Non-Syndromic Multiple Keratocystic Odontogenic Tumor: A Rare Case Report and Review of Literature (original) (raw)
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Keratocystic odontogenic tumour -An unusual presentation
IP Innovative Publication Pvt. Ltd., 2017
Keratocystic Odontogenic Tumour (KCOT) is one of the most controversial odontogenic tumor which remains an enigma to the world of dentistry, because of its varied biological behaviour. Initially, it was considered as a cyst but in 2005, WHO reclassified it as keratocystic odontogenic tumor because of its aggressive & recurrent behaviour & placed it in the categories of odontogenic tumors. Histopathologically it has pathognomonic appearance, but in some cases, it may show unusual histopathological presentation & can be confused with other cystic odontogenic tumors. Hard tissue formation in KCOT capsule & presence of Rushton bodies are an uncommon findings. Herewith, we report a case of 26 year old male patient with an unusual histopathologic presentation of KCOT mimicking unicystic ameloblastoma (UAB) at places & also showing Rushton bodies, areas of calcification & darkly stained cells within the capsule.
Diagnostic and treatment features of keratocystic odontogenic tumors
Stomatos, 2013
Keratocystic odontogenic tumors (KCOT) comprise a unique pathological entity characterized by aggressive/destructive behavior and propensity to recurrence. This study describes the diagnostic and treatment features of a KCOT lesion. A 22-year old man was referred for surgical treatment of pericoronitis on tooth no. 37. Panoramic radiography revealed a unilocular, large radiolucent area extending from tooth no. 36 to the left mandibular ramus. Aspiration and incisional biopsy were performed, and the tissue sample was sent for microscopic evaluation. Microscopically, a cystic lesion was observed, lined by keratinized squamous epithelium and fi lled with keratin lamellae, confi rming the diagnosis of KCOT. Surgery was performed in an outpatient setting and involved osteotomy, detachment of the cystic lesion, and removal of teeth no. 36, 37, and 38. The patient was clinically and radiographically followed for 12 months, and no evidence of recurrence was observed. KCOTs should be considered in the differential diagnosis of lesions affecting the posterior region of the mandible. Accurate clinical, radiographic, and microscopic examinations are essential to establish the defi nitive diagnosis and choose the most effective therapy.
Keratocystic Odontogenic Tumour: Current concepts, theory and presentation of 2 contrasting cases
Odontogenic keratocyst (OKC) is a cyst of tooth origin with an aggressive clinical behavior including a high recurrence rate. It has been rechristened to Keratocystic odontogenic tumour (KCOT), as it better reflects its neoplastic nature. We report 2 contrasting cases of KCOT in association with impacted teeth and revisit the various treatment modalities used to tackle the aggressive nature and keep its recurrence at bay. Most promising being use of molecular biology to treat such tumours which could eventually reduce or eliminate the need for aggressive methods to manage the lesions.
AC omparative Study of Sporadic and Multiple Keratocystic Odontogenic Tumor : a Review of 196 Tumors
2008
F rom the files of the Division of Pathology, Department of Diagnosis & Therapeutic Sciences, Meikai Uni- versity School of Dentistry, 196 tumors diagnosed as keratocystic odontogenic tumor (KCOT) based on the guidelines of the 2005 classification of the World Health Organization (WHO) were studied. The features of 152 sporadic KCOTs were compared with those of 44 multiple KCOTs. The age and sex of the patients, the site of occurrence, and the association with nevoid basal cell carcinoma syndrome were taken in consideration. The mean age of patients with multiple KCOTs was lower (22.9 years) than that of patients with sporadic KCOTs (35.6 years). The peak incidence of the tumors was in the third and second decades of life for single and multiple KCOTs respectively. There were no significant histological differ- ences between the two groups except for a greater amount of daughter cysts and a tendency for multiple recurrence in the multiple KCOT group. The term multiple KCOT refers to...
Keratocystic odontogenic tumor: a retrospective study of 183 cases
Journal of Oral Science, 2008
In 2005, the WHO Working Group considered odontogenic keratocyst (OKC) to be a tumor and recommended the term keratocystic odontogenic tumor (KCOT), separating the lesion from the orthokeratinizing variant, which is now considered an odontogenic cyst. We analyzed the clinicopathological features of KCOTs encountered over a period of 28 years at Meikai University Hospital. The diagnosis was confirmed by reevaluation of hematoxylin and eosin-stained slides on the basis of the 2005 WHO Classification. Clinical history was also taken into consideration. A total of 183 KCOTs were found, and the two genders were affected almost evenly (51.3% male; 48.7% female; male to female ratio 1.05 to 1). Patient age at the time of diagnosis ranged from 6 to 78 years, with a peak in the third decade of life (mean age: 32.8 years). The mandible was the site of occurrence of 70.5% of tumors; 16.4% occurred in the maxilla and 13.1% in both. Association with the nevoid basal cell carcinoma syndrome (NBCCS) was found in 6.0% of all tumors, and recurrence was found in 13.1% of patients. We found that tumors that initially appeared in the maxilla alone had a higher recurrence rate than those that first appeared in the mandible alone. Pathological examination of KCOT is important to avoid misdiagnosis and provide appropriate treatment and follow-up.
Odontogenic Keratocyst Tumor: A Case Report and Literature Review
Open Journal of Stomatology, 2016
First described by Philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate. It is now designated by the World Health Organization as a keratocystic odontogenic tumour (KOT). Clinically, the KOT is manifested by an asymptomatic growth. Radiographically, it appears as a well-defined unilocular or multilocular osteolytic lesion. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report a case of keratocystic odontogenic tumor of the upper jaw and review the various diagnoses, therapeutics and follow up aspects of this type of tumors.
Keratocystic odontogenic tumor. Case report and review of the literature
The New York state dental journal, 2013
Keratocystic odontogenic tumor is an intraosseous benign tumor of epithelial origin that can appear as a unicystic or multicystic lesion. It is characterized most significantly by its high recurrence rate. This is why surgical removal is the chosen therapeutic approach in most cases. However, while surgery may be the safest technique to prevent recidivism, it may also result in numerous complications with large tumors. A number of authors have suggested a more conservative treatment for large keratocystic odontogenic tumors. The case examined in this article is that of a 48-year-old male patient who presented with a five-month swelling on the left side of his face, located in the mandibular area.
UNIVERSITY JOURNAL OF DENTAL SCIENCES, 2020
The OdontogenicKeratocystic (OKC) is a developmental cyst derived from the remanants (rest) of the dental lamina with a peculiar biological behavior. Many attempts have been made to classify these cysts from 1887 to WHO 2017 head and neck tumors. Initially classified under developmental odontogenic cyst of jaw by WHO in 1971 and 1992, OKC has then been reclassified and renamed as KeratocysticOdontogenic Tumor (KCOT) in the WHO classifications of head and neck tumors in 2005 due to its aggressive behavior, high recurrence rates and specific histopathological feature. But recently WHO 2017 classification of head and neck tumors reclassified KCOT as a cyst. Despite of so many classification and nomenclature, unfortunately the controversy still exists. KCOT has been rarely reported to transform into a more aggressive lesion like ameloblastoma. We here present a case report of KCOT involving the body and ramus of the mandible having histopathological features suggestive of ameloblastoma...