Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors (original) (raw)
Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes
Tomasz Glinka
Bioorganic & Medicinal Chemistry Letters, 1994
View PDFchevron_right
Superimposition of potent non-peptide AT1 receptor antagonists with angiotensin II
John Matsoukas
Letters in Peptide Science, 1996
View PDFchevron_right
N- and C-terminal structure–activity study of angiotensin II on the angiotensin AT2 receptor
Lenka Rihakova
European Journal of Pharmacology, 1998
View PDFchevron_right
Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor
Maria Zervou
Current Medicinal Chemistry, 2015
View PDFchevron_right
The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists
Tomasz Glinka
Bioorganic & Medicinal Chemistry Letters, 1996
View PDFchevron_right
A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function
Emma Jones, Daniel Clayton
Hypertension, 2011
View PDFchevron_right
Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of π*–π* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists
John Matsoukas
Bioorganic & Medicinal Chemistry, 2001
View PDFchevron_right
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
Pierre Lavigne
Biochemical Pharmacology, 2018
View PDFchevron_right
Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential
Thomas Unger
Journal of the Renin-Angiotensin-Aldosterone System, 2009
View PDFchevron_right
Structural basis for selectivity and diversity in angiotensin II receptors
Nilkanth Patel
Nature, 2017
View PDFchevron_right
Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships
Fred Nyberg, Nicole Gallo-payet, Ulrika Rosenström, Mathias Hallberg
Bioorganic & Medicinal Chemistry, 2008
View PDFchevron_right
Design, synthesis, and antihypertensive evaluation of 2′-tetrazolyl and 2′-carboxy-biphenylylmethyl-pyrrolidine scaffolds substituted at their N1, C3, and C4 positions as potential angiotensin II AT1 receptor antagonists
Nasser Ismail
Medicinal Chemistry Research, 2014
View PDFchevron_right
Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT 2 Receptor Affinity
Adolf Gogoll, Mats Larhed, Gunnar Lindeberg, Fred Nyberg
Journal of Medicinal Chemistry, 2005
View PDFchevron_right
Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
Daniel Clayton
Frontiers in Pharmacology, 2015
View PDFchevron_right
Molecular Mechanism Underlying Inverse Agonist of Angiotensin II Type 1 Receptor
Yoshinari Uehara
Journal of Biological Chemistry, 2006
View PDFchevron_right
Structural Insight on the Activity of Type 1 Angiotensin II Peptide Antagonists Using MD Simulations
Hernâni Maia
The Journal of Physical Chemistry B, 2008
View PDFchevron_right
Nanotechnology and Membrane Receptors: Focus on Angiotensin II Receptors
Guang Li
Medical Clinics of North America, 2007
View PDFchevron_right
Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor
Nilkanth Patel
The Journal of biological chemistry, 2015
View PDFchevron_right
Design, Synthesis, Structural Studies, Biological Evaluation, and Computational Simulations of Novel Potent AT 1 Angiotensin II Receptor Antagonists Based on the 4-Phenylquinoline Structure
Maurizio Anzini
Journal of Medicinal Chemistry, 2004
View PDFchevron_right
Update on Angiotensin II Subtype 2 Receptor: Focus on Peptide and Nonpeptide Agonists
Ali Aghazadeh-Habashi
Molecular Pharmacology, 2021
View PDFchevron_right
Emerging Concepts of Regulation of Angiotensin II Receptors
Eugene Patkin
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
View PDFchevron_right
The Second Transmembrane Domain of the Human Type 1 Angiotensin II Receptor Participates in the Formation of the Ligand Binding Pocket and Undergoes Integral Pivoting Movement during the Process of Receptor Activation
Richard Leduc, Pierre Lavigne
Journal of Biological Chemistry, 2009
View PDFchevron_right
Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy
Panagiotis Zoumpoulakis
Journal of Pharmaceutical and Biomedical Analysis, 2003
View PDFchevron_right
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3, 5 side-chain bridges: role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists
Panagiotis Zoumpoulakis
View PDFchevron_right
Nonpeptidic angiotensin II AT1 receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles
Fan Fei
European Journal of Medicinal Chemistry, 2013
View PDFchevron_right
Receptor interactions of the position 4 side chains of angiotensin II analogues: Importance of aromatic ring quadrupole
John Matsoukas
Journal of Molecular Recognition, 1994
View PDFchevron_right
In vitro pharmacological characterization of a new selective angiotensin AT1 receptor antagonist, UR-7280
Julian Garcia
European Journal of Pharmacology, 1996
View PDFchevron_right
The Angiotensin II AT1 Receptor Structure-Activity Correlations in the Light of Rhodopsin Structure
Clovis Nakaie
Physiological Reviews, 2007
View PDFchevron_right
An update on non-peptide angiotensin receptor antagonists and related RAAS modulators
Mrs. Rupinder Sodhi
Life Sciences, 2007
View PDFchevron_right
Distinctions between non-peptide angiotensin II AT1-receptor antagonists
Frederik Fierens
Journal of the Renin-Angiotensin-Aldosterone System, 2001
View PDFchevron_right
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists—A perspective
Prashant Naik, Mange Ram Yadav
Bioorganic & Medicinal Chemistry, 2010
View PDFchevron_right
Design and synthesis of novel antihypertensive drugs
P. Moutevelis-minakakis
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
The design and synthesis of a potent angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone angiotensin II
John Matsoukas
Bioorganic & Medicinal Chemistry, 2000
View PDFchevron_right