Proliposome Powders Prepared Using A Slurry Method For The Generation of Beclometasone Dipropionate Liposomes (original) (raw)
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Proliposomes: A novel approach to carrier drug delivery system
Journal of chemical and pharmaceutical research, 2016
Liposomes are employed broadly on all the novel drug delivery in current years. Liposomal suspensions were developed and they resulted in limited shelf life and poor stability problems on long term storage, these problems are overcome by Proliposomes. Proliposomes were discovered by Payne et al in 1986. Proliposomes are free flowing granular product composed of drug and phospholipid precursors which on hydration lead to liposomes .This paper reviews different aspects related to liposomes, proliposomes their method of preparation, comparison between liposomes and proliposomes, characterization of proliposomes, applications and major focus is made on Proliposomes employed for different routes of administration.
An Overview: Methods for Preparation and Characterization of Liposomes as Drug Delivery Systems
Liposomes as artificially prepared vesicles have become important tools for improving delivery of a large number of drugs: antimicrobial agents, drugs against cancer, antifungal drugs, peptide hormones, enzymes, vaccines and genetic materials. Due to the differences in preparation methods and lipid compositions, liposomes can be classified according to their lamellarity, size, charge and application. The flexibility of their behavior can be exploited for the drug delivery through various routes of administration irrespective of their solubility properties. Encapsulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of many drugs mainly through alteration in their biodistribution, targeting the drug to particular tissues. The role of liposomes as drug delivery system is to deliver drug in the controlled manner, reducing undesirable side effects improving its in vitro and in vivo activity, as well as reducing the toxicity of the drug and enhancing the efficacy of the encapsulated drug. This article provides an overview of methods for preparation of liposomes, as well as analytical methods for control physical, chemical and biological parameters for different types of drugs.
PREPARATION OF DRUG LOADED LIPOSOME
A new physicochemical method for preparing homogeneous liposomcs with high trapping efficiency has been developed. In these paper aim was to control the size and study the homogenous paticles activity with high efficacy which can be applied to the medical field. The ratio of phosphatidyl chloline,cholesterol and span 80 is important for the preparation of fine liposome. The role of each of the component was specific for the preparation. The size of liposome was controlled by sonication and vacuum filtration. Streptomycin antibiotic was loaded in the liposome. Extrusion, a well known method of preparation was used.
Open Journal of Pharmacology and Pharmacotherapeutics, 2018
Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were fi rst described in the mid-60s. Nowadays, they are a very useful reproduction, reagent, and device in various scientifi c disciplines, including medicine, chemistry, biochemistry, colloid science, biology, physics, biophysics, mathematics and theoretical. After the initial discoveries liposomes have made their way to the market. Among numerous brilliant new drug delivery systems developed, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to 'second-generation liposomes', in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modifi ed surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper mini review summarizes exclusively Nano-lipids, its applications in medicine scalable techniques in treating dreadful diseases cancer, AIDS, paralysis etcand focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.
International journal of pharmaceutics, 2005
The purpose of this study was to systematically investigate the effect of lipid chain length and number of lipid chains present on lipopeptides on their ability to be incorporated within liposomes. The peptide KAVYNFATM was synthesized and conjugated to lipoamino acids having acyl chain lengths of C8, C12 and C16. The C12 construct was also prepared in the monomeric, dimeric and trimeric form. Liposomes were prepared by two techniques: hydration of dried lipid films (Bangham method) and hydration of freeze-dried monophase systems. Encapsulation of lipopeptide within liposomes prepared by hydration of dried lipid films was incomplete in all cases ranging from an entrapment efficiency of 70% for monomeric lipoamino acids at a 5% (w/w) loading to less than 20% for di- and trimeric forms at loadings of 20% (w/w). The incomplete entrapment of lipopeptides within liposomes appeared to be a result of the different solubilities of the lipopeptide and the phospholipids in the solvent used fo...
Liposomes: Current Approaches for Development and Evaluation
International Journal of Drug Delivery Technology, 2017
Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.
