Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1
André Struglics
Osteoarthritis and Cartilage, 2006
View PDFchevron_right
The role of aggrecan in normal and osteoarthritic cartilage
John Mort
Journal of Experimental Orthopaedics, 2014
View PDFchevron_right
Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis
William Fisher
BMC musculoskeletal disorders, 2016
View PDFchevron_right
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
John Mort
Biochemical Journal, 2002
View PDFchevron_right
Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity
David Buttle
Biochemical and Biophysical Research Communications, 1999
View PDFchevron_right
Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis
Ibrahim AL-Shal
Hss Journal, 2010
View PDFchevron_right
A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid
André Struglics
Matrix Biology, 2010
View PDFchevron_right
ELISA for the core protein of the cartilage large aggregating proteoglycan, aggrecan: Comparison with the concentrations of immunogenic keratan sulphate in synovial fluid, serum and urine
Jens-christian Poulsen
Clinica Chimica Acta, 1994
View PDFchevron_right
Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity
André Struglics
Arthritis research & therapy, 2017
View PDFchevron_right
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
George Dodge
Osteoarthritis and Cartilage, 2003
View PDFchevron_right
Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes
G. Verbruggen
Osteoarthritis and Cartilage, 2000
View PDFchevron_right
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Demitrios Vynios
The Biochemical journal, 1996
View PDFchevron_right
Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
Corinne Gendron
Arthritis Research Therapy, 2005
View PDFchevron_right
Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants
Karena Last
2000
View PDFchevron_right
Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes
jean-luc wautier
Arthritis & Rheumatism, 2006
View PDFchevron_right
Measures of Molecular Composition and Structure in Osteoarthritis
Bernard Dardzinski
Radiologic Clinics of North America, 2009
View PDFchevron_right
The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals
Elina Momin
Journal of the American Veterinary Medical Association, 2005
View PDFchevron_right
Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
Priya Chockalingam
Arthritis & Rheumatism, 2004
View PDFchevron_right
Differential histochemical staining of glycosaminoglycans in the matrix of osteoarthritic cartilage
Steen Christensen
Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1980
View PDFchevron_right
Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay
David Buttle
Molecular Pathology, 1997
View PDFchevron_right
Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice
Roger Mason
Arthritis & Rheumatism, 2001
View PDFchevron_right
Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan
Anna Plaas, Peter Roughley, Ronald Midura
Journal of Biological Chemistry, 1997
View PDFchevron_right
The structure, biochemistry, and metabolism of osteoarthritic cartilage: A review of the literature
Lambert de Bont
Journal of Oral and Maxillofacial Surgery, 1995
View PDFchevron_right
Proteoglycans in normal and severely osteoarthritic human cartilage
Nagaswami Vasan
Biochemical Journal, 1980
View PDFchevron_right
Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
Robert Newton
Annals of the New York Academy of Sciences, 1999
View PDFchevron_right
Aggrecan Turnover in Human Articular Cartilage: Use of Aspartic Acid Racemization as a Marker of Molecular Age
Nathali Kaushansky
View PDFchevron_right
Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study
André Struglics
Arthritis Research & Therapy, 2009
View PDFchevron_right
Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
Paul Salo
Cell Death & Disease
View PDFchevron_right
Distribution of hyaluronan in articular cartilage as probed by a biotinylated binding region of aggrecan
Markku Tammi
Histochemistry and Cell Biology, 1996
View PDFchevron_right
Modern molecular analysis of a traditional disease: Progression in osteoarthritis
Linda Sandell
Arthritis & Rheumatism, 2007
View PDFchevron_right
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Karena Last
FEBS Letters, 1996
View PDFchevron_right
Glycosaminoglycan measured from synovial fluid serves as a useful indicator for progression of Osteoarthritis and complements Kellgren–Lawrence Score
soumya Koppikar
BBA Clinical, 2016
View PDFchevron_right
Activation of neutral metalloprotease in human osteoarthritic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan
C. Malemud
Annals of the Rheumatic Diseases, 1988
View PDFchevron_right
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix☆
Gregory Jay
Osteoarthritis and Cartilage, 2003
View PDFchevron_right
Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains
André Struglics
Osteoarthritis and Cartilage, 2011
View PDFchevron_right