Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways (original) (raw)
Dominant negative effect of the truncated p110 subunit of phosphatidylinositol-3 kinase
Shigeo Ohno
IUBMB Life, 1996
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Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta
J. Schlessinger
Molecular and Cellular Biology, 1994
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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
Klaus Okkenhaug
Nature, 2006
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Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo
Bart Vanhaesebroeck
The EMBO Journal, 1999
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PKCα reduces the lipid kinase activity of the p110α/p85α PI3K through the phosphorylation of the catalytic subunit
Peter Parker
Biochemical and Biophysical Research Communications, 2006
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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
Anke Klippel
Molecular and cellular biology, 1997
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Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase
Minghao sun
Cell Cycle, 2011
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Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity
James Dickson
PloS one, 2013
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Phosphatidylinositol 3-kinase: a novel effector
Peter Parker
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1992
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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Marketa Zvelebil
Molecular and cellular biology, 2000
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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
James Woodgett
The Biochemical journal, 1998
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Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
J. Schlessinger
Molecular and cellular biology, 1993
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A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
ripudaman singh
Biochemical Journal, 2011
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Tyrosine 508 of the 85-Kilodalton Subunit of Phosphatidylinositol 3-Kinase Is Phosphorylated by the Platelet-Derived Growth Factor Receptor
Anke Klippel
Biochemistry, 1994
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p110delta , a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes
Christi Wood
Journal of Biological Chemistry, 1997
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A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase
hashem dbouk
Proceedings of the …, 2010
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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
James Mcilroy
… and cellular biology, 1998
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PI3King the right partner: unique interactions and signaling by p110ß
hashem dbouk
Postdoc Journal, 2015
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Phosphatidylinositol 3-kinase: the oncoprotein
Sohye Kang
Current topics in microbiology and immunology, 2010
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Regulation of p110δ PI 3-Kinase Gene Expression
Bart Vanhaesebroeck
PLoS ONE, 2009
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Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase
hashem dbouk
PLoS ONE, 2013
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Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines
Tamara Chessa
PLoS ONE, 2013
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Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor
David Moscatello
Journal of Biological Chemistry, 1998
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Binding of a Diphosphotyrosine-containing Peptide That Mimics Activated Platelet-derived Growth Factor Receptor beta Induces Oligomerization of Phosphatidylinositol 3-Kinase
Meredith Layton
Journal of Biological Chemistry, 1998
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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Bart Vanhaesebroeck
Proceedings of the National Academy of Sciences, 2007
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Phosphatidylinositol 3-Kinase-dependent Membrane Recruitment of Rac-1 and p47phox Is Critical for -Platelet-derived Growth Factor Receptor-induced Production of Reactive Oxygen Species
Heinrich Sauer
Journal of Biological Chemistry, 2008
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Activation of phosphatidylinositol 3-kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: assessment of the role of protein kinase B and p70 S6 kinase
Trond Stokke
Biochemical Journal, 2000
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Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
Alexandre Arcaro, Bart Vanhaesebroeck
The EMBO Journal, 2002
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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
Richard Currie
Biochemical Journal, 1999
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The p110 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110
Bart Vanhaesebroeck
Proceedings of the National Academy of Sciences, 2008
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Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking
Dan Longo
Journal of Biological Chemistry, 1995
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Requirement of Phosphatidylinositol-3 Kinase for Activation of JNK/SAPKs by PDGF
MARCO LOPEZ
Biochemical and Biophysical Research Communications, 1997
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Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)
O. Vadas
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