Clinical Implications of the 2004 WHO Histological Classification on Non-Invasive Tumours of the Urinary Bladder (original) (raw)
Related papers
Histopathological Gamut of Urinary Bladder Tumors: An Institutional Study
Introduction: The present study was taken up to assess the incidence of different histological variants of bladder tumors, site, age and sex distribution, presenting symptoms and a brief comparison was done about the histopathological features of the tumors occurring in young and old individuals. Material and methods: The present study is a retrospective two year descriptive study conducted in the Department of Pathology, tertiary care hospital in Guntur. The biological materials included in the study were Trans-urethral resection of bladder tumor (TURBT) specimens, complete and partial cystectomies. The formalin fixed specimens were routinely processed and haematoxylin and eosin stained slides were retrieved from the departmental archives and reviewed. Results: The most common location for bladder tumors in the present study was lateral wall constituting 40.9% of the cases followed by posterior wall (20.4%), trigone (13.6%), neck (11.3%), anterior wall (9.1%) and ureteric orifice (4.5%). Conclusion: To conclude, urothelial carcinomas are rare and prognostically better in the age group below 40 years, as most present with non invasive low grade papillary urothelial carcinomas.
News in the classification of WHO 2022 bladder tumors
Pathologica, 2023
The fifth-edition of World Health Organization (WHO) Classification of Tumors series for urinary and male genital tract tumors has been published, six years later the fourth-edition. In these years, new treatment approaches have been implemented and new molecular data on urological cancers are known. Morphology remains the groundwork for taxonomy of the urinary tract tumors. However, a molecular approach to classification of urothelial carcinomas and the management of selected neoplasms with new therapeutic modalities such as immunotherapy are emerging. More data are needed for the application of these advances in routine pathology practice and patient management. The 2022 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs represents an update in classification on urinary tract tumors. It also offers new insights with regards to the grading of heterogeneous non-invasive urothelial neoplasms, the definition of inverted neoplasms, the grading of invasive urothelial carcinomas, the diversity of morphological appearance of urothelial carcinomas, the definition of precursor lesions and the lineage of differentiation of the tumors.
https://www.ijrrjournal.com/IJRR\_Vol.9\_Issue.7\_July2022/IJRR-Abstract02.html, 2022
Introduction: This study was conducted to describe the Histopathological spectrum of various urinary bladder tumors and to classify them according to W.H.O(2004)/ISUP classification of urinary bladder tumors. Methods: This was a cross-sectional, observational study carried out between June 1, 2019 to May 31, 2020 for a period of one year in the Department of Pathology and Urology, Indira Gandhi Medical College, Shimla. One hundred and ninety seven patients (TURBT and radical cystectomy) with primary epithelial urinary bladder cancer were included in the study. However, Patients with inflammatory and metastatic lesions of urinary bladder and post chemoradiotherapy were excluded from the study. Results: The age of patients ranged from 36 to 89 years with mean age of 62 years. Male preponderance was observed with male to female ratio of 6.9:1. Most common histological type found in our study was urothelial carcinoma (98%) followed by other types such as Squamous cell carcinoma (1%), Small cell carcinoma (0.5%) and Adenocarcinoma (0.5%). In urothelial tumors (193), majority, 126(65.3%) cases, were high grade urothelial carcinoma followed by 67(34.7%) cases of low grade urothelial carcinoma. Conclusion: High grade urothelial carcinomas were mostly associated with muscularis propria invasion.
A histological analysis of urinary bladder specimens with elaboration of various neoplastic lesions
IP innovative publication pvt. ltd, 2019
Introduction: Lesions of urinary bladder constitute an important source of clinical signs and symptoms. Both neoplastic and non-neoplastic lesions do occur commonly, however the former being the most common type. Majority of urinary tract tumors are epithelial in origin, among which 90% of them are urothelial in origin. Objective: To evaluate the histopathological spectrum of urinary bladder lesions with emphasis on the neoplastic lesions with reference to 2016 WHO classification of tumors of urinary system. Materials and Methods: This was a prospective study and includes all the urinary bladder specimens received. They were examined grossly and processed completely as per the standard procedure. Multiple sections of 3-5microns were taken and stained with H&E, followed by light microscopic examination to study various non-neoplastic and neoplastic lesions. Results: Total 65 cases were studied, 30 were cystoscopic biopsies and 35 were TURBT specimens. There were 40 males and 25 females constituting up to 61.54 % and 38.46 % respectively. Chronic non-specific cystitis was the common non-neoplastic lesion. Among neoplastic lesion, Invasive urothelial carcinoma was the predominant lesion constituting 22 cases (62.86%). These neoplastic lesions were more common among males (74.28%) with M:F ratio of 2.8:1. Conclusion: Urinary bladder lesions are most frequently encountered by surgical pathologists and are heterogenous. Both benign and malignant lesions are well documented but latter being more common. Many of these are more common in elderly people with male predilection and are often associated with smoking. Identifying the extent of invasion by microscopic examination constitutes an important aspect in urothelial carcinomas.
