiv, 2016
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The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy
Ahmed Alhaj Ahmed
Cancer Research, 2014
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Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities
Denis Jardim
Cancer
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The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review
Federica Rascio
Cancers
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Supplementary Figures 1 - 6 from Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Ling Huw
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Targeting the PI3K/AKT/mTOR/NFkB Axis in Ovarian Cancer
Neveen Said
Journal of Cellular Immunology, 2020
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Elevated PI3K signaling drives multiple breast cancer subtypes
Sean Egan
Oncotarget, 2011
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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Raju Kucherlapati
Cancer cell, 2017
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Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer
A. Turke
Cancer Research, 2011
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PIK3CA Cooperates with Other Phosphatidylinositol 3'-Kinase Pathway Mutations to Effect Oncogenic Transformation
David Stokoe
Cancer Research, 2008
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Targeting PI3K/Akt/mTOR Signaling in Cancer
Alessandra Mosca
Frontiers in oncology, 2014
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Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects
Catherine Pythoud
Biochemical and Biophysical Research Communications, 2013
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Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Hartmut Koeppen
Clinical Cancer Research, 2012
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Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer
Geoffrey Shapiro
Current Oncology Reports, 2010
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Activation of PI3K Is Associated with Reduced Survival in Renal Cell Carcinoma
Stephan Kruck
Urologia Internationalis, 2008
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Data from Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Ling Huw
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Inhibiting PI3K as a therapeutic strategy against cancer
Luis Paz-ares, Amancio Carnero
Clinical and Translational Oncology, 2009
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AKT-independent PI3-K signaling in cancer – emerging role for SGK3
Richard Pearson
Cancer Management and Research, 2013
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Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours
Alexandre Arcaro
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Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer
Thang Tran Viet
Journal of Surgical Oncology, 2013
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The Essential Role of Phosphoinositide 3-Kinases (PI3Ks) in Regulating Pro-Inflammatory Responses and the Progression of Cancer
Pablo Iribarren
2000
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Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy.
Dawid G Nowak
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3-Phosphoinositide–Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner
Giorgio Seano, Paolo Armando Gagliardi, Francesca Orso, Federico Bussolino
2012
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Detection of PIK3/AKT pathway in Moroccan population with triple negative breast cancer
Basma Bilal
BMC cancer, 2018
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AKT-independent PI3-K signaling in cancer – emerging role for SGK3
Ross Hannan
Cancer Management and Research, 2013
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