Antibacterial Activity of Mononuclear Schiff Base Metal Complexes derived from O-Phenylenediamine Derivatives: Synthesis and Spectral Characterization (original) (raw)
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Metal complexes of Mn(II), Fe(II), Co(II) and Cd(II) ions with Schiff base ligand 4-{(pyridin-2-ylimino)methyl}phenol derived from condensation of 2-amino pyridine with 4hydroxybenzaldehyde was prepared. The ligand and complexes were isolated from the reaction in the solid form and characterized by conductivity, magnetic moment, TLC, IR, UV-Visible, thermal analysis and some physical measurements. During complexation reaction with transition metal ions Schiff base act as a deprotonated tridentate ligand and IR spectra showed that N and O atoms are coordinated to the central metal atom. The observed values confirmed that the complexes have octahedral geometry. The Schiff base and its metal complexes have been found to have moderate to strong antibacterial activity.
The Pharma Innovation Journal, 2016
The new bidentate Schiff base ligand namely [(E)-N 1-(4-methoxy benzylidene) benzene-1, 2-diamine] was prepared from condensation of 4-Methoxy benzaldehyde with O-Phenylene diamine at 1:1 molar ratio in ethanol as a solvent in presence of drops of 48% HBr. The structure of ligand (L) was characterized by, FT-IR, U.V-Vis., 1 H-, 13 C-NMR spectrophotometer, melting point and elemental microanalysis C.H.N. Metal complexes of the ligand (L) in general molecular formula [M(L)3], where M= Mn(II), Co(II), Ni(II),Cu(II) and Hg(II); L=(C14H14N2O) in ratio (1:3)(Metal:Ligand) were synthesized and characterized by Atomic absorption, FT-IR, U.V-Vis. spectra, molar conductivity, chloride content, melting point and magnetic susceptibility from the above data the geometrical formula was octahedral for all complexes. And in vitro tests for antibacterial activity showed that most of the prepared compounds display activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeruginosa).
SYNTHESIS, SPECTROSCOPIC STUDIES AND ANTIBACTERIAL ACTIVITY OF NOVEL SCHIFF BASE METAL COMPLEXES
Mononuclear Copper(II), Nickel(II) and Oxovanadium(IV) complexes of new tetradendate Schiff base ligand derived from the condensation of 5-Bromosalicylaldehyde, 4,5, dichloro o-phenylenediamine with pentane-2,4-dione have been synthesized and characterized by analytical, spectral and electrochemical methods. The complexes were found to have the general formula [M(L)]X (where M = (Cu(II), Ni(II), and VO(IV) X=ClO4-, (SO4) 2-L = mononucleating tetradendate ligand). The invitro antimicrobial activities of the synthesized compounds have been tested against the gram negative and gram positive bacteria. A comparative study of minimum inhibitory concentration (MIC) values of the Schiff base and its complexes indicate that the metal complexes exhibit higher antibacterial activity than the free ligand. © 2017, IRJET | Impact Factor value: 6.171 | ISO 9001:2008 Certified Journal | Page 1521
Cu (II) and Ni (II) Complexes of Schiff Base: Synthesis, Characterization and Antibacterial Activity
International Journal of Advanced Research in Chemical Science, 2020
Cu (II) and Ni (II) metal ions complexes of Schiff base derived from the condensation reaction of appropriate amount of ethane-1,2-diamine, Salicylaldehyde and 2-furfuraldehyde in alcoholic medium. The obtained complexes are characterized by using FTIR spectroscopy, UV-Vis spectroscopy, and Magnetic susceptibility and Conductivity measurements. From the above characterizations, all the synthesized complexes obtained as monomeric structure and the metals center moieties are four-coordinated with square planar geometry. The antibacterial screening activity revealed that Cu(II) complexes showed moderate activity against tested bacterial strains and slightly higher compared to the uncoordinated ligand
American Journal of Applied Chemistry, 2018
A Schiff base (SB) is derived from salicylaldehyde and 2-aminopyridine. The transition metal complexes of N i(II), Cu (II), Co and Cd (II) metal ions were prepared with this Schiff base (SB), which were used as ligand. Several physical tools, in particular; elemental analysis, molar conductivity, magnetic susceptibility, infrared spectroscopy (IR), electronic absorption spectroscopy (ESR) to investigate the chemical structure of the prepared transition metal complexes. The elemental analysis data shows the formation of 1:2 [M:2L] complex of the formula of M 2+ L 2 , where M 2+ =Ni(II), Cu(II), Co(II), Cd(II) and L = Schiff base (SB). The molar conductance (conductivity) measurements were revealed that all the complexes are nonelectrolyte in nature. The infrared (IR) spectral studies indicated the binding sites of the Schiff base ligand with the transition metal ions. The magnetic susceptibility measurements and electronic spectral results supported the predicted coordination geometry of the complexes and magnetic properties (para or dia-magnetic nature) of the complexes. The Ni(II), Cu(II), Co(II) ion forms high spin tetrahedral geometry, whereas Cd(II) ion forms low spin tetrahedral structure. The free Schiff base and its complexes have been tested for their antimicrobial activities against four human pathogenic (two gram-positive and two gramnegative) bacteria. The obtained results showed that only Cu(II) complex exhibited strong activity toward human pathogenic gram positive and gram negative bacteria whereas the Ni(II), Co(II) and Cd(II) complexes showed week to moderate antimicrobial activity compared with standard Kanamycin and Ampicillin.
Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes with biacetyl-derived Schiff bases
Journal of The Serbian Chemical Society, 2010
The condensation reactions of biacetyl with orthohydroxyaniline and 2-aminobenzoic acid to form bidendate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML 2 .2H 2 O] where M = Co(II), Ni(II), Cu(II) and Zn(II) and L = HL 1 and HL 2 . These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, and IR, 1 H-NMR and electronic spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141-160 °C. These compounds were also screened for their in-vitro antibacterial activity against four bacterial species, namely; Escherichia coli, Staphylococcus aureus, Salmonella typhi and Bacillus subtillis. The metal complexes were found to have greater antibacterial activity than the uncomplexed Schiff base ligands.
Journal of the Serbian Chemical Society, 2019
A Schiff base ligand L was synthesized by condensation of 1,2-diaminoethane with creatinine. The reaction of the ligand with metal chloride salt gives Co(II) and Cu(II) complexes. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, NMR, UV?Vis, conductivity and magnetic susceptibility measurements as well as thermal analyses. Based on spectral data, tetrahedral geometries have been proposed for the Co(II) and Cu(II) complexes. The molar conductivity data show that the complexes are non-electrolytic in nature. In DFT studies, the geometry of the Schiff base ligand and its Co(II) and Cu(II) complexes were fully optimized using the B3LYP functional together with 6-31g(d,p) and LANL2DZ basis sets. The ligand and its metal complexes were tested against four bacterial species and two fungal species. The results revealed that the metal complexes are more potent against the microbes than the parent ligand.
International Journal of Pharma Research and Health Sciences, 2014
The Metal complexes of Co (II), Ni (II), Cu (II) and Hg (II) with a new Schiffbase derived from 2-Acetyl 5-chloro thiophene and o-Phenylenediamine in methanol are reported. The complexes have been characterized using chemical analysis, (IR, UV-VIS, H1-NMR), conductometric and magnetic data. According to these data, we propose an octahedral geometry for metal (II) complexes. The invitro antibacterial activities of the investigated complexes were evaluated against few microorganisms by well diffusion technique. It was found that the metal complexes have higher activity that the standard drugs. Antibacterial activity of the ligand and its complexes were studied against to gram positive acteria; Staphylococcus aureus and Bacillus subtilis and gram negative bacteria Salmonellatyphi and E. coli.
FUDMA JOURNAL OF SCIENCES
Schiff base of 4-methyl-o-phenylenediamine and 2-hyroxy-1-napthaldehyde was synthesized and was used to prepare some metal (II) complex by refluxing with Metal (II) chloride ions. The ligand and its complexes were characterized by melting point and decomposition temperature, FTIR, solubility, magnetic susceptibility, conductivity measurement and elemental analysis. The IR spectral data revealed that, the Schiff base coordinated to the respective metal(II) ion through the azomethine nitrogen and phenolic oxygen due to the shifting of the azomethine band υ(C = N) from 591cm–1 to 1603 and 1581cm-1 in the spectra of the complexes. The band at 567 and 563cm-1 were due to υ(M–N), and 729-752cm–1 due to υ(M–O) and the infrared spectra of the metal(II) complexes showed strong bands 3443 and 3363cm–1 suggesting the presence of coordinated water in the metal complexes. Molar conductance values determined 9.17 and 10.04W–1cm2mol–1 showed that, the complexes were non-electrolytes. The ligand ...