SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells (original) (raw)
A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival
Puneet Singh
BMC Research Notes, 2011
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SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells
Paddy Tighe
Oncotarget, 2016
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Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
Susanne Klein-scory
Proceedings of the National Academy of Sciences, 2000
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Role of Smad4 (DPC4) inactivation in human cancer
登志夫 黒木黒木
Biochemical and Biophysical Research Communications, 2003
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Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
Akira Horii
Oncogene, 2003
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Targeting Endogenous Transforming Growth Factor β Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype 1
Subramanian G
Cancer research, 2004
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Targeting Endogenous Transforming Growth Factor β Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype
Sarvajit Chakravarty
Cancer Research, 2004
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Evidence That Smad2 Is a Tumor Suppressor Implicated in the Control of Cellular Invasion
M. Mareel
Journal of Biological Chemistry, 1999
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Targeting Endogenous Transforming Growth Factor Receptor Signaling in SMAD4Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype1
Glenn McEnroe
2004
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Evidence for a Role of Smad3 and Smad2 in Stabilization of the Tumor-derived Mutant Smad2.Q407R
Céline Prunier
Journal of Biological Chemistry, 2003
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Smad4-expression is decreased in breast cancer tissues: a retrospective study
Jürgen Dippon
BMC cancer, 2006
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Aberrant signaling of TGF-β1 by the mutant Smad4 in gastric cancer cells
Chung-Hee Sonn
Cancer Letters, 2003
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Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells
Geert Berx
Oncogene, 2002
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Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomas
Aziza Nassar
Cancer Biology & Therapy, 2006
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Loss of Canonical Smad4 Signaling Promotes KRAS Driven Malignant Transformation of Human Pancreatic Duct Epithelial Cells and Metastasis
Emin Ibrahimov
PLoS ONE, 2013
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Tumor Suppressor Gene Smad4/DPC4, Its Downstream Target Genes, and Regulation of Cell Cyclea
Jason Fleming
Annals of The New York Academy of Sciences, 1999
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Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway
Nicolas Jonckheere, Isabelle Van Seuningen
The American Journal of Pathology, 2012
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Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells
FRANCISCO JOSE NICOLAS
Biochemical Journal, 2004
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Functional blockade of Smad4 leads to a decrease in -catenin levels and signaling activity in human pancreatic carcinoma cells
diana Romero
Carcinogenesis, 2008
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TGFβ1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation
Andre Menke
Oncogene, 2000
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Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer
Keli Xu
Journal of Cell Biology
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Smad2 and Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions Transmit Malignant TGF-β Signal in Later Stages of Human Colorectal Cancer
Jun-ichi Fujisawa
Cancer Research, 2009
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Expression of Smad proteins in human colorectal cancer
Maréne Landström
International Journal of Cancer, 1999
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TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines
Stephen Fink
Oncogene, 2003
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SCFβ-TrCP1 Controls Smad4 Protein Stability in Pancreatic Cancer Cells
Nirag Jhala, Selwyn Vickers
The American Journal of Pathology, 2005
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Smad6 Suppresses TGF-β-Induced Growth Inhibition in COLO-357 Pancreatic Cancer Cells and Is Overexpressed in Pancreatic Cancer
Dean Falb
Biochemical and Biophysical Research Communications, 1999
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Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon Cancer
Sam Thiagalingam
Cancer Research, 2011
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The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
Dean Falb
Oncogene, 1999
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Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-β
Hideaki Ijichi
Oncogene, 2005
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Transforming growth factor-β-induced growth inhibition in a Smad4 mutant colon adenoma cell line
Sam Thiagalingam
2001
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SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma
Andrew Stubbs
Oncogene, 2014
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Inactivation of Smad4 Accelerates KrasG12D-Mediated Pancreatic Neoplasia
Nirag Jhala, Selwyn Vickers
Cancer Research, 2007
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