Aurapten and Flindersine From Zanthoxylum coco (original) (raw)
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Zanthoxylum coriaceum alkaloids related to bishordeninyl terpenes
Phytochemistry, 1990
Five new alkaloids related to bishordeninyl terpenes, (N,N'-demethylalfileramine, N,N'-demethylculantraramine, N,N-demethylisoalfileramine, N'-demethylalfileramine, N-demethylalfileramine, and one new monomeric alkaloid 4-(2-N-methyltyraminyl)-(Z)-1,2-epoxy-2-methylbut-3-ene were isolated from the methanolic extract of the leaves of Zanthoxylum coriaceum. These are very closely related to alfileramine, previously isolated as the major leaf component.
Alkaloids and Their Pharmacology Effects from Zanthoxylum Genus
Alkaloids [Working Title]
Zanthoxylum genus (Rutaceae) comprises about 212 species distributed in warm temperature and subtropical areas in the worldwide. Zanthoxylum species have been used in traditional for the treatment of tooth decay, snakebites, blood circulation problems, stomach problems, inflammation, rheumatic, and parasitic diseases. The chemical investigations of Zanthoxylum have been studied by many scientists over the world. Several classes of compounds have been isolated from this genus such as alkaloids, coumarins, and monoterpenes. Of these, alkaloids are the main components and play an important role in Zanthoxylum species. Alkaloids have been shown the potential promise about biological activities: cytotoxic, antimalarial, leishmanicidal, anti-inflammatory, analgesic, antiviral, and antibacterial activities. This chapter will focus on the structure elucidation and pharmacological activities of alkaloids from Zanthoxylum species. In addition, the absolute configuration of some alkaloids from Zanthoxylum genus will be also discussed.
Beilstein Journal of Organic Chemistry, 2013
The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids, namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae.
Chemical Constituents and Biological Activities of the Genus Zanthoxylum: A review
The three Tanzanian wild mushroom species Termitomyces letestui, Lactarius edulis and Agaricus sp. aff. arvensis yielded ergosterol, 5,8-peroxyergosterol and ergosta-5,22-dien-3!-ol, and a mixture of ergosterol, ergosta-7,22-dien-3!-ol and ergosta-7-en-3!-ol whose composition was deduced from gas chromatography/mass spectroscopic (GC/MS) analysis of the trimethysilylated mixture. GC/MS analysis of the lipid fraction from T. letestu revealed the presence of linoleic (C18:2), stearic (C18:0), oleic (C18:1), palmitic (C16:0), pentadecanoic (C15:0) and myristic (C14:0) acid. Polar T. letestui and L. edulis fractions yielded ","1,1#$trehalose and mannitol. Some of the crude extracts from the three mushroom species showed mild antimicrobial, mosquito larvicidal and cytotoxic activities. The chemical composition and antimicrobial activities infer that the three mushroom species are potential functional food substrates.
Bishordeninyl terpene alkaloids from Zanthoxylum avicennae
Phytochemistry, 1999
In addition to "−#!culantraramine and "−#!culantraraminol the bishordeninyl terpene alkaloids\ "−#!culantraramine N!oxide\ "−#!culantraraminol N!oxide and avicennamine\ have been isolated from the leaves of Zanthoxylum avicennae[ Their structures have been assigned by MS and especially by NMR investigations[ Þ 0888 Elsevier Science Ltd[ All rights reserved[