Design and synthesis of novel antihypertensive drugs (original) (raw)
Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy
Panagiotis Zoumpoulakis
Journal of Pharmaceutical and Biomedical Analysis, 2003
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Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues
P. Moutevelis-minakakis, Christoforos Kokotos, T. Mavromoustakos, Panagiotis Zoumpoulakis
Bioorganic & Medicinal Chemistry, 2006
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Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*–π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists
John Matsoukas
Bioorganic & Medicinal Chemistry, 2001
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Rational Design and Synthesis of AT1R Antagonists
Andreas G Tzakos
Molecules, 2021
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Structural Insight on the Activity of Type 1 Angiotensin II Peptide Antagonists Using MD Simulations
Hernâni Maia
The Journal of Physical Chemistry B, 2008
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Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors
Andreas G Tzakos
Molecules (Basel, Switzerland), 2015
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Superimposition of potent non-peptide AT1 receptor antagonists with angiotensin II
John Matsoukas
Letters in Peptide Science, 1996
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Structural comparison between type I and type II antagonists: possible implications in the drug design of AT1 antagonists
John Matsoukas
Bioorg Medicinal Chem Letter, 2000
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American Journal of Phytomedicine and Clinical Therapeutics A Quantitative Structure Activity Relationship Approach to Design Angiotensin II Receptor Antagonists as Antihypertensive Agents by Knn-Mfa
Am Jour of Phytomed & Clinical Therapeut
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Design, Synthesis, Structural Studies, Biological Evaluation, and Computational Simulations of Novel Potent AT 1 Angiotensin II Receptor Antagonists Based on the 4-Phenylquinoline Structure
Maurizio Anzini
Journal of Medicinal Chemistry, 2004
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Differences in Backbone Structure between Angiotensin II Agonists and Type I Antagonists
Amal Wahhab
Journal of Medicinal Chemistry, 1995
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Receptor interactions of the position 4 side chains of angiotensin II analogues: Importance of aromatic ring quadrupole
John Matsoukas
Journal of Molecular Recognition, 1994
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Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists
Nasser Ismail
Medicinal Chemistry Research, 2014
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Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships
Fred Nyberg, Nicole Gallo-payet, Ulrika Rosenström, Mathias Hallberg
Bioorganic & Medicinal Chemistry, 2008
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Structural Evolution and Pharmacology of a Novel Series of Triacid Angiotensin II Receptor Antagonists.
Kumiko Takeuchi
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N- and C-terminal structure–activity study of angiotensin II on the angiotensin AT2 receptor
Lenka Rihakova
European Journal of Pharmacology, 1998
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Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes
Tomasz Glinka
Bioorganic & Medicinal Chemistry Letters, 1994
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CHIRAL RECOGNITION OF THE ANGIOTENSIN II (ATI) RECEPTOR BY A HIGHLY POTENT PHENOXYPROLINE OCTANOAMIDE
Kumiko Takeuchi
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Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor
Nilkanth Patel
The Journal of biological chemistry, 2015
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Structure-activity relationships for the carboxy-terminus-truncated analogs of angiotensin II, a new class of angiotensin II antagonists
MARIA TERESA MARTIN PALOMO
Journal of Medicinal Chemistry, 1990
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Antihypertensive Drugs that Act on Renin-Angiotensin System with Emphasis in AT1 Antagonists
T. Mavromoustakos
Mini-Reviews in Medicinal Chemistry, 2001
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The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II
John Matsoukas
Bioorganic & Medicinal Chemistry, 2000
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Biological activity of the novel cyclic angiotensin II analogue [Sar1,Lys3,Glu5]ANG II
John Matsoukas
Letters in Peptide Science, 1996
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The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists
Tomasz Glinka
Bioorganic & Medicinal Chemistry Letters, 1996
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Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT 2 Receptor Affinity
Adolf Gogoll, Mats Larhed, Gunnar Lindeberg, Fred Nyberg
Journal of Medicinal Chemistry, 2005
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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3, 5 side-chain bridges: role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists
Panagiotis Zoumpoulakis
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Molecular insights into the AT1 antagonism based on biophysical and in silico studies of telmisartan
T. Mavromoustakos
Medicinal Chemistry Research, 2013
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Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor
Maria Zervou
Current Medicinal Chemistry, 2015
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Synthesis and biological evaluation of novel antihypertensive compounds
lys mendes
Chem, 2016
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Novel Cyclic Analogs of Angiotensin II with Cyclization between Positions 5 and 7: Conformational and Biological Implications
Garland Marshall
Journal of Medicinal Chemistry, 1996
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