Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors (original) (raw)
Discovery of a novel class of AKT pleckstrin homology domain inhibitors
Vijay Gokhale
Molecular Cancer Therapeutics, 2008
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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity
Igor Vivanco
British Journal of Cancer
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Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo
Vered Klinghofer
Neoplasia, 2005
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In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT
Emmanuelle Meuillet
Cancer Research, 2009
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AKT crystal structure and AKT-specific inhibitors
chandra kumar
Oncogene, 2005
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2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles
Kristin Brown, Nestor Concha, Zhihong Lai
Bioorganic & Medicinal Chemistry Letters, 2010
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Design of Selective, ATP-Competitive Inhibitors of Akt
Shaughnessy Robinson, Shefali Kakar
Journal of Medicinal Chemistry, 2010
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Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)
Octavian Olaru
International Journal of Oncology, 2015
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Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
Sachin Mittal
Bioorganic & Medicinal Chemistry Letters, 2009
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Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
George Hartman
Bioorganic & Medicinal Chemistry Letters, 2008
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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Zhihong Lai
Cancer Research, 2008
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Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors
Nestor Concha
Bioorganic & Medicinal Chemistry Letters, 2009
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Akt Inhibitors as Chemosensitizers
Raymond Jones
2000
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Identification of Akt Pathway Inhibitors Using Redistribution Screening on the FLIPR and the IN Cell 3000 Analyzer
Morten Praestegaard
SLAS Discovery, 2005
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Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Oliver Barker
Scientific Reports
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Development of sulfonamide AKT PH domain inhibitors
Eugene Mash, Emmanuelle Meuillet
Bioorganic & Medicinal Chemistry, 2011
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Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor
Mahmoud A Al-Sha'er
Journal of Molecular Graphics & Modelling, 2018
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A comprehensive structure–activity analysis of protein kinase B-alpha (Akt1) inhibitors
Sudhir Kulkarni
Journal of Molecular Graphics & Modelling, 2010
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Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor
Pablo Aviles
Molecular cancer …, 2010
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Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors
Raymond Jones
Bioorganic & Medicinal Chemistry Letters, 2008
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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
Stefan Gross
Bioorganic & Medicinal Chemistry Letters, 2011
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Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Ruth Ruddle
Molecular Cancer Therapeutics, 2010
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The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane
Ernst Schonbrunn
Cell Death and Differentiation, 2010
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In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines
Alicia Hernández-Campos
Journal of Biomolecular Structure & Dynamics, 2017
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Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2
David Robert
Bioorganic & Medicinal Chemistry Letters, 2011
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Recent progress towards clinically relevant ATP-competitive Akt inhibitors
Igor Mochalkin
Bioorganic & Medicinal Chemistry Letters, 2017
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