Characterization of Plasmodium falciparum serine hydroxymethyltransferase—A potential antimalarial target (original) (raw)

Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

Julie Bowman

Molecular and Biochemical Parasitology, 2009

View PDFchevron_right

Kinetic Mechanism and the Rate-Limiting Step of Plasmodium vivax Serine Hydroxymethyltransferase

Yongyuth Yuthavong

Journal of Biological Chemistry, 2015

View PDFchevron_right

Structures ofPlasmodium vivaxserine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Yongyuth Yuthavong

Acta Crystallographica Section D-biological Crystallography, 2014

View PDFchevron_right

Folate metabolism as a source of molecular targets for antimalarials

Yongyuth Yuthavong

Future Microbiology, 2006

View PDFchevron_right

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Yongyuth Yuthavong

Acta Crystallographica Section D Biological Crystallography, 2014

View PDFchevron_right

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

Yongyuth Yuthavong

Acta Crystallographica Section D Biological Crystallography, 2014

View PDFchevron_right

Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues

Pimchai Chaiyen

Febs Journal, 2009

View PDFchevron_right

Exploring the folate pathway in Plasmodium falciparum

John Hyde

Acta Tropica, 2005

View PDFchevron_right

Molecular dynamics of the interaction of Plasmodium falciparum and human serine hydroxymethyltransferase with 5-formyl-6-hydrofolic acid analogues: design of new potential antimalarials

Pedro Pascutti

Journal of the Brazilian Chemical Society, 2006

View PDFchevron_right

Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum

Niroshini Nirmalan

Molecular Microbiology, 2002

View PDFchevron_right

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization

Tirayut Vilaivan

Malaria Journal, 2012

View PDFchevron_right

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity

Yongyuth Yuthavong

Molecular and Biochemical Parasitology, 2003

View PDFchevron_right

The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants

Yongyuth Yuthavong

The Journal of biological chemistry, 1993

View PDFchevron_right

The Serine Hydroxymethyltransferase of Plasmodium lophurae *

Edward Platzer

The Journal of Protozoology, 1976

View PDFchevron_right

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target

Danoo Vitsupakorn

PeerJ

View PDFchevron_right

Potent and Selective Activity of a Combination of Thymidine and 1843U89, a Folate-Based Thymidylate Synthase Inhibitor, against Plasmodium falciparum

John White

Antimicrobial Agents and Chemotherapy, 2000

View PDFchevron_right

The molecular basis of folate salvage in Plasmodium falciparum: Characterization of two folate transporters

Sanjeev Krishna

Journal of Biological …, 2011

View PDFchevron_right

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

Valerie de Crecylagard

Trends in Parasitology, 2008

View PDFchevron_right

Structural Characterization of PfSerine Hydroxymethyltransferase: A Novel Target for Malaria

Rajasekhar Chikati

Journal of …, 2010

View PDFchevron_right

Genetic and metabolic analysis of folate salvage in the human malaria parasite Plasmodium falciparum

paul wang

Molecular and Biochemical Parasitology, 2004

View PDFchevron_right

The antimalarial triazine WR99210 and the prodrug PS-15: Folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug

Edward Kamau

The American journal of tropical medicine and hygiene

View PDFchevron_right

A three-dimensional structure of Plasmodium falciparum serine hydroxymethyltransferase in complex with glycine and 5-formyl-tetrahydrofolate. Homology modeling and molecular dynamics

Pedro Pascutti

Biophysical Chemistry, 2005

View PDFchevron_right

Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile

N. Palacpac

2004

View PDFchevron_right

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Voravuth Somsak

Malaria Journal, 2011

View PDFchevron_right

The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase

Yongyuth Yuthavong

International Journal for Parasitology, 2007

View PDFchevron_right

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene

Yongyuth Yuthavong

Parasitology International, 2012

View PDFchevron_right

Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors

Jirundon Yuvaniyama

Parasitology, 2005

View PDFchevron_right

Vitamin B6-Dependent Enzymes in the Human Malaria ParasitePlasmodium falciparum: A Druggable Target?

Monika Coronado

BioMed Research International, 2014

View PDFchevron_right