Interaction of three second-generation anthracyclines with polynucleotides, RNA, DNA, and nucleosomes (original) (raw)

Chuang RY, Chuang LF, Kawahata RT, Israel MEffect of N-trifluoroacetyladriamycin-14-valerate on [3H]thymidine uptake and DNA synthesis of human lymphoma cells. J Biol Chem 258:1062-1065

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Comparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro

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Krishan A, Dutt K, Israel M, Ganapathi RComparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro. Cancer Res 41:2745-2750

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Protein-associated DNA breaks and DNA-protein cross-links caused by DNA nonbinding derivatives of Adriamycin in L1210 cells. Cancer Res

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Krishan A, Israel M, Modest EJ, Frei E IIIDifferences in cellular uptake and cytofluorescence of adriamycin and N-trifluoroacetyladriamycin-14-valerate. Cancer Res 36:2108-2109

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Intercalation with DNA is a prerequisite for Daunomycin, Adriamycin and its congeners in inhibiting DNAase I

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Preclinical Evaluation of Adriamycin-DNA Adducts

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Effects of new N-alkyl analogues of adriamycin on in vitro survival and cell cycle progression of L1210 cells

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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

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Interactions of antitumor drug daunomycin with DNA in solution and at the surface

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Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells

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Equilibrium binding of daunomycin and adriamycin to calf thymus DNA

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Biochemical Pharmacology, 1988

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Comparison of dna scission and cytotoxicity produced by adriamycin and 5-iminodaunorubicin in human colon carcinoma cells

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Binding of saframycin A, a heterocyclic quinone anti-tumor antibiotic to DNA as revealed by the use of the antibiotic labeled with [ 14C]tyrosine or [ 14C]cyanide

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Mechanism of action of the anthracycline anti-tumor antibiotics, doxorubicin, daunomycin and rubidazone: Preferential inhibition of DNA polymerase .ALPHA

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Fluorospectrometric studies on neothramycin and its reaction with DNA

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The interaction of Fe(III), adriamycin and daunomycin with nucleotides and DNA and their effects on cell growth of fibroblasts (NIH-3T3)

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Two mechanisms of adriamycin-DNA interaction in L1210 cells

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Inhibition of RNA Synthesis by Anthracycline Analogs

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Effect of Adriamycin and analogs on the nuclear fluorescence of propidium iodide-stained cells

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Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

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Biochimica et biophysica acta, 1978

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Israel M, Modest EJ, Frei E IIIN-trifluoroacetyladriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin. Cancer Res 35:1365-1368

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N-Trifluoroacetyladriamycin-14-valerate, an Analog with Greater Experimental Antitumor Activity and Less Toxicity than Adriamycin

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Cancer Research, 1975

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Adriamycin analogs. Preparation and biological evaluation of some thio ester analogues of adriamycin and N-(trifluoroacetyl)adriamycin 14-valerate

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Journal of Medicinal Chemistry, 1986

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Short-Term Effects of Four Antibiotics on DNA Synthesis in Endothelial CellsNote

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Pharmacology & Toxicology, 2008

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Interstrand cross-linking by Adriamycin in nuclear and mitochondrial DNA of MCF-7 cells

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Relationship of Adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L1210 cells

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Inhibition of the initiation of leukemic transcription by N-trifluoroacetyladriamycin-14-O-hemiadipate in vitro. Impaired formation of RNA polymerase-DNA complex

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New findings in the study on the intercalation of bisdaunorubicin and its monomeric analogues with naked and nucleus DNA

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Comparison of intracellular drug retention, DNA damage and cytotoxicity of derivatives of doxorubicin and daunorubicin in a human colon adenocarcinoma cell line (LoVo)

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Detection of adriamycin-DNA adducts by accelerator mass spectrometry

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Interaction of adriamycin with DNA as studied by resonance Raman spectroscopy

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In vivo dose—response relationship in bone-marrow cells of mice treated with adriamycin

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Binding of Norfloxacin, Enoxacin and Enrofloxacin to Calf Thymus Dna

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