Review Article LIPOSOME AS A POTENTIAL DRUG DELIVERY SYSTEM: A REVIEW
Liposomes are microscopic phospholipid vescicles made of lipid bilayer which are the drug carrier for improving the delivery of therapeutic agents. Research on liposome technology has progressed from conventional vesicles ("first-generation liposomes") to "second-generation liposomes", in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. A significant step in the development of long-circulating liposomes came with inclusion of the synthetic polymer poly-(ethylene glycol) (PEG) in liposome composition. Due to advancement in liposomal technology a number of liposomal formulations are available in market for clinical use, with gene delivery and cancer therapy and some formulations are under clinical trial. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their biodistribution. This review discusses the basic principles of liposome structures and preparations, evaluation parameters of liposomal formulation, pharmacokinetics of liposomes and liposomeencapsulated drugs, the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use, and the problems associated with further exploitation of this drug delivery system.
Role of Liposome in Novel Drug Delivery System
Journal of Drug Delivery and Therapeutics
Liposome was found by Alec Bangham of Babraham Institute in Cambridge, England in 1965.In 1990; drugs with liposome and Amphotericin B were approved by Ireland. In 1995 America F.D.A approved liposor doxodubicin. In 1965s, it was well recognized that microscopic lipid vesicles, known as liposomes, could be utilized to encapsulate drugs and dyes for the purpose of systemic administration and drug targeting.Considerable progress was made in 1980s, in engeneering liposomes to circulate longer in blood and remain intact while doing so. The liposome a microscopic spherical particle formed by a lipid bilayer enclosing an aqueous compartment.An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. Liposome was discovered about 40 years ago by Bangham and coworkersand was defined as microscopic spherical vesicles that form when phospholipids are hydrated or exposed to anaqueous environment. Liposomes are microscopic vesicles composed of a bilayer of phospholipids or any similar amphipathic lipids. They can encapsulate and effectively deliver both hydrophilic and lipophilic substances2-3 and may be used as a non-toxic vehicle for insoluble drugs. Liposomes are composed of small vesicles of phospholipids encapsulating an aqueous space ranging from about 0.03 to 10 µm in diameter. The membrane of liposome is made of phospholipids, which have phosphoric acid sides to form the liposome bilayers. Liposomes can be manufacturing in different lipid comopsitions or by different method show variation in par. Size , size distribution, surface electrical potential, number of lamella, encapsulation efficacy, Surface modification showed great advantage to produce liposomes of different mechanisims, kinetic properties and biodistribution
LIPOSOME AS A POTENTIAL DRUG DELIVERY SYSTEM: A REVIEW
Liposomes are microscopic phospholipid vescicles made of lipid bilayer which are the drug carrier for improving the delivery of therapeutic agents. Research on liposome technology has progressed from conventional vesicles ("first-generation liposomes") to "second-generation liposomes", in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. A significant step in the development of long-circulating liposomes came with inclusion of the synthetic polymer poly-(ethylene glycol) (PEG) in liposome composition. Due to advancement in liposomal technology a number of liposomal formulations are available in market for clinical use, with gene delivery and cancer therapy and some formulations are under clinical trial. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their biodistribution. This review discusses the basic principles of liposome structures and preparations, evaluation parameters of liposomal formulation, pharmacokinetics of liposomes and liposome-encapsulated drugs, the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use, and the problems associated with further exploitation of this drug delivery system.
Application of Various Types of Liposomes in Drug Delivery Systems
Advanced pharmaceutical bulletin, 2017
Liposomes, due to their various forms, require further exploration. These structures can deliver both hydrophilic and hydrophobic drugs for cancer, antibacterial, antifungal, immunomodulation, diagnostics, ophtalmica, vaccines, enzymes and genetic elements. Preparation of liposomes results in different properties for these systems. In addition, based on preparation methods, liposomes types can be unilamellar, multilamellar and giant unilamellar; however, there are many factors and difficulties that affect the development of liposome drug delivery structure. In the present review, we discuss some problems that impact drug delivery by liposomes. In addition, we discuss a new generation of liposomes, which is utilized for decreasing the limitation of the conventional liposomes.