Overexpression of the signaling adapter FRS2 reconstitutes the cell cycle deficit of a nerve growth factor non-responsive TrkA receptor mutant (original ) (raw )The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor, TrkA
Susan Meakin
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TrkA Tyrosine Residues Involved in NGF-induced Neurite Outgrowth of PC12 Cells
Dan Lindholm
European Journal of Neuroscience, 1995
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A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor-Dependent Cell Survival but Not Neurite Outgrowth
Ela Gryz
Journal of Neurochemistry, 2002
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The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells
Hava Avraham
Journal of Biological Chemistry, 1999
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The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
Shuqian Jing
Cell, 1991
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Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3
Susan Meakin
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
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Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
Garrett Brodeur
Oncogene, 2000
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Neurotrophin-dependent tyrosine phosphorylation of RasGrf1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA
Rachel Buchsbaum
Journal of Biological Chemistry, 2004
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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
David Loeb
Oncogene, 1998
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Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
Bevil Conway
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
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Activity-Dependent Interaction of the Intracellular Domain of Rat TrkA with Intermediate Filament Proteins, the β-6 Proteasomal Subunit, Ras-GRF1, and the p162 Subunit of eIF3
Susan Meakin
Journal of Molecular Neuroscience, 1999
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Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase
Latanya Hammonds-Odie
1996
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Neurotrophin-dependent Tyrosine Phosphorylation of Ras Guanine-releasing Factor 1 and Associated Neurite Outgrowth Is Dependent on the HIKE Domain of TrkA
Susan Meakin
Journal of Biological Chemistry, 2004
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Essential Role of cAMP-response Element-binding Protein Activation by A2A Adenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade
Yijuang Chern
Journal of Biological Chemistry, 2002
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Fibroblast Growth Factor Receptors Participate in the Control of Mitogen-activated Protein Kinase Activity during Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells
Andreas Bikfalvi
Journal of Biological Chemistry, 1999
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GTK, a Src-related Tyrosine Kinase, Induces Nerve Growth Factor-independent Neurite Outgrowth in PC12 Cells through Activation of the Rap1 Pathway
michael welsh
Journal of Biological Chemistry, 2000
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TrkA cross-linking mimics neuronal responses to nerve growth factor
Louis Reichardt , G. Weskamp
1994
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Nerve Growth Factor-Induced Cell Cycle Reentry in Newborn Neurons Is Triggered by p38 MAPK -Dependent E2F4 Phosphorylation
Erika Abanto
Molecular and Cellular Biology, 2012
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NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating
David Gurwitz
Journal of Cellular Biochemistry, 1998
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Neurotrophin-dependent Tyrosine Phosphorylation of Ras Guanine-releasing Factor 1 and Associated Neurite Outgrowh is Dependent on the HIKE domain of TrkA
Susan Meakin
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Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells
Paul M. P. Bergen Henegouwen
Molecular and Cellular Neuroscience, 1996
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Nerve Growth Factor Regulation of Cyclin D1 in PC12 Cells through a p21RASExtracellular Signal-regulated Kinase Pathway Requires Cooperative Interactions between Sp1 and Nuclear Factor-κB
bianca maria zani
Molecular Biology of the Cell, 2008
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TrkA receptor mediates growth cone turning toward a localized source of nerve growth factor
Paul Letourneau
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
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The trkA receptor mediates growth cone turning toward a localized source of nerve growth factor
Paul Letourneau
The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997
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Ras Guanine Nucleotide Releasing Factor 1 (RasGrf1) Enhancement of Trk Receptor-Mediated Neurite Outgrowth Requires Activation of Both H-Ras and Rac
Susan Meakin
Journal of Molecular Neuroscience, 2013
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Nerve Growth Factor Regulation of Cyclin D1 in PC12 Cells through a p21RAS Extracellular Signal-regulated Kinase Pathway Requires Cooperative Interactions between Sp1 and Nuclear Factor- B
Vladimir Popov
Molecular Biology of the Cell, 2008
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Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms
Yung Wong
Cellular Signalling, 2011
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Synchronous Onset of NGF and TrkA Survival Dependence In Developing Dorsal Root Ganglia
Derek Molliver , Fletcher White
Journal of …, 1996
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NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk
David Loeb
Neuron, 1992
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P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation
Katerina Akassoglou
Proceedings of the National Academy of Sciences, 2005
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NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling
Jay Pundavela
Advances in biological regulation, 2014
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Growth Arrest Failure, G1 Restriction Point Override, and S Phase Death of Sensory Precursor Cells in the Absence of Neurotrophin-3
Wael Elshamy
Neuron, 1998
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A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
Armin Blesch
Journal of Neuroscience Research, 2009
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Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities
Stefania Trazzi
Experimental Cell Research, 2007
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NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells
Erik Foehr
The Journal of Neuroscience
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