original ) (raw )Following the trail of lipids: Signals initiated by PI3K function at multiple cellular membranes
Adam Naguib
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Pkh1/2-dependent phosphorylation of Vps27 regulates ESCRT-I recruitment to endosomes
Bruno Rinaldi
Molecular Biology of the Cell, 2012
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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
James Woodgett
The Biochemical journal, 1998
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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
Richard Currie
Biochemical Journal, 1999
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Signalling through phosphoinositide 3-kinases: the lipids take centre stage
Bart Vanhaesebroeck
Current Opinion in Cell Biology, 1999
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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
Ban-hock Toh
Proceedings of the National Academy of Sciences, 1997
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Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo
Bart Vanhaesebroeck
The EMBO Journal, 1999
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Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway
Veronique Calleja
Journal of cell science, 2015
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PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function
Miriam Martini
Developmental Cell, 2014
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Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
Colin Traer
The Journal of Cell Biology, 2005
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Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate
D. Gillooly
Seminars in Cell & Developmental Biology, 2001
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Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes
J. Meyer , William Maltese
Journal of Cell Science, 2006
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Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling
Marketa Zvelebil
The Journal of biological chemistry, 2001
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The role of phosphoinositide 3-kinase C2α in insulin signaling
Gianluca Sala
Journal of Biological …, 2007
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Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Andreas Brech
Nature cell biology, 2017
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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
Bruno Filoche-Rommé , Odile Flamand , Baptiste Ronan
Nature Chemical Biology, 2014
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Signaling by Distinct Classes of Phosphoinositide 3-Kinases
Bart Vanhaesebroeck
Experimental Cell Research, 1999
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Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate Retriever-mediated recycling on endosomes
Ezra Burstein
eLife, 2022
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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
A. Klippel
Molecular and cellular biology, 1996
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Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization
Paul Whitley
Journal of Biological Chemistry, 2003
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Using structure to define the function of phosphoinositide 3-kinase family members
Mike Waterfield
FEBS Letters, 1997
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Essential Role of Class II Phosphatidylinositol-3-kinase-C2α in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells
Kuntal Biswas
Journal of Biological Chemistry, 2012
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Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
Kaoru Takegawa
The Journal of cell biology, 1995
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The type Iα inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
Ivan Ivetac
Molecular Biology of The Cell, 2005
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Phosphatidylserine Binding Is Essential for Plasma Membrane Recruitment and Signaling Function of 3-Phosphoinositide-dependent Kinase-1
Nathan Lucas
Journal of Biological Chemistry, 2011
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Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Controls Trafficking but Not Silencing of Endocytosed Receptors
Andreas Brech
Molecular Biology of the Cell, 2006
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Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase
Srimonti Sarkar
Journal of Cell Science, 2002
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Phosphoinositide 3-kinases: A conserved family of signal transducers
Bart Vanhaesebroeck
Trends in Biochemical Sciences, 1997
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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
Anke Klippel
Molecular and cellular biology, 1997
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Interaction of Pik1p and Sjl proteins in membrane trafficking
Carlos Romero
FEMS Yeast Research, 2005
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Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III protects from dephosphorylation and stabilizes lipid kinase activity
Angelika Hausser , Klaus Pfizenmaier
Journal of Cell Science, 2006
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Role of the Phox Homology Domain and Phosphorylation in Activation of Serum and Glucocorticoid-regulated Kinase-3
James Woodgett
Journal of Biological Chemistry, 2006
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A Complex Interplay of Anionic Phospholipid Binding Regulates 3- Phosphoinositide-Dependent-Kinase-1 Homodimer Activation
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