Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (original) (raw)
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
Sean Yu
Bioorganic & Medicinal Chemistry, 2006
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Design and structure–activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization
Gregor Mlinsek
Bioorganic & Medicinal Chemistry, 2001
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New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification
alexey romanov
PLoS ONE, 2011
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Structure of a novel thrombin inhibitor with an uncharged d-amino acid as P1 residue
Peter Goettig
European Journal of Medicinal Chemistry, 2008
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Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position
Joseph Vacca
Journal of Medicinal Chemistry, 1997
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In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors
richard soll
Bioorganic & Medicinal Chemistry Letters, 1998
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Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors
Juliane Barbosa
PLOS One, 2012
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Structure–activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor
richard soll
Bioorganic & Medicinal Chemistry Letters, 2000
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Lawrence Berliner
Journal of protein chemistry, 2000
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Novel Potent and Selective Thrombin Inhibitors Based on a Central 1,4-Benzoxazin-3(4 H )-one Scaffold △
Janez Ilaš
Journal of Medicinal Chemistry, 2008
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Design of Weakly Basic Thrombin Inhibitors Incorporating Novel P1 Binding Functions: Molecular and X-ray Crystallographic Studies
Giuseppina Simone
Biochemistry, 2003
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Structure-Based Design of Residue 1 Analogs of the Direct Thrombin Inhibitor Pentapeptide FM 19
Henry I. Mosberg
Chemical Biology & Drug Design, 2010
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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human α-thrombin
james fethiere
Protein Science, 2008
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Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Bruce Damiano
Journal of Medicinal Chemistry, 2010
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P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
Joseph Vacca
Bioorganic & Medicinal Chemistry Letters, 2005
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2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors
Bruce Tomczuk
Bioorganic & Medicinal Chemistry Letters, 2007
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Structure-Based Design and Structure-Activity Relationships of D-Phe-Pro-D-Arg-P1′-CONH2 Tetrapeptides Inhibitors of Thrombin
ziqian wang
Understanding Biology Using Peptides
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Progress in the design of low molecular weight thrombin inhibitors
Dinesh Dikshit
Medicinal Research Reviews, 2005
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Rational design of selective thrombin inhibitors
Sangsoo Kim
Bioorganic & Medicinal Chemistry Letters, 1997
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Technical Scale Synthesis of a New and Highly Potent Thrombin Inhibitor
Bernd Schaefer
Synthesis, 2004
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SSR182289A, a selective and potent orally active thrombin inhibitor
gilbert lassalle
Bioorganic & Medicinal Chemistry, 2004
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Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity
C. Altomare
Journal of Medicinal Chemistry, 2013
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Design and synthesis of potent and selective macrocyclic thrombin inhibitors
Joseph Vacca
Bioorganic & Medicinal Chemistry Letters, 2003
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Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position
Joseph Vacca
Bioorganic & Medicinal Chemistry Letters, 2003
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Thrombin inhibitors identified by computer-assisted multiparameter design
Christian Merkwirth
Proceedings of the …, 2005
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Structure-Based Design, Synthesis and Evaluation of Novel Peptidic Inhibitors of Thrombin-Induced Activation of Platelets Aggregation
Manfred Philipp
2015
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Send Orders for Reprints to reprints@benthamscience.net Pharmacophore Design, Virtual Screening, Molecular Docking and Optimization Approaches to Discover Potent Thrombin Inhibitors
Meganathan Chandrasekaran
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