Histopathological Profile of Bladder Tumors at Aristide Le Dantec University Teaching Hospital
2021
Background: Bladder tumor represents the second most frequent cancer of the urogenital tract after prostate cancer. The frequency of squamous cell carcinoma is higher in Africa due to the bilharzian endemic. In Western countries, urothelial carcinoma accounts for over 90% of bladder tumors. The aim of this study was to report the histological types of bladder tumors while describing the epidemiological profile of the patients.
Spectrum of Lesions in Urinary Bladder- A Histopathological Study
Journal of Universal College of Medical Sciences, 2018
Introduction: The lesions of urinary bladder both non-neoplastic and neoplastic pose a common source of both morbidity and mortality. An accurate diagnosis of these lesions requires cystoscopy which allows a direct visualization of the bladder mucosa and biopsies of suspected lesions. Urinary bladder cancer is sixth most common cancer worldwide and represents a heterogeneous group of neoplasms. The current study aimed to study the different bladder lesions and its clinical features to detect it in early stage and as a mainstay option in the diagnosis and follow up. Materials and methods: This was a retrospective analysis of biopsies of urinary bladder submitted to the department of pathology over a period of 12 months. The study was approved by the institutional review board of the Universal College of Medical Sciences (UCMS-TH). All the urinary bladder biopsies received in the department were included in the study whereas autolysis of specimen and inadequate biopsies were excluded...
Journal of Ayub Medical College, Abbottabad : JAMC
Classification of urothelial bladder tumours is an important factor in the treatment and prognosis of these lesions. Over the years many classifications have been proposed for this purpose. The objective of this study was to classify urothelial neoplasms of the urinary bladder using the latest WHO/ISUP Consensus Classification 1998 and WHO Classification 1972 and compare the two regarding interobserver variability. This study included 100 consecutive biopsy specimens of urothelial neoplasms of the urinary bladder diagnosed at the department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi. These were classified according to WHO Classification 1972 and WHO/ISUP Consensus Classification 1998 by 2 groups of pathologists independently. The tumour categories for WHO classification 1972; papilloma, and transitional cell carcinoma (TCC) grades I, II and III were compared with the WHO/ISUP Consensus Classification entities of papilloma, papillary neoplasm of low malignant ...
Profiles of histopathological lesions of urinary bladder: A five years study
Journal of Pathology of Nepal, 2016
Background: Neoplastic and non-neoplastic urinary bladder lesions are the main reasons for morbidity and mortality throughout the world. Amongst these, urothelial carcinoma is a common primary tumor of urinary bladder (90%). The objective of this study is to determine the profile of various urothelial lesions received in Army Hospital within 5 years of period. Materials and methods: Five years retrospective study of cystoscopic biopsies and radical cystectomy specimens were carried out in Department of Pathology, Army hospital. Results: Out of 53 cystoscopic biopsies and radical cystectomy specimens, 42 were neoplastic and 11 were non neoplastic lesions. Thirty six urothelial carcinomas were observed out of which 20 were high grade urothelial carcinoma and 16 were low grade. Out of 20 high grade urothelial carcinoma, 17 had muscle invasion and 3 had invasion upto lamina propria. Of 16 low grade urothelial carcinoma, 12 were noninvasive, 2 had invasion upto lamina propria and 2 had muscle invasion. Papilloma was the commonest benign lesions found (7.1%) followed by papillary urothelial neoplasms of low malignant potential (PUNLMP) (2.4%) and hemangioma (2.4%). Conclusion: This article have highlighted upon the importance of histopathological study in evaluating urinary bladder lesions. Also, it has helped in determining that neoplastic lesions were more common than non-neoplastic lesions as seen in our study. A great majority of neoplastic lesions were of urothelial origin. Cystoscopic studies and biopsies help in early detection of bladder neoplasms and they form the mainstay of the diagnosis and follow up.
A varied morphological spectrum of urinary bladder carcinoma - A rare diagnostic entity
IP innovative publication pvt. ltd, 2019
Bladder carcinoma is the seventh most common malignancy worldwide and multiple risk factors have been linked to bladder cancer. Urothelial carcinoma accounts for the most common histological subtype and has a propensity for divergent differentiation. The clinical outcome of some of the variants differs from the typical urothelial carcinoma and recognition of these variants is pertinent. Primary small cell carcinoma is an extremely rare malignant neoplasm which accounts for less than 1% of urinary bladder cancer. We present two cases of bladder carcinoma in elderly men with varied histomorphological subtypes which posed a diagnostic challenge.