Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation (original) (raw)
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Karena Last
FEBS Letters, 1996
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Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1
André Struglics
Osteoarthritis and Cartilage, 2006
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Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
Corinne Gendron
Arthritis Research Therapy, 2005
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Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay
David Buttle
Molecular Pathology, 1997
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Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis
Pallavi Shukla
Arthritis Research & Therapy, 2014
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Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity
André Struglics
Arthritis research & therapy, 2017
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The Interglobular Domain of Cartilage Aggrecan Is Cleaved by Hemorrhagic Metalloproteinase HT-d (Atrolysin C) at the Matrix Metalloproteinase and Aggrecanase Sites
Jay Fox
Journal of Biological Chemistry, 1998
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Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity
David Buttle
Clinical Molecular …, 1996
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Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties
E. Eugui
Matrix Biology, 2007
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Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis
Jeffrey Weidner
Osteoarthritis and …, 1997
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Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
Karena Last
2000
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Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity
David Buttle
Biochemical and Biophysical Research Communications, 1999
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Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan
Tim Hardingham
The Biochemical journal, 1994
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The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
John Sandy
Arthritis & Rheumatism, 1993
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Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
Peter Roughley
Biochemical Journal, 1999
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Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis
Jennifer Milner
Arthritis & Rheumatism, 2006
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Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis
Ioannis Kanakis
Arthritis & Rheumatology, 2018
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The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
John Mort
Biochemical Journal, 2002
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Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration
Allen Goodship
Osteoarthritis and Cartilage, 2005
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Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan
C. Malemud
Journal of Clinical Investigation, 1976
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Sue Golub
Nature, 2005
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Activation and Inhibition of Endogenous Matrix Metalloproteinases in Articular Cartilage: Effects on Composition and Biophysical Properties
Eliot Frank
Archives of Biochemistry and Biophysics, 1996
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Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?
David Buttle
Molecular Pathology, 1995
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Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
Priya Chockalingam
Arthritis & Rheumatism, 2004
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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain
Karena Last
Biochemical Journal, 1993
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Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation
Rolf Bräuer
Osteoarthritis and Cartilage, 2006
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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Peter Roughley
European cells & materials
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Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice
Roger Mason
Arthritis & Rheumatism, 2001
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Inhibition of Cartilage Degradation and Changes in Physical Properties Induced by IL-1β and Retinoic Acid Using Matrix Metalloproteinase Inhibitors
John Sandy
Archives of Biochemistry and Biophysics, 1997
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Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
Ioannis Kanakis
Scientific Reports
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A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology
David Kooyman
Disease Markers
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Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue
Charles Malemud
Journal of Clinical Investigation, 1976
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Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP
Alberto M Pendas
Febs Letters, 2000
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The role of aggrecan in normal and osteoarthritic cartilage
John Mort
Journal of Experimental Orthopaedics, 2014
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Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
George Dodge
Osteoarthritis and Cartilage, 2003
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