Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin (original) (raw)
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein
Edda Fiebiger
The EMBO Journal, 2002
View PDFchevron_right
A membrane protein required for dislocation of misfolded proteins from the ER
Brendan Lilley
Nature, 2004
View PDFchevron_right
Distinct Steps in Dislocation of Luminal Endoplasmic Reticulum-associated Degradation Substrates: ROLES OF ENDOPLASMIC RETICULUM-BOUND p97/Cdc48p AND PROTEASOME
Yechiel Elkabetz
Journal of Biological Chemistry, 2003
View PDFchevron_right
A Proteasomal ATPase Contributes to Dislocation of Endoplasmic Reticulum-associated Degradation (ERAD) Substrates
Shoshana Bar-nun
Journal of Biological Chemistry, 2008
View PDFchevron_right
Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox Potential
Igor Bacik
The Journal of Cell Biology, 1998
View PDFchevron_right
Distinct Steps in Dislocation of Luminal Endoplasmic Reticulum-associated Degradation Substrates
Shoshana Bar-nun
Journal of Biological Chemistry, 2003
View PDFchevron_right
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways
Robert Spooner
PloS one, 2011
View PDFchevron_right
Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation
Jeff Grotzke
Proceedings of the National Academy of Sciences, 2013
View PDFchevron_right
The Role of BiP in Endoplasmic Reticulum-associated Degradation of Major Histocompatibility Complex Class I Heavy Chain Induced by Cytomegalovirus Proteins
Nagendra R Hegde
Journal of Biological Chemistry, 2006
View PDFchevron_right
A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins
Linda Hendershot
Journal of Biological Chemistry, 2013
View PDFchevron_right
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
Linda Hendershot
Faculty reviews, 2022
View PDFchevron_right
Disposing of misfolded ER proteins: A troubled substrate's way out of the ER
Linda Hendershot
Molecular and Cellular Endocrinology, 2019
View PDFchevron_right
Selective Targeting of Proteins within Secretory Pathway for Endoplasmic Reticulum-associated Degradation
Marco Bestagno
Journal of Biological Chemistry, 2012
View PDFchevron_right
Reduction of Interchain Disulfide Bonds Precedes the Dislocation of Ig-µ Chains from the Endoplasmic Reticulum to the Cytosol for Proteasomal Degradation
Roberto Sitia
Journal of Biological Chemistry, 2001
View PDFchevron_right
Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery
Beverley M (Dancy) Rabbitts
Journal of Biological Chemistry, 2008
View PDFchevron_right
Targeted Strategies for Degradation of Key Transmembrane Proteins in Cancer
V. Sakanyan
View PDFchevron_right
Endoplasmic reticulum-associated protein degradation
Lorenzo Frigerio
Seminars in Cell and …, 2000
View PDFchevron_right
NEW EMBO MEMBER'S REVIEW: For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection
Dieter H Wolf
The EMBO Journal, 2003
View PDFchevron_right
The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER
Robert Gemmill
Journal of Experimental Medicine, 2009
View PDFchevron_right
Endoplasmic reticulum-associated protein degradation—one model fits all?
Bassam Ali
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004
View PDFchevron_right
Pivotal Role of Calnexin and Mannose Trimming in Regulating the Endoplasmic Reticulum-associated Degradation of Major Histocompatibility Complex Class I Heavy Chain
Neil Bulleid
Journal of Biological Chemistry, 2000
View PDFchevron_right
Targeted protein degradation mechanisms
Jesse Chen
Drug Discovery Today: Technologies, 2019
View PDFchevron_right
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics
Jeffrey Simard
2021
View PDFchevron_right
Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases
George Spitalny
View PDFchevron_right
The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group
Adrian Wiestner
PLoS ONE, 2010
View PDFchevron_right
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum
Benedict Cross
Journal of Cell Science, 2009
View PDFchevron_right
ER-associated degradation: Protein quality control and beyond
pedro carvalho
Journal of Cell Biology, 2014
View PDFchevron_right
Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein
Benedict Cross
Molecular Membrane Biology, 2009
View PDFchevron_right
Cytosolic aggregates in presence of non‐translocated proteins perturb endoplasmic reticulum structure and dynamics
Subhrangshu Das
Traffic, 2019
View PDFchevron_right
Protein Dislocation from the Endoplasmic Reticulum - Pulling Out the Suspect
Ernst Jarosch, Thomas Sommer
Traffic, 2002
View PDFchevron_right
Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide
Michael Silverman
Journal of Biological Chemistry, 2006
View PDFchevron_right
A cell-based screen for inhibitors of protein folding and degradation
Chan-Eun Nam
Cell Stress and Chaperones, 2010
View PDFchevron_right
Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER
M. Molinari
The Journal of Cell Biology, 2002
View PDFchevron_right
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
Kai-uwe Fröhlich
2002
View PDFchevron_right
Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein
Martin Latterich, Carol Harty
The EMBO Journal, 2004
View PDFchevron_right