Deciphering the Role of the ADAM17-Dependent Secretome in Cell Signaling (original) (raw)

The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth

Abdulbasit Amin

Life Science Alliance

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The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth

Abdulbasit Amin

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ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

Douglas Lauffenburger

Proceedings of the National Academy of Sciences, 2013

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Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets

Gabriel Mazzucchelli

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016

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Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer

Ashish Sharma

Clinical cancer research : an official journal of the American Association for Cancer Research, 2016

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A monoclonal antibody to ADAM17 inhibits tumor growth by inhibiting EGFR and non-EGFR mediated pathways

Melissa Damschroder

Molecular Cancer Therapeutics, 2015

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The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition

Franck Chesnel

PLoS ONE

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Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by Difference Gel Electrophoresis

Joaquín Arribas

Molecular and Cellular Biology, 2006

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Cellular roles of ADAM12 in health and disease

Reidar Albrechtsen

The International Journal of Biochemistry & Cell Biology, 2008

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Post-transcriptional Up-regulation of ADAM17 upon Epidermal Growth Factor Receptor Activation and in Breast Tumors

Joan Bech-serra

Journal of Biological Chemistry, 2007

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ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway

Ying Jiang

Molecular and Cellular Biochemistry, 2012

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An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases

Yuh-pyng Sher

International Journal of Molecular Sciences

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ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression

Niall O'Higgins

Clinical Cancer Research, 2007

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ADAM17 mediates OSCC development in an orthotopic murine model

Lucas Miguel

Molecular cancer, 2014

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The disintegrin domain of ADAM17 antagonises fibroblast-carcinoma cell interactions

Mohammad Shomali

International Journal of Oncology, 2013

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Regulation of ADAM12 Cell-surface Expression by Protein Kinase C ϵ

Peter Parker

Journal of Biological Chemistry, 2004

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ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer

Mark Day

PloS one, 2016

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Identification of ADAM12 as a Novel Basigin Sheddase

Reidar Albrechtsen

International Journal of Molecular Sciences, 2019

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Regulation of ADAM12 Cell-surface Expression by Protein Kinase C

Reidar Albrechtsen

Journal of Biological Chemistry, 2004

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Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

Elisa Nuti

Molecules

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PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways

Peter Parker

PLoS ONE, 2011

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ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin

Joan Bech-serra

Oncogene, 2011

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Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth

Jay Fox

Biomolecules, 2020

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Phosphorylation-dependent Interactions between ADAM15 Cytoplasmic Domain and Src Family Protein-tyrosine Kinases

Jean Harthill

Journal of Biological Chemistry, 2001

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The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

Susana Ovalle

Cellular and Molecular Life Sciences, 2011

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The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Radislav Sedlacek

Cellular and Molecular Life Sciences

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ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling

Mark Day

Cardiovascular Research, 2010

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ADAM-17 expression in breast cancer correlates with variables of tumor …

Michael Duffy

Clinical Cancer …, 2007

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